chlorzoxazone Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
Description A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm. (Chemical Entities of Biological Interest Ontology, CHEBI_3655)
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Genes

52 genes differentially expressed following the chlorzoxazone small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
SIRT3 sirtuin 3 5.20265
PAX5 paired box 5 4.51947
TSPAN4 tetraspanin 4 3.91318
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 3.71049
EGR1 early growth response 1 3.53662
ZNF460 zinc finger protein 460 3.46459
EFHC1 EF-hand domain (C-terminal) containing 1 3.3023
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 3.28776
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 3.24644
CD81 CD81 molecule 3.20923
CD19 CD19 molecule 3.08283
VPREB3 pre-B lymphocyte 3 3.06538
SHOX2 short stature homeobox 2 3.00369

decreased expression

Symbol Name Standardized Value
NPEPL1 aminopeptidase-like 1 -5.04851
CSRP1 cysteine and glycine-rich protein 1 -4.83962
ACAT2 acetyl-CoA acetyltransferase 2 -4.56175
UNC13A unc-13 homolog A (C. elegans) -3.96039
CASP10 caspase 10, apoptosis-related cysteine peptidase -3.91881
MAP2K5 mitogen-activated protein kinase kinase 5 -3.87189
GP1BB glycoprotein Ib (platelet), beta polypeptide -3.80262
ZNF646 zinc finger protein 646 -3.71697
SIX5 SIX homeobox 5 -3.68998
ZFHX2 zinc finger homeobox 2 -3.64362
AOC4P amine oxidase, copper containing 4, pseudogene -3.57358
MATK megakaryocyte-associated tyrosine kinase -3.41688
GGTLC2 gamma-glutamyltransferase light chain 2 -3.40279
TRIM17 tripartite motif containing 17 -3.39903
RPAP2 RNA polymerase II associated protein 2 -3.39331
ETV7 ets variant 7 -3.36626
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 -3.35111
KCNQ1DN KCNQ1 downstream neighbor (non-protein coding) -3.31999
PKP1 plakophilin 1 -3.31893
GDF2 growth differentiation factor 2 -3.29887
CTAGE9 CTAGE family, member 9 -3.28608
CNPY4 canopy FGF signaling regulator 4 -3.25984
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -3.17847
NR1I2 nuclear receptor subfamily 1, group I, member 2 -3.17253
PRUNE2 prune homolog 2 (Drosophila) -3.16689
NGF nerve growth factor (beta polypeptide) -3.13532
PCDH1 protocadherin 1 -3.12834
EVX1 even-skipped homeobox 1 -3.12797
ZNF205 zinc finger protein 205 -3.11849
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -3.08549
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -3.08223
FKBP6 FK506 binding protein 6, 36kDa -3.06899
WFDC8 WAP four-disulfide core domain 8 -3.06713
CLCN1 chloride channel, voltage-sensitive 1 -3.06544
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding) -3.0631
RFPL3 ret finger protein-like 3 -3.04849
PICK1 protein interacting with PRKCA 1 -3.04272
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome -3.02659
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -3.01115