chondrosarcoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)|A malignant mesenchymal tumor arising from cartilage-forming tissues involving the bones. It affects middle-aged to elderly adults, and the pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion. (Experimental Factor Ontology, EFO_0000333)
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Genes

348 genes co-occuring with the disease chondrosarcoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
EWSR1 EWS RNA-binding protein 1 1.92014
EXT2 exostosin glycosyltransferase 2 1.90288
NR4A3 nuclear receptor subfamily 4, group A, member 3 1.83274
EXT1 exostosin glycosyltransferase 1 1.80201
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 1.68317
ACAN aggrecan 1.6624
SOX9 SRY (sex determining region Y)-box 9 1.29877
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1.24776
FMNL2 formin-like 2 1.22172
LECT1 leukocyte cell derived chemotaxin 1 1.21175
IHH indian hedgehog 1.20915
FMNL1 formin-like 1 1.19661
DAAM2 dishevelled associated activator of morphogenesis 2 1.18453
TFG TRK-fused gene 1.14942
FMNL3 formin-like 3 1.1422
FHDC1 FH2 domain containing 1 1.13585
DIAPH2 diaphanous-related formin 2 1.12909
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.12235
COL2A1 collagen, type II, alpha 1 1.09881
TP53 tumor protein p53 1.07824
FHOD1 formin homology 2 domain containing 1 1.06732
FAM195A family with sequence similarity 195, member A 1.06648
ENO2 enolase 2 (gamma, neuronal) 1.0627
DAAM1 dishevelled associated activator of morphogenesis 1 1.06144
TCF12 transcription factor 12 1.05892
MMP13 matrix metallopeptidase 13 1.05765
FAM86DP family with sequence similarity 86, member D, pseudogene 1.05555
DIAPH1 diaphanous-related formin 1 1.05219
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.994861
TMEM30C transmembrane protein 30C 0.988535
COL27A1 collagen, type XXVII, alpha 1 0.982636
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.982636
MMP1 matrix metallopeptidase 1 0.964148
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.959123
NCOA2 nuclear receptor coactivator 2 0.953273
YEATS2 YEATS domain containing 2 0.937044
CSAG2 CSAG family, member 2 0.922149
CSAG3 CSAG family, member 3 0.922149
CTGF connective tissue growth factor 0.916787
FMN2 formin 2 0.899924
PTHLH parathyroid hormone-like hormone 0.894179
FGF1 fibroblast growth factor 1 (acidic) 0.889668
CSAG1 chondrosarcoma associated gene 1 0.852402
FNBP1 formin binding protein 1 0.844621
ARHGAP23 Rho GTPase activating protein 23 0.840115
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.806077
ARHGAP12 Rho GTPase activating protein 12 0.803616
MTAP methylthioadenosine phosphorylase 0.798692
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.795411
FMN1 formin 1 0.788852
CD99 CD99 molecule 0.788442
DIAPH3 diaphanous-related formin 3 0.785984
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.776977
ARHGAP10 Rho GTPase activating protein 10 0.772479
GLI2 GLI family zinc finger 2 0.772479
CHAD chondroadherin 0.768393
CDKN2A cyclin-dependent kinase inhibitor 2A 0.764718
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.763902
FUS FUS RNA binding protein 0.74761
MMP2 matrix metallopeptidase 2 0.742329
ARHGAP25 Rho GTPase activating protein 25 0.738676
SYP synaptophysin 0.738676
BAX BCL2-associated X protein 0.728952
GLI1 GLI family zinc finger 1 0.714811
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.707157
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.705949
MYOG myogenin (myogenic factor 4) 0.70233
ARHGAP19 Rho GTPase activating protein 19 0.70233
FNBP4 formin binding protein 4 0.701526
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.699116
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.698715
CREB3L2 cAMP responsive element binding protein 3-like 2 0.6939
SS18 synovial sarcoma translocation, chromosome 18 0.683493
ARHGAP4 Rho GTPase activating protein 4 0.679499
COMP cartilage oligomeric matrix protein 0.678701
ADAMTSL1 ADAMTS-like 1 0.673518
CD44 CD44 molecule (Indian blood group) 0.669936
C11ORF95 chromosome 11 open reading frame 95 0.668742
ALPPL2 alkaline phosphatase, placental-like 2 0.668345
ALPP alkaline phosphatase, placental 0.667947
ALPL alkaline phosphatase, liver/bone/kidney 0.667152
GMIP GEM interacting protein 0.664372
GPR78 G protein-coupled receptor 78 0.650113
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.641827
ARHGAP15 Rho GTPase activating protein 15 0.639463
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 0.636708
FGFR3 fibroblast growth factor receptor 3 0.632384
MB myoglobin 0.631205
CDK4 cyclin-dependent kinase 4 0.62728
ARHGAP22 Rho GTPase activating protein 22 0.62728
ARHGAP17 Rho GTPase activating protein 17 0.624927
BCL2L1 BCL2-like 1 0.616703
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.614356
HAPLN1 hyaluronan and proteoglycan link protein 1 0.612401
ARHGAP20 Rho GTPase activating protein 20 0.610057
NPM3 nucleophosmin/nucleoplasmin 3 0.604591
NUP107 nucleoporin 107kDa 0.604591
ARHGAP9 Rho GTPase activating protein 9 0.604201
PTCH1 patched 1 0.59952
DAP3 death associated protein 3 0.596792
CDC50B cell division cycle 50 P4-ATPase accessory subunit B 0.595623
CD34 CD34 molecule 0.581606
B3GAT1 beta-1,3-glucuronyltransferase 1 0.575772
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 0.571107
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.566831
IFT88 intraflagellar transport 88 0.562558
MYOD1 myogenic differentiation 1 0.561392
PDCD5 programmed cell death 5 0.556344
BMP7 bone morphogenetic protein 7 0.556344
EPYC epiphycan 0.55518
AMBP alpha-1-microglobulin/bikunin precursor 0.551686
KRT8 keratin 8, type II 0.550522
M6PR mannose-6-phosphate receptor (cation dependent) 0.546644
FGF2 fibroblast growth factor 2 (basic) 0.545868
RAI14 retinoic acid induced 14 0.536957
ARHGAP24 Rho GTPase activating protein 24 0.535022
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.534248
ETV5 ets variant 5 0.531154
CTAG1A cancer/testis antigen 1A 0.52729
CCNB3 cyclin B3 0.522659
LGALS4 lectin, galactoside-binding, soluble, 4 0.521502
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.519961
ARHGAP21 Rho GTPase activating protein 21 0.516879
MMP9 matrix metallopeptidase 9 0.514956
CTAG1B cancer/testis antigen 1B 0.513417
ALX1 ALX homeobox 1 0.508424
BCAN brevican 0.506507
CDH19 cadherin 19, type 2 0.505739
ARHGAP5 Rho GTPase activating protein 5 0.504973
DACT2 dishevelled-binding antagonist of beta-catenin 2 0.50459
PARVB parvin, beta 0.491215
ARHGAP6 Rho GTPase activating protein 6 0.489311
DDIT3 DNA-damage-inducible transcript 3 0.488169
NOV nephroblastoma overexpressed 0.486646
TGFB1 transforming growth factor, beta 1 0.480186
MOCS1 molybdenum cofactor synthesis 1 0.477151
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.475634
RHOU ras homolog family member U 0.474119
CD24 CD24 molecule 0.473361
SMO smoothened, frizzled class receptor 0.472604
FN1 fibronectin 1 0.466172
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.466172
MATN1 matrilin 1, cartilage matrix protein 0.465038
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 0.46466
WISP1 WNT1 inducible signaling pathway protein 1 0.462394
EXTL2 exostosin-like glycosyltransferase 2 0.462394
MKL2 MKL/myocardin-like 2 0.462016
STARD8 StAR-related lipid transfer (START) domain containing 8 0.461261
COL12A1 collagen, type XII, alpha 1 0.456732
COL10A1 collagen, type X, alpha 1 0.455601
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.455224
ARHGAP1 Rho GTPase activating protein 1 0.453716
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.453339
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.447311
RUNX2 runt-related transcription factor 2 0.446558
CDX1 caudal type homeobox 1 0.445052
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 0.442418
COL11A2 collagen, type XI, alpha 2 0.442418
FRS2 fibroblast growth factor receptor substrate 2 0.436026
ARHGAP26 Rho GTPase activating protein 26 0.43227
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.428516
DNM3 dynamin 3 0.42289
JUN jun proto-oncogene 0.418019
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.417644
LXN latexin 0.412405
CYR61 cysteine-rich, angiogenic inducer, 61 0.412031
PCNA proliferating cell nuclear antigen 0.405305
KRT7 keratin 7, type II 0.404931
TFEC transcription factor EC 0.403064
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.401572
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.400453
TNC tenascin C 0.40008
CCND1 cyclin D1 0.398962
NCAM1 neural cell adhesion molecule 1 0.397843
TIMP2 TIMP metallopeptidase inhibitor 2 0.397471
CALCB calcitonin-related polypeptide beta 0.394863
YEATS4 YEATS domain containing 4 0.388909
CLTB clathrin, light chain B 0.379626
MET MET proto-oncogene, receptor tyrosine kinase 0.378885
DNER delta/notch-like EGF repeat containing 0.377773
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.376661
PARD3 par-3 family cell polarity regulator 0.37592
RACGAP1 Rac GTPase activating protein 1 0.372587
PRAME preferentially expressed antigen in melanoma 0.371107
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.365932
EMILIN1 elastin microfibril interfacer 1 0.362239
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.356341
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.353763
SSX1 synovial sarcoma, X breakpoint 1 0.353395
PLAU plasminogen activator, urokinase 0.351555
ITM2B integral membrane protein 2B 0.346409
BGN biglycan 0.346409
EXTL1 exostosin-like glycosyltransferase 1 0.34384
LGALS7 lectin, galactoside-binding, soluble, 7 0.34384
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.337242
FGF17 fibroblast growth factor 17 0.33651
SIX3 SIX homeobox 3 0.335412
FOXL1 forkhead box L1 0.333949
PRRC2A proline-rich coiled-coil 2A 0.333218
CALD1 caldesmon 1 0.3292
GFAP glial fibrillary acidic protein 0.325187
CHGA chromogranin A 0.32373
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.321181
CHN2 chimerin 2 0.317909
CTSS cathepsin S 0.312827
CHN1 chimerin 1 0.309928
FZD8 frizzled class receptor 8 0.309566
FZD9 frizzled class receptor 9 0.30342
AGO2 argonaute RISC catalytic component 2 0.30342
RAB38 RAB38, member RAS oncogene family 0.302698
IGF1 insulin-like growth factor 1 (somatomedin C) 0.300533
HBA1 hemoglobin, alpha 1 0.298011
TRIP10 thyroid hormone receptor interactor 10 0.292257
FZD5 frizzled class receptor 5 0.29118
HBA2 hemoglobin, alpha 2 0.277584
MCM6 minichromosome maintenance complex component 6 0.275445
TAS1R1 taste receptor, type 1, member 1 0.273664
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.272597
TANK TRAF family member-associated NFKB activator 0.269043
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.266558
MMP3 matrix metallopeptidase 3 0.266203
MMP12 matrix metallopeptidase 12 0.26266
ETV4 ets variant 4 0.260891
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.260184
DCN decorin 0.260184
BIN3 bridging integrator 3 0.256299
ADGRG1 adhesion G protein-coupled receptor G1 0.254183
CDC27 cell division cycle 27 0.250311
ZBTB7A zinc finger and BTB domain containing 7A 0.24996
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.24996
ANGPTL2 angiopoietin-like 2 0.249257
PPARG peroxisome proliferator-activated receptor gamma 0.246799
S100P S100 calcium binding protein P 0.244696
PDPN podoplanin 0.243645
GLB1 galactosidase, beta 1 0.242945
FGF8 fibroblast growth factor 8 (androgen-induced) 0.241895
VAMP8 vesicle-associated membrane protein 8 0.241546
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.240847
FZD6 frizzled class receptor 6 0.240497
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 0.240148
CXCL12 chemokine (C-X-C motif) ligand 12 0.240148
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.239101
COL9A1 collagen, type IX, alpha 1 0.235268
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.230409
FZD2 frizzled class receptor 2 0.229716
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.228333
BGLAP bone gamma-carboxyglutamate (gla) protein 0.227642
SFTPC surfactant protein C 0.226607
PRKCD protein kinase C, delta 0.226607
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.222136
ANXA5 annexin A5 0.220766
NOTCH1 notch 1 0.220766
PAX7 paired box 7 0.21974
CD1A CD1a molecule 0.218374
HSPA1A heat shock 70kDa protein 1A 0.214975
E2F3 E2F transcription factor 3 0.211597
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.211261
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 0.210253
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.208914
SDC2 syndecan 2 0.206913
NT5E 5'-nucleotidase, ecto (CD73) 0.206248
PROS2P protein S (beta) pseudogene 0.205585
CTSB cathepsin B 0.20229
ARHGAP18 Rho GTPase activating protein 18 0.201308
TSN translin 0.200006
TGFB3 transforming growth factor, beta 3 0.199356
INS insulin 0.198709
MMP19 matrix metallopeptidase 19 0.198386
CD68 CD68 molecule 0.196139
VEGFA vascular endothelial growth factor A 0.196139
CSPG4 chondroitin sulfate proteoglycan 4 0.193915
PARD6A par-6 family cell polarity regulator alpha 0.193915
FGF19 fibroblast growth factor 19 0.192971
SULF2 sulfatase 2 0.192344
IFI16 interferon, gamma-inducible protein 16 0.189859
PARVA parvin, alpha 0.188022
TIMP1 TIMP metallopeptidase inhibitor 1 0.18472
COL4A2 collagen, type IV, alpha 2 0.182375
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.181222
PRKG1 protein kinase, cGMP-dependent, type I 0.181222
CHEK2 checkpoint kinase 2 0.179239
ILK integrin-linked kinase 0.177851
VCAN versican 0.176215
PRKCZ protein kinase C, zeta 0.175679
PLAGL1 pleiomorphic adenoma gene-like 1 0.175411
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.175411
MDK midkine (neurite growth-promoting factor 2) 0.173832
BMP2 bone morphogenetic protein 2 0.173571
DAD1 defender against cell death 1 0.172799
RB1 retinoblastoma 1 0.171286
INSC inscuteable homolog (Drosophila) 0.169571
CTAG2 cancer/testis antigen 2 0.168148
NCAN neurocan 0.164359
POT1 protection of telomeres 1 0.163729
MIR96 microRNA 96 0.163111
RORA RAR-related orphan receptor A 0.162109
EZR ezrin 0.161139
ACVR2A activin A receptor, type IIA 0.160574
TGFBR3 transforming growth factor, beta receptor III 0.160021
F8 coagulation factor VIII, procoagulant component 0.159838
CORIN corin, serine peptidase 0.158434
HDAC9 histone deacetylase 9 0.158266
TES testin LIM domain protein 0.157929
FOS FBJ murine osteosarcoma viral oncogene homolog 0.157929
NKX2-2 NK2 homeobox 2 0.15537
KRT6A keratin 6A, type II 0.143947
NDRG2 NDRG family member 2 0.143784
CLCN3 chloride channel, voltage-sensitive 3 0.143754
PLAG1 pleiomorphic adenoma gene 1 0.143748
ETV1 ets variant 1 0.143446
KITLG KIT ligand 0.143407
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.142678
NAPSA napsin A aspartic peptidase 0.142474
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.141928
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.141918
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.140931
TOP2A topoisomerase (DNA) II alpha 170kDa 0.140755
NEFH neurofilament, heavy polypeptide 0.140422
CREB1 cAMP responsive element binding protein 1 0.140084
TBP TATA box binding protein 0.139647
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.139622
ACTA1 actin, alpha 1, skeletal muscle 0.139459
SOX10 SRY (sex determining region Y)-box 10 0.139412
FASN fatty acid synthase 0.139336
MKI67 marker of proliferation Ki-67 0.138889
MYH11 myosin, heavy chain 11, smooth muscle 0.136367
WT1 Wilms tumor 1 0.136205
SIK1 salt-inducible kinase 1 0.125891
VIM vimentin 0.124392
PAX3 paired box 3 0.124063
LYZ lysozyme 0.122833
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.122106
SRY sex determining region Y 0.117692
KRT20 keratin 20, type I 0.110077
ASS1 argininosuccinate synthase 1 0.109279
SCN2A sodium channel, voltage gated, type II alpha subunit 0.106645
MFGE8 milk fat globule-EGF factor 8 protein 0.105314
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.103164
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.102753
PTPRC protein tyrosine phosphatase, receptor type, C 0.10142
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.101109
NGFR nerve growth factor receptor 0.098153
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.095602
CD4 CD4 molecule 0.095346
DHFR dihydrofolate reductase 0.094354
PTH parathyroid hormone 0.093439
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.090203
GPC3 glypican 3 0.090065