chenodeoxycholic acid-2402 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the chenodeoxycholic acid-2402 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANK1 ankyrin 1, erythrocytic
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ARRB2 arrestin, beta 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATG10 autophagy related 10
ATP10B ATPase, class V, type 10B
AURKA aurora kinase A
BCAS1 breast carcinoma amplified sequence 1
C1QTNF1 C1q and tumor necrosis factor related protein 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD59 CD59 molecule, complement regulatory protein
CDK3 cyclin-dependent kinase 3
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CIB2 calcium and integrin binding family member 2
CLUAP1 clusterin associated protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DLG2 discs, large homolog 2 (Drosophila)
DSCAM Down syndrome cell adhesion molecule
DSG3 desmoglein 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA3 ephrin-A3
EXOSC1 exosome component 1
F11R F11 receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FBXO22 F-box protein 22
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FRMD1 FERM domain containing 1
GEMIN7 gem (nuclear organelle) associated protein 7
GM2A GM2 ganglioside activator
GPM6B glycoprotein M6B
GRB7 growth factor receptor-bound protein 7
GSTTP1 glutathione S-transferase theta pseudogene 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICA1 islet cell autoantigen 1, 69kDa
ING2 inhibitor of growth family, member 2
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITM2B integral membrane protein 2B
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KHK ketohexokinase (fructokinase)
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
LTBP3 latent transforming growth factor beta binding protein 3
MAPK8 mitogen-activated protein kinase 8
MCPH1 microcephalin 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEBL nebulette
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
OAZ3 ornithine decarboxylase antizyme 3
OBSL1 obscurin-like 1
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PDLIM5 PDZ and LIM domain 5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCL2 phospholipase C-like 2
PLK4 polo-like kinase 4
POLL polymerase (DNA directed), lambda
PON1 paraoxonase 1
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PTPRA protein tyrosine phosphatase, receptor type, A
RANBP3 RAN binding protein 3
RAP1GAP RAP1 GTPase activating protein
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RGS3 regulator of G-protein signaling 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RTCA RNA 3'-terminal phosphate cyclase
RUNX1 runt-related transcription factor 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SNX13 sorting nexin 13
SPAG8 sperm associated antigen 8
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SS18 synovial sarcoma translocation, chromosome 18
SSBP2 single-stranded DNA binding protein 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TEX15 testis expressed 15
TM2D1 TM2 domain containing 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TRBC1 T cell receptor beta constant 1
TROVE2 TROVE domain family, member 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSCD1 WSC domain containing 1
ZNF177 zinc finger protein 177
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACP6 acid phosphatase 6, lysophosphatidic
ANKRD36 ankyrin repeat domain 36
ANKRD40 ankyrin repeat domain 40
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ART1 ADP-ribosyltransferase 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP7B ATPase, Cu++ transporting, beta polypeptide
AXIN1 axin 1
C17ORF70 chromosome 17 open reading frame 70
C1ORF95 chromosome 1 open reading frame 95
C6ORF47 chromosome 6 open reading frame 47
C7ORF43 chromosome 7 open reading frame 43
CAPN5 calpain 5
CASZ1 castor zinc finger 1
CBX4 chromobox homolog 4
CCDC71 coiled-coil domain containing 71
CD70 CD70 molecule
CDR2L cerebellar degeneration-related protein 2-like
CIC capicua transcriptional repressor
CIT citron rho-interacting serine/threonine kinase
CKB creatine kinase, brain
CNPY4 canopy FGF signaling regulator 4
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPTP ceramide-1-phosphate transfer protein
CRYL1 crystallin, lambda 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDN dendrin
DEAF1 DEAF1 transcription factor
DSPP dentin sialophosphoprotein
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELP6 elongator acetyltransferase complex subunit 6
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FAM188A family with sequence similarity 188, member A
FEM1C fem-1 homolog c (C. elegans)
FLCN folliculin
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GLCE glucuronic acid epimerase
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTCD glutathione S-transferase, C-terminal domain containing
HDAC5 histone deacetylase 5
KIF3B kinesin family member 3B
KLF11 Kruppel-like factor 11
KLK15 kallikrein-related peptidase 15
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LINC00597 long intergenic non-protein coding RNA 597
LSP1 lymphocyte-specific protein 1
MOCOS molybdenum cofactor sulfurase
MTA2 metastasis associated 1 family, member 2
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NIPAL2 NIPA-like domain containing 2
NKX3-2 NK3 homeobox 2
NR2C2 nuclear receptor subfamily 2, group C, member 2
NXF2 nuclear RNA export factor 2
PARG poly (ADP-ribose) glycohydrolase
PCDH12 protocadherin 12
PDZD7 PDZ domain containing 7
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PODXL2 podocalyxin-like 2
PRKG2 protein kinase, cGMP-dependent, type II
PYCR1 pyrroline-5-carboxylate reductase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNF122 ring finger protein 122
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPAP2 RNA polymerase II associated protein 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SHARPIN SHANK-associated RH domain interactor
SHPK sedoheptulokinase
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC22A14 solute carrier family 22, member 14
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPATA2L spermatogenesis associated 2-like
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STAG3 stromal antigen 3
TBC1D2 TBC1 domain family, member 2
TBX19 T-box 19
TEC tec protein tyrosine kinase
TNRC6B trinucleotide repeat containing 6B
TRAF2 TNF receptor-associated factor 2
TRAIP TRAF interacting protein
TRIM26 tripartite motif containing 26
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC23 tetratricopeptide repeat domain 23
TUBA4B tubulin, alpha 4b
URM1 ubiquitin related modifier 1
VEGFB vascular endothelial growth factor B
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WASF3 WAS protein family, member 3
WFDC2 WAP four-disulfide core domain 2
ZNF408 zinc finger protein 408
ZNF668 zinc finger protein 668
ZNF701 zinc finger protein 701