cimetidine-1884 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the cimetidine-1884 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIM1L absent in melanoma 1-like
ALAD aminolevulinate dehydratase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOE apolipoprotein E
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BIRC7 baculoviral IAP repeat containing 7
C9ORF9 chromosome 9 open reading frame 9
CACFD1 calcium channel flower domain containing 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CALB2 calbindin 2
CAMKV CaM kinase-like vesicle-associated
CD2BP2 CD2 (cytoplasmic tail) binding protein 2
CHN2 chimerin 2
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLTA clathrin, light chain A
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNTFR ciliary neurotrophic factor receptor
CORT cortistatin
CPM carboxypeptidase M
CPNE7 copine VII
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAZAP1 DAZ associated protein 1
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DUSP26 dual specificity phosphatase 26 (putative)
EIF1 eukaryotic translation initiation factor 1
FGFR1 fibroblast growth factor receptor 1
FLJ42627 uncharacterized LOC645644
FSCN1 fascin actin-bundling protein 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAL galanin/GMAP prepropeptide
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNL1 guanine nucleotide binding protein-like 1
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IGHA1 immunoglobulin heavy constant alpha 1
IL2RG interleukin 2 receptor, gamma
IQCC IQ motif containing C
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIF1C kinesin family member 1C
KIF25 kinesin family member 25
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LAMA2 laminin, alpha 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMS2 LIM and senescent cell antigen-like domains 2
LLGL1 lethal giant larvae homolog 1 (Drosophila)
METTL7A methyltransferase like 7A
MIIP migration and invasion inhibitory protein
MRC2 mannose receptor, C type 2
MTF1 metal-regulatory transcription factor 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYT1 myelin transcription factor 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NIPAL2 NIPA-like domain containing 2
NPEPL1 aminopeptidase-like 1
NPPA natriuretic peptide A
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLCG1 phospholipase C, gamma 1
PLD2 phospholipase D2
PNMT phenylethanolamine N-methyltransferase
PPARA peroxisome proliferator-activated receptor alpha
PRB1 proline-rich protein BstNI subfamily 1
PRB3 proline-rich protein BstNI subfamily 3
PRLH prolactin releasing hormone
PTGES2 prostaglandin E synthase 2
RAB2A RAB2A, member RAS oncogene family
RANBP3 RAN binding protein 3
REM1 RAS (RAD and GEM)-like GTP-binding 1
RPL7 ribosomal protein L7
RRAD Ras-related associated with diabetes
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFTPC surfactant protein C
SH2B1 SH2B adaptor protein 1
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SPDEF SAM pointed domain containing ETS transcription factor
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SPN sialophorin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TRIM29 tripartite motif containing 29
TUBA4B tubulin, alpha 4b
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBQLN4 ubiquilin 4
UBTD1 ubiquitin domain containing 1
UNC45A unc-45 homolog A (C. elegans)
USF2 upstream transcription factor 2, c-fos interacting
VGF VGF nerve growth factor inducible
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZC3H7B zinc finger CCCH-type containing 7B
ZDHHC11 zinc finger, DHHC-type containing 11
ZFHX2 zinc finger homeobox 2

decreased expression

Symbol Name
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1C3 aldo-keto reductase family 1, member C3
ARHGAP17 Rho GTPase activating protein 17
ASCC1 activating signal cointegrator 1 complex subunit 1
BCL7C B-cell CLL/lymphoma 7C
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C10ORF2 chromosome 10 open reading frame 2
C1ORF115 chromosome 1 open reading frame 115
C1ORF27 chromosome 1 open reading frame 27
CAPNS1 calpain, small subunit 1
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CDA cytidine deaminase
CDCA8 cell division cycle associated 8
CEP85 centrosomal protein 85kDa
CFD complement factor D (adipsin)
CLK2 CDC-like kinase 2
COMMD9 COMM domain containing 9
DAP death-associated protein
ECH1 enoyl CoA hydratase 1, peroxisomal
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EMC9 ER membrane protein complex subunit 9
ENO2 enolase 2 (gamma, neuronal)
ERCC2 excision repair cross-complementation group 2
FKBPL FK506 binding protein like
FUCA1 fucosidase, alpha-L- 1, tissue
GALNS galactosamine (N-acetyl)-6-sulfatase
GALR3 galanin receptor 3
GBAP1 glucosidase, beta, acid pseudogene 1
GLOD4 glyoxalase domain containing 4
GOLGA3 golgin A3
GOLPH3L golgi phosphoprotein 3-like
GPS2 G protein pathway suppressor 2
HARS histidyl-tRNA synthetase
HIST1H2BF histone cluster 1, H2bf
IGFBP6 insulin-like growth factor binding protein 6
ITFG1 integrin alpha FG-GAP repeat containing 1
JMJD4 jumonji domain containing 4
KEAP1 kelch-like ECH-associated protein 1
KIF1B kinesin family member 1B
KRT34 keratin 34, type I
LIG1 ligase I, DNA, ATP-dependent
LSR lipolysis stimulated lipoprotein receptor
LY6E lymphocyte antigen 6 complex, locus E
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPKBP1 mitogen-activated protein kinase binding protein 1
MARC1 mitochondrial amidoxime reducing component 1
MGMT O-6-methylguanine-DNA methyltransferase
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MRPL16 mitochondrial ribosomal protein L16
MSRB1 methionine sulfoxide reductase B1
MT1HL1 metallothionein 1H-like 1
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NCAPH non-SMC condensin I complex, subunit H
NOD1 nucleotide-binding oligomerization domain containing 1
NVL nuclear VCP-like
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OGFRL1 opioid growth factor receptor-like 1
ORC3 origin recognition complex, subunit 3
P3H2 prolyl 3-hydroxylase 2
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALB2 partner and localizer of BRCA2
PCTP phosphatidylcholine transfer protein
PKN1 protein kinase N1
PLTP phospholipid transfer protein
POGK pogo transposable element with KRAB domain
POR P450 (cytochrome) oxidoreductase
POU2F1 POU class 2 homeobox 1
PPT2 palmitoyl-protein thioesterase 2
PYGB phosphorylase, glycogen; brain
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM10 RNA binding motif protein 10
RECQL4 RecQ protein-like 4
RNF220 ring finger protein 220
RPUSD2 RNA pseudouridylate synthase domain containing 2
SCNM1 sodium channel modifier 1
SCO2 SCO2 cytochrome c oxidase assembly protein
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMYD5 SMYD family member 5
SNF8 SNF8, ESCRT-II complex subunit
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM104 transmembrane protein 104
TMEM51 transmembrane protein 51
TRAPPC12 trafficking protein particle complex 12
TRIM58 tripartite motif containing 58
TSSC4 tumor suppressing subtransferable candidate 4
TTC23 tetratricopeptide repeat domain 23
UGDH UDP-glucose 6-dehydrogenase
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
WDR6 WD repeat domain 6
ZC3H3 zinc finger CCCH-type containing 3
ZNF532 zinc finger protein 532