ciclopirox-5023 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ciclopirox-5023 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ATF3 activating transcription factor 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAX BCL2-associated X protein
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DPYSL4 dihydropyrimidinase-like 4
EFNA3 ephrin-A3
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ENO2 enolase 2 (gamma, neuronal)
ERO1L ERO1-like (S. cerevisiae)
FAM212B family with sequence similarity 212, member B
FAM57A family with sequence similarity 57, member A
FAS Fas cell surface death receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
GPR87 G protein-coupled receptor 87
HBEGF heparin-binding EGF-like growth factor
HILPDA hypoxia inducible lipid droplet-associated
HIPK3 homeodomain interacting protein kinase 3
HK2 hexokinase 2
IGFBP3 insulin-like growth factor binding protein 3
ING1 inhibitor of growth family, member 1
INSIG2 insulin induced gene 2
IPW imprinted in Prader-Willi syndrome (non-protein coding)
KDM3A lysine (K)-specific demethylase 3A
KRT16 keratin 16, type I
LIF leukemia inhibitory factor
LIMK2 LIM domain kinase 2
LOXL2 lysyl oxidase-like 2
LY6D lymphocyte antigen 6 complex, locus D
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUPR1 nuclear protein, transcriptional regulator, 1
OVOL1 ovo-like zinc finger 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGM1 phosphoglucomutase 1
PHF20 PHD finger protein 20
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLAUR plasminogen activator, urokinase receptor
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLK3 polo-like kinase 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PNRC1 proline-rich nuclear receptor coactivator 1
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PSPH phosphoserine phosphatase
PVT1 Pvt1 oncogene (non-protein coding)
RGS20 regulator of G-protein signaling 20
RNF19B ring finger protein 19B
RPL35A ribosomal protein L35a
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SCAND2P SCAN domain containing 2 pseudogene
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SFXN3 sideroflexin 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG4 sperm associated antigen 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC1 stanniocalcin 1
TCP11L1 t-complex 11, testis-specific-like 1
TMEM45A transmembrane protein 45A
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ARHGAP11A Rho GTPase activating protein 11A
ARL4A ADP-ribosylation factor-like 4A
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
BAHCC1 BAH domain and coiled-coil containing 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BORA bora, aurora kinase A activator
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C11ORF63 chromosome 11 open reading frame 63
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCNB1 cyclin B1
CCNF cyclin F
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
CNGB3 cyclic nucleotide gated channel beta 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
DBF4 DBF4 zinc finger
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECHDC3 enoyl CoA hydratase domain containing 3
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERCC6L excision repair cross-complementation group 6-like
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FAM64A family with sequence similarity 64, member A
FZD2 frizzled class receptor 2
GAB2 GRB2-associated binding protein 2
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPATCH3 G patch domain containing 3
H1F0 H1 histone family, member 0
H2AFJ H2A histone family, member J
HIST1H1D histone cluster 1, H1d
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC13 homeobox C13
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
IFI27 interferon, alpha-inducible protein 27
IFT22 intraflagellar transport 22
KIAA1551 KIAA1551
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KLHL28 kelch-like family member 28
MEIS1 Meis homeobox 1
MYLIP myosin regulatory light chain interacting protein
MYO9A myosin IXA
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OVOL2 ovo-like zinc finger 2
PACS1 phosphofurin acidic cluster sorting protein 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITX2 paired-like homeodomain 2
PLA2G3 phospholipase A2, group III
PLK1 polo-like kinase 1
POMT2 protein-O-mannosyltransferase 2
PRC1 protein regulator of cytokinesis 1
PSRC1 proline/serine-rich coiled-coil 1
PVRL3 poliovirus receptor-related 3
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFTN1 raftlin, lipid raft linker 1
RNF122 ring finger protein 122
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLIT2 slit homolog 2 (Drosophila)
SMTN smoothelin
STIM1 stromal interaction molecule 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TEX40 testis expressed 40
THBS3 thrombospondin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRABD TraB domain containing
TRAF2 TNF receptor-associated factor 2
TROAP trophinin associated protein
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBQLN4 ubiquilin 4
USP27X ubiquitin specific peptidase 27, X-linked
ZBTB48 zinc finger and BTB domain containing 48
ZC3H3 zinc finger CCCH-type containing 3
ZNF165 zinc finger protein 165
ZNF329 zinc finger protein 329
ZNF350 zinc finger protein 350