The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. (Gene Ontology, GO_0030206)
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17 proteins participating in the chondroitin sulfate biosynthesis pathway from the KEGG Pathways dataset.