cholangiocyte Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The epithelial cell that lines the bile ducts; Biliary epithelial cells or cholangiocytes line a complex tree-like 3-dimensional network of conduits within the liver that form the biliary tract. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003164)
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Genes

240 proteins co-occuring with the tissue cholangiocyte in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
SCTR secretin receptor 2.14641
KRT19 keratin 19, type I 1.97307
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 1.80666
KRT7 keratin 7, type II 1.56427
PRKCSH protein kinase C substrate 80K-H 1.54729
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.51285
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.37819
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 1.35858
GPBAR1 G protein-coupled bile acid receptor 1 1.2922
AQP1 aquaporin 1 (Colton blood group) 1.19534
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 1.16471
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 1.14121
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.1328
SEC63 SEC63 homolog (S. cerevisiae) 1.08943
PCNA proliferating cell nuclear antigen 1.08148
ONECUT1 one cut homeobox 1 1.06603
NR1H4 nuclear receptor subfamily 1, group H, member 4 1.05104
SLC4A2 solute carrier family 4 (anion exchanger), member 2 1.02469
FOXL1 forkhead box L1 1.01243
HNF1B HNF1 homeobox B 1.01025
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.983688
EPCAM epithelial cell adhesion molecule 0.961175
AQP8 aquaporin 8 0.957722
PROM1 prominin 1 0.936629
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.926336
AFP alpha-fetoprotein 0.923339
GCFC2 GC-rich sequence DNA-binding factor 2 0.92291
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.922055
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4 0.892648
GRHL2 grainyhead-like 2 (Drosophila) 0.857574
SLC51B solute carrier family 51, beta subunit 0.854629
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.848745
IL6 interleukin 6 0.816068
S100A4 S100 calcium binding protein A4 0.812309
CLDN7 claudin 7 0.810221
VEGFA vascular endothelial growth factor A 0.794792
WBSCR22 Williams Beuren syndrome chromosome region 22 0.794792
ALB albumin 0.793126
NOTCH2NL notch 2 N-terminal like 0.786468
NOTCH2 notch 2 0.783141
SOX9 SRY (sex determining region Y)-box 9 0.777325
ADCY8 adenylate cyclase 8 (brain) 0.769441
NPS neuropeptide S 0.755777
ADCY6 adenylate cyclase 6 0.744214
NISCH nischarin 0.740915
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.732677
NOTCH1 notch 1 0.726097
MUC1 mucin 1, cell surface associated 0.717472
MIR95 microRNA 95 0.71583
PROX1 prospero homeobox 1 0.71501
FABP6 fatty acid binding protein 6, ileal 0.712139
SLC51A solute carrier family 51, alpha subunit 0.705583
HRH4 histamine receptor H4 0.693311
SSTR2 somatostatin receptor 2 0.688
ADCY2 adenylate cyclase 2 (brain) 0.687592
HNF4A hepatocyte nuclear factor 4, alpha 0.664775
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.663555
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.659491
SST somatostatin 0.649749
VEGFC vascular endothelial growth factor C 0.649749
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.642454
ABAT 4-aminobutyrate aminotransferase 0.636785
AGR3 anterior gradient 3 0.633144
CDC25A cell division cycle 25A 0.625869
PRLR prolactin receptor 0.624254
AGRN agrin 0.61699
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.604502
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.601686
TGFB1 transforming growth factor, beta 1 0.598871
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.591641
HES1 hes family bHLH transcription factor 1 0.590437
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.590437
JAG1 jagged 1 0.588031
CDH22 cadherin 22, type 2 0.587629
HNF1A HNF1 homeobox A 0.583621
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 0.58282
MSR1 macrophage scavenger receptor 1 0.575216
AANAT aralkylamine N-acetyltransferase 0.57042
IL12A interleukin 12A 0.565232
SSTR5 somatostatin receptor 5 0.56284
CLDN1 claudin 1 0.553286
GPC6 glypican 6 0.549312
CD34 CD34 molecule 0.543756
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.540188
TLR4 toll-like receptor 4 0.53346
AGR2 anterior gradient 2 0.532274
IFNLR1 interferon, lambda receptor 1 0.530693
ALPPL2 alkaline phosphatase, placental-like 2 0.522011
ALPL alkaline phosphatase, liver/bone/kidney 0.521617
ALPP alkaline phosphatase, placental 0.520829
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.515317
MAB21L2 mab-21-like 2 (C. elegans) 0.506672
SSTR1 somatostatin receptor 1 0.503141
MIR98 microRNA 98 0.501965
NPNT nephronectin 0.500398
AQP12A aquaporin 12A 0.498048
CFC1 cripto, FRL-1, cryptic family 1 0.497657
SOX17 SRY (sex determining region Y)-box 17 0.497266
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.491009
ITGB4 integrin, beta 4 0.490619
CTSF cathepsin F 0.472315
IL12RB2 interleukin 12 receptor, beta 2 0.460305
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.459918
IL10RB interleukin 10 receptor, beta 0.454898
MET MET proto-oncogene, receptor tyrosine kinase 0.454512
GLP1R glucagon-like peptide 1 receptor 0.448346
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 0.443731
MAPK3 mitogen-activated protein kinase 3 0.442578
CD40 CD40 molecule, TNF receptor superfamily member 5 0.439507
CSRP2 cysteine and glycine-rich protein 2 0.437205
SND1 staphylococcal nuclease and tudor domain containing 1 0.434906
KRT20 keratin 20, type I 0.433374
IGF1R insulin-like growth factor 1 receptor 0.432225
WNT3A wingless-type MMTV integration site family, member 3A 0.430312
SSTR3 somatostatin receptor 3 0.427254
COL9A3 collagen, type IX, alpha 3 0.424199
COL8A1 collagen, type VIII, alpha 1 0.423436
BAX BCL2-associated X protein 0.420385
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.419623
TBX3 T-box 3 0.409731
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.409731
EPHA8 EPH receptor A8 0.409731
FOXA2 forkhead box A2 0.408592
KLB klotho beta 0.407073
ITGA6 integrin, alpha 6 0.406315
GGT2 gamma-glutamyltransferase 2 0.401765
IGKV3-20 immunoglobulin kappa variable 3-20 0.401765
GRP gastrin-releasing peptide 0.397222
ADH6 alcohol dehydrogenase 6 (class V) 0.397222
FKBP7 FK506 binding protein 7 0.390799
FKBP9 FK506 binding protein 9, 63 kDa 0.390799
C9ORF3 chromosome 9 open reading frame 3 0.386273
LAMB1 laminin, beta 1 0.383637
KRT18 keratin 18, type I 0.381379
ESR2 estrogen receptor 2 (ER beta) 0.380627
FKBP6 FK506 binding protein 6, 36kDa 0.380627
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.377245
RIPK4 receptor-interacting serine-threonine kinase 4 0.37687
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.37687
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.375743
HDAC6 histone deacetylase 6 0.373118
DLK1 delta-like 1 homolog (Drosophila) 0.372369
GGT1 gamma-glutamyltransferase 1 0.37087
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.370121
FKBP3 FK506 binding protein 3, 25kDa 0.368998
LAMB2 laminin, beta 2 (laminin S) 0.364886
IGF1 insulin-like growth factor 1 (somatomedin C) 0.363393
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.363393
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.353712
HRH3 histamine receptor H3 0.351485
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.34963
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.346668
CXCR6 chemokine (C-X-C motif) receptor 6 0.346298
TNF tumor necrosis factor 0.342602
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.33744
KRT8 keratin 8, type II 0.336336
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.336336
AQP4 aquaporin 4 0.328994
TYRO3 TYRO3 protein tyrosine kinase 0.32753
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 0.32753
PTCH1 patched 1 0.323874
AQP6 aquaporin 6, kidney specific 0.322779
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.32205
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.32132
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.31877
CDKN2A cyclin-dependent kinase inhibitor 2A 0.318407
RIPK3 receptor-interacting serine-threonine kinase 3 0.317679
SLCO1A2 solute carrier organic anion transporter family, member 1A2 0.312957
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.310059
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.309697
HLX H2.0-like homeobox 0.309697
MIR93 microRNA 93 0.308251
CXCL16 chemokine (C-X-C motif) ligand 16 0.307528
ANXA5 annexin A5 0.306083
RAB25 RAB25, member RAS oncogene family 0.305722
HMX1 H6 family homeobox 1 0.303919
CD40LG CD40 ligand 0.301758
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.298883
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.298524
MAML1 mastermind-like 1 (Drosophila) 0.298165
FKBP10 FK506 binding protein 10, 65 kDa 0.297806
CRY1 cryptochrome circadian clock 1 0.29673
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.295297
LRG1 leucine-rich alpha-2-glycoprotein 1 0.293151
MTNR1A melatonin receptor 1A 0.281423
IFT88 intraflagellar transport 88 0.281423
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.280364
FOXA3 forkhead box A3 0.280012
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 0.279307
NID2 nidogen 2 (osteonidogen) 0.278955
EGFR epidermal growth factor receptor 0.2779
STIP1 stress-induced phosphoprotein 1 0.274744
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.273696
CCND1 cyclin D1 0.272997
SRY sex determining region Y 0.269174
FGFR4 fibroblast growth factor receptor 4 0.268482
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 0.266413
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 0.264353
THY1 Thy-1 cell surface antigen 0.263669
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 0.263327
ESR1 estrogen receptor 1 0.263327
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 0.262986
CLOCK clock circadian regulator 0.259929
RDX radixin 0.259591
DPP4 dipeptidyl-peptidase 4 0.259254
TECR trans-2,3-enoyl-CoA reductase 0.259254
CD163 CD163 molecule 0.257237
NPY1R neuropeptide Y receptor Y1 0.256568
MYD88 myeloid differentiation primary response 88 0.256234
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 0.253248
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 0.253248
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.250301
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.249329
GPR55 G protein-coupled receptor 55 0.248683
GCG glucagon 0.247719
FKBP2 FK506 binding protein 2, 13kDa 0.24486
GPC3 glypican 3 0.244545
STYK1 serine/threonine/tyrosine kinase 1 0.243294
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 0.242363
AQP5 aquaporin 5 0.23961
LAMA5 laminin, alpha 5 0.238406
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.236332
NFIB nuclear factor I/B 0.236332
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.231206
NFIA nuclear factor I/A 0.231206
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.22797
SYNM synemin, intermediate filament protein 0.221989
MSN moesin 0.221521
PARK2 parkin RBR E3 ubiquitin protein ligase 0.219707
CLDN4 claudin 4 0.219485
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.219485
SH2D3A SH2 domain containing 3A 0.219264
MDK midkine (neurite growth-promoting factor 2) 0.219047
TP53 tumor protein p53 0.217346
TJP1 tight junction protein 1 0.216528
EPHA5 EPH receptor A5 0.215147
BCL2L1 BCL2-like 1 0.214576
AQP3 aquaporin 3 (Gill blood group) 0.213471
NCAM1 neural cell adhesion molecule 1 0.213471
JUN jun proto-oncogene 0.213291