chenodeoxycholic acid-7310 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the chenodeoxycholic acid-7310 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFAP1 actin filament associated protein 1
ATXN2L ataxin 2-like
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BFSP1 beaded filament structural protein 1, filensin
BIRC3 baculoviral IAP repeat containing 3
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
CA5B carbonic anhydrase VB, mitochondrial
CA9 carbonic anhydrase IX
CAV2 caveolin 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CLCN7 chloride channel, voltage-sensitive 7
CTNND2 catenin (cadherin-associated protein), delta 2
CUL7 cullin 7
DAZAP2 DAZ associated protein 2
DESI2 desumoylating isopeptidase 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP8 dual specificity phosphatase 8
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPPK1 epiplakin 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GCFC2 GC-rich sequence DNA-binding factor 2
GIF gastric intrinsic factor (vitamin B synthesis)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GSK3A glycogen synthase kinase 3 alpha
GTF2I general transcription factor IIi
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HOMER3 homer scaffolding protein 3
HSF2 heat shock transcription factor 2
IFIH1 interferon induced with helicase C domain 1
IL15 interleukin 15
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIF5C kinesin family member 5C
KMT2A lysine (K)-specific methyltransferase 2A
KRT34 keratin 34, type I
LIFR leukemia inhibitory factor receptor alpha
LIG3 ligase III, DNA, ATP-dependent
LRP3 low density lipoprotein receptor-related protein 3
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MBNL2 muscleblind-like splicing regulator 2
MID1 midline 1
MLF1 myeloid leukemia factor 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRS2 MRS2 magnesium transporter
MTMR11 myotubularin related protein 11
MTRF1L mitochondrial translational release factor 1-like
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP1 NEDD4 binding protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NF2 neurofibromin 2 (merlin)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NINJ1 ninjurin 1
OSBP2 oxysterol binding protein 2
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PECAM1 platelet/endothelial cell adhesion molecule 1
PIAS4 protein inhibitor of activated STAT, 4
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKP3 plakophilin 3
PLCH1 phospholipase C, eta 1
PLXNB3 plexin B3
PPARA peroxisome proliferator-activated receptor alpha
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRSS16 protease, serine, 16 (thymus)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PWAR5 Prader Willi/Angelman region RNA 5
RAD50 RAD50 homolog (S. cerevisiae)
RASA3 RAS p21 protein activator 3
RPS3A ribosomal protein S3A
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCN1B sodium channel, voltage gated, type I beta subunit
SENP6 SUMO1/sentrin specific peptidase 6
SGPL1 sphingosine-1-phosphate lyase 1
SH3BP2 SH3-domain binding protein 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC35F6 solute carrier family 35, member F6
SMC1A structural maintenance of chromosomes 1A
SPATA2L spermatogenesis associated 2-like
SPRED2 sprouty-related, EVH1 domain containing 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYTL2 synaptotagmin-like 2
TAOK2 TAO kinase 2
TESPA1 thymocyte expressed, positive selection associated 1
TM2D1 TM2 domain containing 1
TMEM231 transmembrane protein 231
TPSAB1 tryptase alpha/beta 1
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TTLL7 tubulin tyrosine ligase-like family member 7
WIPF1 WAS/WASL interacting protein family, member 1
ZBTB7A zinc finger and BTB domain containing 7A
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AHDC1 AT hook, DNA binding motif, containing 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALPK1 alpha-kinase 1
APOLD1 apolipoprotein L domain containing 1
AUH AU RNA binding protein/enoyl-CoA hydratase
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C5ORF45 chromosome 5 open reading frame 45
CAPN15 calpain 15
CASZ1 castor zinc finger 1
CCP110 centriolar coiled coil protein 110kDa
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDADC1 cytidine and dCMP deaminase domain containing 1
CLSPN claspin
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CORO2A coronin, actin binding protein, 2A
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DLK1 delta-like 1 homolog (Drosophila)
EAF2 ELL associated factor 2
ELOVL4 ELOVL fatty acid elongase 4
ELP6 elongator acetyltransferase complex subunit 6
EPHA4 EPH receptor A4
ERAP2 endoplasmic reticulum aminopeptidase 2
EXTL3 exostosin-like glycosyltransferase 3
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM173A family with sequence similarity 173, member A
FAM53B family with sequence similarity 53, member B
FANCC Fanconi anemia, complementation group C
FBXL15 F-box and leucine-rich repeat protein 15
FOXC1 forkhead box C1
GMIP GEM interacting protein
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HOOK2 hook microtubule-tethering protein 2
HOXC13 homeobox C13
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IFI6 interferon, alpha-inducible protein 6
IL11RA interleukin 11 receptor, alpha
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KDM5C lysine (K)-specific demethylase 5C
KIAA0319L KIAA0319-like
KIRREL kin of IRRE like (Drosophila)
KLHL25 kelch-like family member 25
KLHL3 kelch-like family member 3
LIN7B lin-7 homolog B (C. elegans)
LNPEP leucyl/cystinyl aminopeptidase
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAGEA6 melanoma antigen family A6
MUC3B mucin 3B, cell surface associated
NBEAL2 neurobeachin-like 2
NCS1 neuronal calcium sensor 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGB5 protocadherin gamma subfamily B, 5
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PLAC1 placenta-specific 1
PLD2 phospholipase D2
PPL periplakin
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RBL1 retinoblastoma-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
SAMD9 sterile alpha motif domain containing 9
SCAMP5 secretory carrier membrane protein 5
SETD8 SET domain containing (lysine methyltransferase) 8
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SOX12 SRY (sex determining region Y)-box 12
SPEG SPEG complex locus
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAR steroidogenic acute regulatory protein
STBD1 starch binding domain 1
TBC1D17 TBC1 domain family, member 17
TBC1D19 TBC1 domain family, member 19
TBXAS1 thromboxane A synthase 1 (platelet)
TENM1 teneurin transmembrane protein 1
TMEM121 transmembrane protein 121
TSKU tsukushi, small leucine rich proteoglycan
TTC17 tetratricopeptide repeat domain 17
TUBA3C tubulin, alpha 3c
TXNL4B thioredoxin-like 4B
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZBTB39 zinc finger and BTB domain containing 39
ZNF197 zinc finger protein 197
ZNF212 zinc finger protein 212
ZNF34 zinc finger protein 34
ZNF580 zinc finger protein 580
ZNF667 zinc finger protein 667
ZNF749 zinc finger protein 749
ZNF778 zinc finger protein 778