cicloheximide-5743 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the cicloheximide-5743 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ANGPTL4 angiopoietin-like 4
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL14 ADP-ribosylation factor-like 14
ATF3 activating transcription factor 3
BDNF brain-derived neurotrophic factor
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDN1 claudin 1
COL4A6 collagen, type IV, alpha 6
CREB5 cAMP responsive element binding protein 5
CTGF connective tissue growth factor
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DIO2 deiodinase, iodothyronine, type II
DLX2 distal-less homeobox 2
DMBT1 deleted in malignant brain tumors 1
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EGR2 early growth response 2
ELL2 elongation factor, RNA polymerase II, 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FCMR Fc fragment of IgM receptor
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
H1FX H1 histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2AG histone cluster 1, H2ag
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BJ histone cluster 1, H2bj
HIST1H3B histone cluster 1, H3b
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL11 interleukin 11
IL1A interleukin 1, alpha
IL24 interleukin 24
IL6 interleukin 6
INHBA inhibin, beta A
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
OASL 2'-5'-oligoadenylate synthetase-like
PDE4B phosphodiesterase 4B, cAMP-specific
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RND1 Rho family GTPase 1
S1PR1 sphingosine-1-phosphate receptor 1
SAMD4A sterile alpha motif domain containing 4A
SGK1 serum/glucocorticoid regulated kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNAI2 snail family zinc finger 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
STC2 stanniocalcin 2
STK17B serine/threonine kinase 17b
SYNE1 spectrin repeat containing, nuclear envelope 1
TBX3 T-box 3
TGFB2 transforming growth factor, beta 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ALAS1 5'-aminolevulinate synthase 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKRD36 ankyrin repeat domain 36
ANKRD36B ankyrin repeat domain 36B
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ASB13 ankyrin repeat and SOCS box containing 13
AXIN1 axin 1
BAG3 BCL2-associated athanogene 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CBR3 carbonyl reductase 3
CCDC25 coiled-coil domain containing 25
CCNE2 cyclin E2
CDADC1 cytidine and dCMP deaminase domain containing 1
CERK ceramide kinase
CGREF1 cell growth regulator with EF-hand domain 1
CHRM3 cholinergic receptor, muscarinic 3
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CSK c-src tyrosine kinase
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DTX4 deltex 4, E3 ubiquitin ligase
EFNA4 ephrin-A4
EHBP1L1 EH domain binding protein 1-like 1
EHD3 EH-domain containing 3
EPHB6 EPH receptor B6
FAM102A family with sequence similarity 102, member A
FAM172A family with sequence similarity 172, member A
FBXL4 F-box and leucine-rich repeat protein 4
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FZD3 frizzled class receptor 3
FZD4 frizzled class receptor 4
GLCE glucuronic acid epimerase
GPR137B G protein-coupled receptor 137B
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
HDAC4 histone deacetylase 4
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HILPDA hypoxia inducible lipid droplet-associated
HIRA histone cell cycle regulator
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
IGSF3 immunoglobulin superfamily, member 3
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL4R interleukin 4 receptor
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITPKB inositol-trisphosphate 3-kinase B
KCTD15 potassium channel tetramerization domain containing 15
KLF11 Kruppel-like factor 11
KLHL3 kelch-like family member 3
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMNB1 lamin B1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRRC37A3 leucine rich repeat containing 37, member A3
MFSD11 major facilitator superfamily domain containing 11
MKNK2 MAP kinase interacting serine/threonine kinase 2
MXD3 MAX dimerization protein 3
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAIP NLR family, apoptosis inhibitory protein
NINL ninein-like
OLFML2A olfactomedin-like 2A
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PANX1 pannexin 1
PDZD2 PDZ domain containing 2
PHLDA3 pleckstrin homology-like domain, family A, member 3
PHTF1 putative homeodomain transcription factor 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAB3A RAB3A, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RNASE4 ribonuclease, RNase A family, 4
SALL2 spalt-like transcription factor 2
SCAMP5 secretory carrier membrane protein 5
SESN1 sestrin 1
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SKI SKI proto-oncogene
SLC25A40 solute carrier family 25, member 40
SNPH syntaphilin
SOX12 SRY (sex determining region Y)-box 12
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STARD7 StAR-related lipid transfer (START) domain containing 7
TBC1D16 TBC1 domain family, member 16
TESK2 testis-specific kinase 2
TMCC2 transmembrane and coiled-coil domain family 2
TMEM57 transmembrane protein 57
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRAK2 trafficking protein, kinesin binding 2
TRIB2 tribbles pseudokinase 2
TSPAN12 tetraspanin 12
USP18 ubiquitin specific peptidase 18
VASH2 vasohibin 2
ZNF668 zinc finger protein 668