choriocarcinoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected. (Experimental Factor Ontology, EFO_0002893)
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Genes

62 genes co-occuring with the biological term choriocarcinoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ANG angiogenin, ribonuclease, RNase A family, 5
ASCL2 achaete-scute family bHLH transcription factor 2
BCL9L B-cell CLL/lymphoma 9-like
BDNF brain-derived neurotrophic factor
CGB chorionic gonadotropin, beta polypeptide
CGB5 chorionic gonadotropin, beta polypeptide 5
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DIO2 deiodinase, iodothyronine, type II
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLL1 delta-like 1 (Drosophila)
EPHA1 EPH receptor A1
EPHA4 EPH receptor A4
ERVW-1 endogenous retrovirus group W, member 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBXW8 F-box and WD repeat domain containing 8
GCM1 glial cells missing homolog 1 (Drosophila)
GH1 growth hormone 1
GH2 growth hormone 2
GKN1 gastrokine 1
HLA-G major histocompatibility complex, class I, G
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IL11 interleukin 11
IL17A interleukin 17A
INSR insulin receptor
JAK2 Janus kinase 2
LCN2 lipocalin 2
LEP leptin
LEPQTL1 Leptin, serum levels of
LNPEP leucyl/cystinyl aminopeptidase
MAPK14 mitogen-activated protein kinase 14
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MIR199B microRNA 199b
MIR34A microRNA 34a
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NR6A1 nuclear receptor subfamily 6, group A, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PGR progesterone receptor
PLIN2 perilipin 2
PPARG peroxisome proliferator-activated receptor gamma
PTEN phosphatase and tensin homolog
RORA RAR-related orphan receptor A
RXRA retinoid X receptor, alpha
SET SET nuclear proto-oncogene
SMAD3 SMAD family member 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMED2 transmembrane emp24 domain trafficking protein 2
TP53 tumor protein p53
TP63 tumor protein p63
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNT5A wingless-type MMTV integration site family, member 5A