choriocarcinoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected. (Experimental Factor Ontology, EFO_0002893)
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Genes

335 genes co-occuring with the disease choriocarcinoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CSH2 chorionic somatomammotropin hormone 2 2.28994
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.27532
LGALS1 lectin, galactoside-binding, soluble, 1 1.59117
AFP alpha-fetoprotein 1.56755
PSG9 pregnancy specific beta-1-glycoprotein 9 1.46671
STARD7 StAR-related lipid transfer (START) domain containing 7 1.35986
HLA-G major histocompatibility complex, class I, G 1.29658
ERV3-1 endogenous retrovirus group 3, member 1 1.24081
GCH1 GTP cyclohydrolase 1 1.21868
GH2 growth hormone 2 1.20396
ZNF184 zinc finger protein 184 1.06774
INHA inhibin, alpha 1.05471
ZNHIT2 zinc finger, HIT-type containing 2 1.04882
ALPPL2 alkaline phosphatase, placental-like 2 1.0383
ALPP alkaline phosphatase, placental 1.0324
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.01891
ALPL alkaline phosphatase, liver/bone/kidney 1.01427
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 1.01216
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.952856
CGB chorionic gonadotropin, beta polypeptide 0.935385
ENDOU endonuclease, polyU-specific 0.929587
CTSC cathepsin C 0.888438
FBXW8 F-box and WD repeat domain containing 8 0.882701
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.869596
CGA glycoprotein hormones, alpha polypeptide 0.865912
LNPEP leucyl/cystinyl aminopeptidase 0.859771
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.859362
GH1 growth hormone 1 0.858543
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.841753
NANOG Nanog homeobox 0.835607
CPM carboxypeptidase M 0.827409
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 0.824128
CGB8 chorionic gonadotropin, beta polypeptide 8 0.817155
ERVW-1 endogenous retrovirus group W, member 1 0.816745
DHFR dihydrofolate reductase 0.795411
GPC3 glypican 3 0.762678
SOX17 SRY (sex determining region Y)-box 17 0.757786
F2R coagulation factor II (thrombin) receptor 0.755342
CUL7 cullin 7 0.74761
MCAM melanoma cell adhesion molecule 0.743547
LVRN laeverin 0.741923
SOX2 SRY (sex determining region Y)-box 2 0.740299
HOXB6 homeobox B6 0.735433
TEAD3 TEA domain family member 3 0.72612
GATAD1 GATA zinc finger domain containing 1 0.708767
GCM1 glial cells missing homolog 1 (Drosophila) 0.707559
KATNA1 katanin p60 (ATPase containing) subunit A 1 0.696306
EBF4 early B-cell factor 4 0.692296
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.687891
TFPI2 tissue factor pathway inhibitor 2 0.685491
TP53 tumor protein p53 0.682693
POU5F1 POU class 5 homeobox 1 0.681096
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.681096
HSPE1 heat shock 10kDa protein 1 0.677504
DSCR4 Down syndrome critical region 4 0.664372
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.663578
TCL1A T-cell leukemia/lymphoma 1A 0.651694
HPSE heparanase 0.648533
PZP pregnancy-zone protein 0.641039
GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2, pseudogene 0.639857
SNTG1 syntrophin, gamma 1 0.624143
SALL4 spalt-like transcription factor 4 0.624143
CTBS chitobiase, di-N-acetyl- 0.621008
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.620617
ASCL2 achaete-scute family bHLH transcription factor 2 0.615529
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.614747
PGF placental growth factor 0.612401
HOXC6 homeobox C6 0.610448
SYNE1 spectrin repeat containing, nuclear envelope 1 0.603811
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.60225
NCAPG non-SMC condensin I complex, subunit G 0.6003
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.59913
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.596792
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.579661
RASGEF1A RasGEF domain family, member 1A 0.57655
HLA-A major histocompatibility complex, class I, A 0.5645
PAEP progestagen-associated endometrial protein 0.562558
TGFB1 transforming growth factor, beta 1 0.561781
NFE2L3 nuclear factor, erythroid 2-like 3 0.560616
PTN pleiotrophin 0.558285
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.540442
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.540055
LEP leptin 0.538118
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.535022
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.534248
HOXA11 homeobox A11 0.533861
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 0.533475
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.528835
CSF1R colony stimulating factor 1 receptor 0.524588
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.524588
PRL prolactin 0.515725
AURKB aurora kinase B 0.512264
NCR2 natural cytotoxicity triggering receptor 2 0.509959
IGF2 insulin-like growth factor 2 0.505739
ANXA5 annexin A5 0.495029
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 0.490835
ERBB2 erb-b2 receptor tyrosine kinase 2 0.485505
LGALS7 lectin, galactoside-binding, soluble, 7 0.483985
SMAD3 SMAD family member 3 0.483224
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.479047
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 0.477909
NEK2 NIMA-related kinase 2 0.470332
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.467684
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.465038
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.46466
RRM2 ribonucleotide reductase M2 0.460129
GNRHR gonadotropin-releasing hormone receptor 0.457864
LHCGR luteinizing hormone/choriogonadotropin receptor 0.454093
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.449194
MUC15 mucin 15, cell surface associated 0.447687
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.444676
HOXB7 homeobox B7 0.442795
NCR3 natural cytotoxicity triggering receptor 3 0.440538
TEAD4 TEA domain family member 4 0.437154
PPME1 protein phosphatase methylesterase 1 0.430768
GPER1 G protein-coupled estrogen receptor 1 0.42364
NEK8 NIMA-related kinase 8 0.421765
JUN jun proto-oncogene 0.419892
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.419517
KIF7 kinesin family member 7 0.416521
HMGA1 high mobility group AT-hook 1 0.41465
EFNA4 ephrin-A4 0.414276
CDX2 caudal type homeobox 2 0.412405
ZFYVE1 zinc finger, FYVE domain containing 1 0.40904
BOK BCL2-related ovarian killer 0.40904
POU5F1B POU class 5 homeobox 1B 0.402692
GATA2 GATA binding protein 2 0.401945
ESRRA estrogen-related receptor alpha 0.401945
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.399707
SPATA7 spermatogenesis associated 7 0.39598
LEPR leptin receptor 0.393374
SP1 Sp1 transcription factor 0.392629
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.388538
NMUR2 neuromedin U receptor 2 0.388166
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 0.387423
HLA-C major histocompatibility complex, class I, C 0.383337
PTPRS protein tyrosine phosphatase, receptor type, S 0.382223
PCTP phosphatidylcholine transfer protein 0.377402
DNASE1 deoxyribonuclease I 0.377031
UTF1 undifferentiated embryonic cell transcription factor 1 0.376661
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.37555
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.371477
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.370368
PCBP1 poly(rC) binding protein 1 0.369628
MNX1 motor neuron and pancreas homeobox 1 0.368149
KRT7 keratin 7, type II 0.36704
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.365932
ERBB4 erb-b2 receptor tyrosine kinase 4 0.360395
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 0.359289
CDC123 cell division cycle 123 0.357077
TF transferrin 0.352659
KRT18 keratin 18, type I 0.348981
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.346409
MCM7 minichromosome maintenance complex component 7 0.344574
TIMP3 TIMP metallopeptidase inhibitor 3 0.342372
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.340173
ERH enhancer of rudimentary homolog (Drosophila) 0.332852
FOXF2 forkhead box F2 0.328834
LAP3 leucine aminopeptidase 3 0.323365
FURIN furin (paired basic amino acid cleaving enzyme) 0.323365
CTSZ cathepsin Z 0.323002
NR2F6 nuclear receptor subfamily 2, group F, member 6 0.321909
PCNA proliferating cell nuclear antigen 0.319726
HAUS3 HAUS augmin-like complex, subunit 3 0.318272
IL1B interleukin 1, beta 0.317909
CNOT2 CCR4-NOT transcription complex, subunit 2 0.316819
PDLIM5 PDZ and LIM domain 5 0.313552
GDF3 growth differentiation factor 3 0.311377
HMP19 HMP19 protein 0.311014
EGFR epidermal growth factor receptor 0.305948
AKR1C3 aldo-keto reductase family 1, member C3 0.305226
POLR1D polymerase (RNA) I polypeptide D, 16kDa 0.303781
FN1 fibronectin 1 0.297651
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.297291
THRA thyroid hormone receptor, alpha 0.287593
TGFB3 transforming growth factor, beta 3 0.285444
IK IK cytokine, down-regulator of HLA II 0.284728
ERBB3 erb-b2 receptor tyrosine kinase 3 0.284371
PLIN2 perilipin 2 0.281868
SIGMAR1 sigma non-opioid intracellular receptor 1 0.28151
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 0.28151
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.280796
CDKN2A cyclin-dependent kinase inhibitor 2A 0.280082
DLX4 distal-less homeobox 4 0.280082
PTTG1 pituitary tumor-transforming 1 0.279011
B2M beta-2-microglobulin 0.278297
NID1 nidogen 1 0.27794
RNF31 ring finger protein 31 0.277584
CSHL1 chorionic somatomammotropin hormone-like 1 0.276158
WASH7P WAS protein family homolog 7 pseudogene 0.272597
NCR1 natural cytotoxicity triggering receptor 1 0.269753
WASH1 WAS protein family homolog 1 0.269043
LDHC lactate dehydrogenase C 0.266558
WASH6P WAS protein family homolog 6 pseudogene 0.266558
ESR1 estrogen receptor 1 0.26514
SDC3 syndecan 3 0.263722
GPR162 G protein-coupled receptor 162 0.263014
RXRA retinoid X receptor, alpha 0.262306
LAMA2 laminin, alpha 2 0.260184
TAGLN2 transgelin 2 0.258417
MME membrane metallo-endopeptidase 0.257358
ACOT1 acyl-CoA thioesterase 1 0.256652
MCM4 minichromosome maintenance complex component 4 0.253479
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.25207
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.24715
ASMT acetylserotonin O-methyltransferase 0.23945
SYN2 synapsin II 0.23945
DCN decorin 0.239101
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 0.238752
STS steroid sulfatase (microsomal), isozyme S 0.237706
ESRRB estrogen-related receptor beta 0.237357
GJA5 gap junction protein, alpha 5, 40kDa 0.237009
GALP galanin-like peptide 0.23666
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.23353
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.232836
TIMP1 TIMP metallopeptidase inhibitor 1 0.230063
CAPN1 calpain 1, (mu/I) large subunit 0.230063
DIO3 deiodinase, iodothyronine, type III 0.230063
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.229024
CALR calreticulin 0.225917
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.223165
CGB7 chorionic gonadotropin, beta polypeptide 7 0.22145
CGB5 chorionic gonadotropin, beta polypeptide 5 0.220081
ASCL3 achaete-scute family bHLH transcription factor 3 0.218715
DNTT DNA nucleotidylexotransferase 0.217693
PI3 peptidase inhibitor 3, skin-derived 0.214636
S100P S100 calcium binding protein P 0.213621
MCM6 minichromosome maintenance complex component 6 0.212945
PDGFB platelet-derived growth factor beta polypeptide 0.210925
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 0.208245
HAPLN1 hyaluronan and proteoglycan link protein 1 0.207245
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.202946
FLT1 fms-related tyrosine kinase 1 0.200331
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 0.200006
DIO1 deiodinase, iodothyronine, type I 0.198709
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.198386
CENPV centromere protein V 0.19582
TMEM245 transmembrane protein 245 0.194232
PARD6A par-6 family cell polarity regulator alpha 0.193915
FGF4 fibroblast growth factor 4 0.189551
PEX1 peroxisomal biogenesis factor 1 0.189244
HRAS Harvey rat sarcoma viral oncogene homolog 0.188938
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 0.188326
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 0.187719
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.18651
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.185612
JAK2 Janus kinase 2 0.185016
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.183835
DUSP5 dual specificity phosphatase 5 0.183541
OSM oncostatin M 0.183248
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.181222
AANAT aralkylamine N-acetyltransferase 0.180652
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.17896
CLIC1 chloride intracellular channel 1 0.175146
ACTG1 actin gamma 1 0.170054
GPC1 glypican 1 0.168148
PNMA2 paraneoplastic Ma antigen 2 0.167682
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.167452
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.166995
RAET1E retinoic acid early transcript 1E 0.166319
MMP2 matrix metallopeptidase 2 0.166319
SYN3 synapsin III 0.166095
DNM1 dynamin 1 0.163111
HES4 hes family bHLH transcription factor 4 0.161331
TNF tumor necrosis factor 0.161139
RPS6 ribosomal protein S6 0.160387
DNAH8 dynein, axonemal, heavy chain 8 0.160021
TFRC transferrin receptor 0.158778
HOPX HOP homeobox 0.158778
FUT2 fucosyltransferase 2 (secretor status included) 0.158778
MMP10 matrix metallopeptidase 10 0.157765
SRY sex determining region Y 0.146393
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.142785
PCSK6 proprotein convertase subtilisin/kexin type 6 0.142772
CUTA cutA divalent cation tolerance homolog (E. coli) 0.142602
RGN regucalcin 0.142192
HES2 hes family bHLH transcription factor 2 0.142034
PCSK7 proprotein convertase subtilisin/kexin type 7 0.141373
PAOX polyamine oxidase (exo-N4-amino) 0.14134
ACSL6 acyl-CoA synthetase long-chain family member 6 0.14129
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.141186
NFE2 nuclear factor, erythroid 2 0.141043
ERAP1 endoplasmic reticulum aminopeptidase 1 0.141043
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.139461
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.139145
PLIN1 perilipin 1 0.139106
ACSL5 acyl-CoA synthetase long-chain family member 5 0.138591
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.138308
ACTB actin, beta 0.137465
WNT5A wingless-type MMTV integration site family, member 5A 0.136803
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.136124
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.136077
FGF19 fibroblast growth factor 19 0.135805
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.13461
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.133792
LDHA lactate dehydrogenase A 0.133562
ACSL4 acyl-CoA synthetase long-chain family member 4 0.133242
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.132047
ENO2 enolase 2 (gamma, neuronal) 0.131508
PTER phosphotriesterase related 0.131464
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.12947
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 0.12927
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.128371
MUC3A mucin 3A, cell surface associated 0.128342
SOX3 SRY (sex determining region Y)-box 3 0.126698
FOXD3 forkhead box D3 0.124983
ZNF185 zinc finger protein 185 (LIM domain) 0.124493
MEGF6 multiple EGF-like-domains 6 0.124379
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 0.124107
HHAT hedgehog acyltransferase 0.123692
RPSA ribosomal protein SA 0.122699
CD200 CD200 molecule 0.122486
FASLG Fas ligand (TNF superfamily, member 6) 0.120346
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.120226
HAS2 hyaluronan synthase 2 0.119985
FOSL1 FOS-like antigen 1 0.119612
JUND jun D proto-oncogene 0.117002
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.116917
MUC4 mucin 4, cell surface associated 0.111642
PARK7 parkinson protein 7 0.110473
CCNA2 cyclin A2 0.109191
F10 coagulation factor X 0.109156
EZR ezrin 0.108345
CCNE1 cyclin E1 0.107709
HBEGF heparin-binding EGF-like growth factor 0.107443
INHBA inhibin, beta A 0.104776
SDC2 syndecan 2 0.103955
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.103501
GIF gastric intrinsic factor (vitamin B synthesis) 0.102996
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.102319
PGR progesterone receptor 0.101802
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.099104
PPARG peroxisome proliferator-activated receptor gamma 0.09865
AHR aryl hydrocarbon receptor 0.097636
ODC1 ornithine decarboxylase 1 0.096226