cholelithiasis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS). (Experimental Factor Ontology, EFO_0004799)
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Genes

145 genes co-occuring with the disease cholelithiasis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.92201
CCK cholecystokinin 1.72821
SST somatostatin 1.44825
ALPPL2 alkaline phosphatase, placental-like 2 1.44606
ALPP alkaline phosphatase, placental 1.44562
ALPL alkaline phosphatase, liver/bone/kidney 1.44518
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.39171
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.3869
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.35463
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 1.2369
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 1.23169
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.20915
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 1.1588
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 1.08244
GUSB glucuronidase, beta 1.06396
ELOVL6 ELOVL fatty acid elongase 6 1.04966
GGT1 gamma-glutamyltransferase 1 0.9238
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.889258
GLYCAM1 glycosylation dependent cell adhesion molecule 1 (pseudogene) 0.879014
MARS2 methionyl-tRNA synthetase 2, mitochondrial 0.839705
SIK3 SIK family kinase 3 0.833968
HSF4 heat shock transcription factor 4 0.817976
CCKAR cholecystokinin A receptor 0.782298
VMAC vimentin-type intermediate filament associated coiled-coil protein 0.749237
SLC51B solute carrier family 51, beta subunit 0.743954
GAST gastrin 0.728952
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.726524
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.703938
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.697911
IGF1 insulin-like growth factor 1 (somatomedin C) 0.66914
S100A9 S100 calcium binding protein A9 0.668345
PLEK2 pleckstrin 2 0.655254
F2 coagulation factor II (thrombin) 0.650903
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.639463
NCR3 natural cytotoxicity triggering receptor 3 0.588222
MLN motilin 0.581606
PPY pancreatic polypeptide 0.571495
LPA lipoprotein, Lp(a) 0.540829
PDPN podoplanin 0.540442
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 0.536957
HIST1H1D histone cluster 1, H1d 0.530768
ALB albumin 0.529222
INS insulin 0.518034
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.516494
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.50689
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 0.506507
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 0.504207
SCN2A sodium channel, voltage gated, type II alpha subunit 0.500761
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 0.494648
SLCO1A2 solute carrier organic anion transporter family, member 1A2 0.490835
FGF19 fibroblast growth factor 19 0.486266
GGT2 gamma-glutamyltransferase 2 0.467306
FECH ferrochelatase 0.467306
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.466928
F3 coagulation factor III (thromboplastin, tissue factor) 0.456355
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.443171
CP ceruloplasmin (ferroxidase) 0.433772
APOB apolipoprotein B 0.429642
FBL fibrillarin 0.423265
HBB hemoglobin, beta 0.397098
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.396725
CRP C-reactive protein, pentraxin-related 0.396353
REG4 regenerating islet-derived family, member 4 0.388538
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.385936
FABP6 fatty acid binding protein 6, ileal 0.384079
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.377773
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.377402
FBLL1 fibrillarin-like 1 0.368518
SQLE squalene epoxidase 0.367779
HP haptoglobin 0.363716
SLC51A solute carrier family 51, alpha subunit 0.361133
HPR haptoglobin-related protein 0.357814
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 0.357446
CELA1 chymotrypsin-like elastase family, member 1 0.35082
APOA2 apolipoprotein A-II 0.350452
HBD hemoglobin, delta 0.348614
TUBGCP4 tubulin, gamma complex associated protein 4 0.341272
CELA3B chymotrypsin-like elastase family, member 3B 0.340906
ASMT acetylserotonin O-methyltransferase 0.334681
LACTB lactamase, beta 0.331756
APOE apolipoprotein E 0.33066
SCTR secretin receptor 0.32373
MEMO1 mediator of cell motility 1 0.318272
HAL histidine ammonia-lyase 0.315729
MTTP microsomal triglyceride transfer protein 0.301976
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 0.299092
ACTA1 actin, alpha 1, skeletal muscle 0.282582
DMRTA1 DMRT-like family A1 0.28151
UST uronyl-2-sulfotransferase 0.281153
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 0.278654
MUC3A mucin 3A, cell surface associated 0.27794
PKLR pyruvate kinase, liver and RBC 0.277584
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 0.27687
POMP proteasome maturation protein 0.274732
CD79A CD79a molecule, immunoglobulin-associated alpha 0.274376
MYBPC1 myosin binding protein C, slow type 0.272953
AANAT aralkylamine N-acetyltransferase 0.269753
TTR transthyretin 0.26514
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.264785
DKKL1 dickkopf-like 1 0.260184
HDGF hepatoma-derived growth factor 0.258417
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 0.255241
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.249608
CTRC chymotrypsin C (caldecrin) 0.248905
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 0.247852
FTL ferritin, light polypeptide 0.243645
FTH1 ferritin, heavy polypeptide 1 0.243645
MUC2 mucin 2, oligomeric mucus/gel-forming 0.240148
VIP vasoactive intestinal peptide 0.235268
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.230409
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 0.230409
NPC1L1 NPC1-like 1 0.225917
DLD dihydrolipoamide dehydrogenase 0.218034
PKM pyruvate kinase, muscle 0.216672
UBIAD1 UbiA prenyltransferase domain containing 1 0.215653
SPINK1 serine peptidase inhibitor, Kazal type 1 0.215653
PGRMC1 progesterone receptor membrane component 1 0.212608
CSN1S1 casein alpha s1 0.212271
LEP leptin 0.209583
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.207578
CD274 CD274 molecule 0.207245
FLAD1 flavin adenine dinucleotide synthetase 1 0.204593
HEXDC hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing 0.201308
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 0.199681
HBA1 hemoglobin, alpha 1 0.195501
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.192971
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.187415
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.184128
DUT deoxyuridine triphosphatase 0.183835
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 0.182086
VIPR1 vasoactive intestinal peptide receptor 1 0.181798
GCG glucagon 0.178403
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.178403
CYS1 cystin 1 0.178126
HBA2 hemoglobin, alpha 2 0.178126
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 0.177301
CHD1L chromodomain helicase DNA binding protein 1-like 0.175411
HAX1 HCLS1 associated protein X-1 0.171785
CPE carboxypeptidase E 0.171286
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.169571
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.166544
C6ORF25 chromosome 6 open reading frame 25 0.162908
EPCAM epithelial cell adhesion molecule 0.161912
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 0.161523
PTH parathyroid hormone 0.15948