cinchocaine Gene Set

Dataset	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category	transcriptomics
Type	small molecule perturbation
Description	A monocarboxylic acid amide that is the 2-(diethylamino)ethyl amide of 2-butoxyquinoline-4-carboxylic acid. One of the most potent and toxic of the long-acting local anesthetics, its parenteral use was restricted to spinal anesthesia. It is now generally only used (usually as the hydrochloride) in creams and ointments and in suppositories for temporary relief of pain and itching associated with skin and anorectal conditions. (Chemical Entities of Biological Interest Ontology, CHEBI_247956)
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Genes

16 genes differentially expressed following the cinchocaine small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol	Name	Standardized Value
E2F2	E2F transcription factor 2	4.35679
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	3.63035
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	3.45139
RASA1	RAS p21 protein activator (GTPase activating protein) 1	3.42697
SLC5A6	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	3.39688
PCYT1A	phosphate cytidylyltransferase 1, choline, alpha	3.34229

decreased expression

Symbol	Name	Standardized Value
CANT1	calcium activated nucleotidase 1	-5.16524
NPEPL1	aminopeptidase-like 1	-3.97978
ZFHX2	zinc finger homeobox 2	-3.97916
DPH5	diphthamide biosynthesis 5	-3.57974
ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)	-3.55723
DFFB	DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)	-3.23198
KIF1A	kinesin family member 1A	-3.18524
CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	-3.1141
BPHL	biphenyl hydrolase-like (serine hydrolase)	-3.07866
HTATIP2	HIV-1 Tat interactive protein 2, 30kDa	-3.06247