| Dataset | GeneRIF Biological Term Annotations |
| Category | structural or functional annotations |
| Type | biological term |
| Description | Heart failure caused by dysfunction of the MYOCARDIUM, leading to defective cardiac emptying (contraction) or filling (relaxation).|Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales.|Heart failure involving the LEFT VENTRICLE.|Heart failure involving the RIGHT VENTRICLE.|A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.|1. inadequacy of the heart so that as a pump it fails to maintain the circulation of blood, with the result that congestion and edema develop in the tissues; SEE ALSO forward heart failure, backward heart failure, right ventricular failure, left ventricular failure. SYN cardiac failure, cardiac insufficiency, congestive heart failure, myocardial insufficiency. 2. resulting clinical syndromes including shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales in various combinations.|Heart failure accompanied by EDEMA, such as swelling of the legs and ankles and congestion in the lungs. (Experimental Factor Ontology, EFO_0000373) |
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47 genes co-occuring with the biological term chf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
| Symbol | Name |
|---|---|
| ACE | angiotensin I converting enzyme |
| ADM | adrenomedullin |
| ADORA2A | adenosine A2a receptor |
| ADRB1 | adrenoceptor beta 1 |
| ADRB2 | adrenoceptor beta 2, surface |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| AGTR1 | angiotensin II receptor, type 1 |
| ALMS1 | Alstrom syndrome protein 1 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 |
| CAPN1 | calpain 1, (mu/I) large subunit |
| CASQ2 | calsequestrin 2 (cardiac muscle) |
| CBR3 | carbonyl reductase 3 |
| CCL2 | chemokine (C-C motif) ligand 2 |
| CCR2 | chemokine (C-C motif) receptor 2 |
| CD40LG | CD40 ligand |
| CNR1 | cannabinoid receptor 1 (brain) |
| CNR2 | cannabinoid receptor 2 (macrophage) |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) |
| CXCL12 | chemokine (C-X-C motif) ligand 12 |
| EDN1 | endothelin 1 |
| FABP3 | fatty acid binding protein 3, muscle and heart |
| GHRL | ghrelin/obestatin prepropeptide |
| GHSR | growth hormone secretagogue receptor |
| GIT2 | G protein-coupled receptor kinase interacting ArfGAP 2 |
| IGFBP1 | insulin-like growth factor binding protein 1 |
| IL33 | interleukin 33 |
| KCNE1 | potassium channel, voltage gated subfamily E regulatory beta subunit 1 |
| KCNQ1 | potassium channel, voltage gated KQT-like subfamily Q, member 1 |
| MIR126 | microRNA 126 |
| MIR130A | microRNA 130a |
| MIR494 | microRNA 494 |
| MIR508 | microRNA 508 |
| MIR665 | microRNA 665 |
| MUC16 | mucin 16, cell surface associated |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein |
| NOS2 | nitric oxide synthase 2, inducible |
| NOS3 | nitric oxide synthase 3 (endothelial cell) |
| NPPA | natriuretic peptide A |
| NPPB | natriuretic peptide B |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 |
| NUP85 | nucleoporin 85kDa |
| POLB | polymerase (DNA directed), beta |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme |
| PRL | prolactin |
| TNF | tumor necrosis factor |
| UTS2 | urotensin 2 |
| VCAM1 | vascular cell adhesion molecule 1 |
