chondroitin sulfate metabolic process Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate. (Gene Ontology, GO_0030204)
External Link http://amigo.geneontology.org/amigo/term/GO:0030204
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Genes

58 genes participating in the chondroitin sulfate metabolic process biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AGRN agrin
ARSB arylsulfatase B
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
B3GAT1 beta-1,3-glucuronyltransferase 1
B3GAT2 beta-1,3-glucuronyltransferase 2
B3GAT3 beta-1,3-glucuronyltransferase 3
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
BCAN brevican
BGN biglycan
CHPF chondroitin polymerizing factor
CHPF2 chondroitin polymerizing factor 2
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CHST13 carbohydrate (chondroitin 4) sulfotransferase 13
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
CHSY1 chondroitin sulfate synthase 1
CHSY3 chondroitin sulfate synthase 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSPG4 chondroitin sulfate proteoglycan 4
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
DCN decorin
DSE dermatan sulfate epimerase
DSEL dermatan sulfate epimerase-like
EGFLAM EGF-like, fibronectin type III and laminin G domains
GPC1 glypican 1
GPC2 glypican 2
GPC3 glypican 3
GPC4 glypican 4
GPC5 glypican 5
GPC6 glypican 6
GXYLT1 glucoside xylosyltransferase 1
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HSPG2 heparan sulfate proteoglycan 2
HYAL1 hyaluronoglucosaminidase 1
HYAL4 hyaluronoglucosaminidase 4
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IMPAD1 inositol monophosphatase domain containing 1
MAMDC2 MAM domain containing 2
NCAN neurocan
NDNF neuron-derived neurotrophic factor
SDC1 syndecan 1
SDC2 syndecan 2
SDC3 syndecan 3
SDC4 syndecan 4
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
UST uronyl-2-sulfotransferase
VCAN versican
XYLT1 xylosyltransferase I
XYLT2 xylosyltransferase II
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