cholesterol metabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. (Gene Ontology, GO_0008203)
External Link http://amigo.geneontology.org/amigo/term/GO:0008203
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Genes

69 genes participating in the cholesterol metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACAA2 acetyl-CoA acyltransferase 2
ACLY ATP citrate lyase
AKR1D1 aldo-keto reductase family 1, member D1
ANGPTL3 angiopoietin-like 3
APOA1 apolipoprotein A-I
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOE apolipoprotein E
APOF apolipoprotein F
APOL2 apolipoprotein L, 2
ARV1 ARV1 homolog (S. cerevisiae)
CES1 carboxylesterase 1
CETP cholesteryl ester transfer protein, plasma
CH25H cholesterol 25-hydroxylase
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDX1 ferredoxin 1
GBA1 glucosylceramidase beta 1
GBA2 glucosidase, beta (bile acid) 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IL4 interleukin 4
INSIG1 insulin induced gene 1
INSIG2 insulin induced gene 2
LBR lamin B receptor
LCAT lecithin-cholesterol acyltransferase
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LMBR1 limb development membrane protein 1
MSMO1 methylsterol monooxygenase 1
MVD mevalonate (diphospho) decarboxylase
MVK mevalonate kinase
NPC1L1 NPC1-like 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
OSBPL1A oxysterol binding protein-like 1A
OSBPL5 oxysterol binding protein-like 5
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
PLPP6 phospholipid phosphatase 6
PMVK phosphomevalonate kinase
PPARD peroxisome proliferator-activated receptor delta
SCAP SREBF chaperone
SCARF1 scavenger receptor class F, member 1
SH3D19 SH3 domain containing 19
SNX17 sorting nexin 17
SOAT1 sterol O-acyltransferase 1
SOAT2 sterol O-acyltransferase 2
SQLE squalene epoxidase
STARD3 StAR-related lipid transfer (START) domain containing 3
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TM7SF2 transmembrane 7 superfamily member 2
TSKU tsukushi, small leucine rich proteoglycan
UBL4A ubiquitin-like 4A