chemokine binding Gene Set

Dataset GO Molecular Function Annotations 2023
Category structural or functional annotations
Type biological process
Description Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. (Gene Ontology, GO_0019956)
External Link http://amigo.geneontology.org/amigo/term/GO:0019956
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Genes

18 genes performing the chemokine binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR3 atypical chemokine receptor 3
CCR1 chemokine (C-C motif) receptor 1
CCR3 chemokine (C-C motif) receptor 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
FGF2 fibroblast growth factor 2 (basic)
HMGB1 high mobility group box 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
PDPN podoplanin
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
ZFP36 ZFP36 ring finger protein