chondrosarcoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)|A malignant mesenchymal tumor arising from cartilage-forming tissues involving the bones. It affects middle-aged to elderly adults, and the pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion. (Experimental Factor Ontology, EFO_0000333)
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Genes

113 genes co-occuring with the biological term chondrosarcoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADAM28 ADAM metallopeptidase domain 28
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AURKA aurora kinase A
AURKB aurora kinase B
BCL2L1 BCL2-like 1
BDKRB1 bradykinin receptor B1
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BMP2 bone morphogenetic protein 2
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CD24 CD24 molecule
CD40LG CD40 ligand
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX1 caudal type homeobox 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CTAG2 cancer/testis antigen 2
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
EDN1 endothelin 1
EGFR epidermal growth factor receptor
ENG endoglin
EPAS1 endothelial PAS domain protein 1
ETV5 ets variant 5
ETV6 ets variant 6
EWSR1 EWS RNA-binding protein 1
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
F2R coagulation factor II (thrombin) receptor
F2RL3 coagulation factor II (thrombin) receptor-like 3
FGFR2 fibroblast growth factor receptor 2
GADD45B growth arrest and DNA-damage-inducible, beta
GLI1 GLI family zinc finger 1
HDAC4 histone deacetylase 4
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF1 insulin-like growth factor 1 (somatomedin C)
IL11 interleukin 11
IL1B interleukin 1, beta
IL6 interleukin 6
INHBA inhibin, beta A
IRF2BP2 interferon regulatory factor 2 binding protein 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
KNG1 kininogen 1
LDHA lactate dehydrogenase A
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR100 microRNA 100
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCOA2 nuclear receptor coactivator 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOV nephroblastoma overexpressed
PDCD5 programmed cell death 5
PDPN podoplanin
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAG1 pleiomorphic adenoma gene 1
PLAGL1 pleiomorphic adenoma gene-like 1
PPARG peroxisome proliferator-activated receptor gamma
PRAME preferentially expressed antigen in melanoma
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCD protein kinase C, delta
PTCH1 patched 1
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
RB1 retinoblastoma 1
RUNX2 runt-related transcription factor 2
RUNX3 runt-related transcription factor 3
SMAD1 SMAD family member 1
SMO smoothened, frizzled class receptor
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
TERT telomerase reverse transcriptase
TFG TRK-fused gene
TGFB1 transforming growth factor, beta 1
TNC tenascin C
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
VEGFA vascular endothelial growth factor A
WISP1 WNT1 inducible signaling pathway protein 1
WISP3 WNT1 inducible signaling pathway protein 3
ZBTB7A zinc finger and BTB domain containing 7A