cinnarizine-5817 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the cinnarizine-5817 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADA adenosine deaminase
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
AQP7 aquaporin 7
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ASTN2 astrotactin 2
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
AVPR1B arginine vasopressin receptor 1B
BEND5 BEN domain containing 5
BRAP BRCA1 associated protein
BTN3A2 butyrophilin, subfamily 3, member A2
CASR calcium-sensing receptor
CCL11 chemokine (C-C motif) ligand 11
CD300C CD300c molecule
CDC14B cell division cycle 14B
CDON cell adhesion associated, oncogene regulated
CEP162 centrosomal protein 162kDa
COPE coatomer protein complex, subunit epsilon
CTNS cystinosin, lysosomal cystine transporter
CYHR1 cysteine/histidine-rich 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DOCK6 dedicator of cytokinesis 6
EGR2 early growth response 2
EHBP1L1 EH domain binding protein 1-like 1
EPB41L1 erythrocyte membrane protein band 4.1-like 1
ESR1 estrogen receptor 1
ETV1 ets variant 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FYB FYN binding protein
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GLYAT glycine-N-acyltransferase
HAUS5 HAUS augmin-like complex, subunit 5
HDAC9 histone deacetylase 9
HOXA4 homeobox A4
IGHM immunoglobulin heavy constant mu
IL27RA interleukin 27 receptor, alpha
INO80B INO80 complex subunit B
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KIF1A kinesin family member 1A
KRT75 keratin 75, type II
KRT86 keratin 86, type II
LPAR4 lysophosphatidic acid receptor 4
LRRC8B leucine rich repeat containing 8 family, member B
LRRTM2 leucine rich repeat transmembrane neuronal 2
LTBP4 latent transforming growth factor beta binding protein 4
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MKRN3 makorin ring finger protein 3
MUC3A mucin 3A, cell surface associated
MYH14 myosin, heavy chain 14, non-muscle
NAV3 neuron navigator 3
ODF2 outer dense fiber of sperm tails 2
ORAI2 ORAI calcium release-activated calcium modulator 2
OSGIN1 oxidative stress induced growth inhibitor 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAIP2B poly(A) binding protein interacting protein 2B
PALMD palmdelphin
PGAP1 post-GPI attachment to proteins 1
PKP3 plakophilin 3
PLXND1 plexin D1
POM121L2 POM121 transmembrane nucleoporin-like 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROL1 proline rich, lacrimal 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RWDD2A RWD domain containing 2A
SBNO2 strawberry notch homolog 2 (Drosophila)
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SEPHS1 selenophosphate synthetase 1
SKIL SKI-like proto-oncogene
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMC1A structural maintenance of chromosomes 1A
SNRPN small nuclear ribonucleoprotein polypeptide N
SOS1 son of sevenless homolog 1 (Drosophila)
STAT2 signal transducer and activator of transcription 2, 113kDa
SULF1 sulfatase 1
SUSD5 sushi domain containing 5
SVIL supervillin
SYCP2 synaptonemal complex protein 2
TMEM120B transmembrane protein 120B
TOX4 TOX high mobility group box family member 4
TRAF3IP2 TRAF3 interacting protein 2
TREX1 three prime repair exonuclease 1
TRIM2 tripartite motif containing 2
TSNAXIP1 translin-associated factor X interacting protein 1
ZBTB7A zinc finger and BTB domain containing 7A
ZNF24 zinc finger protein 24
ZNF277 zinc finger protein 277
ZNF778 zinc finger protein 778
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ALS2CL ALS2 C-terminal like
ANG angiogenin, ribonuclease, RNase A family, 5
ANKRD40 ankyrin repeat domain 40
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANXA10 annexin A10
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP13A2 ATPase type 13A2
BAG4 BCL2-associated athanogene 4
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BRAF B-Raf proto-oncogene, serine/threonine kinase
C11ORF63 chromosome 11 open reading frame 63
C16ORF59 chromosome 16 open reading frame 59
CASZ1 castor zinc finger 1
CDADC1 cytidine and dCMP deaminase domain containing 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRM3 cholinergic receptor, muscarinic 3
CISH cytokine inducible SH2-containing protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CXCL3 chemokine (C-X-C motif) ligand 3
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DNAL4 dynein, axonemal, light chain 4
EDC3 enhancer of mRNA decapping 3
EMC6 ER membrane protein complex subunit 6
FAM131A family with sequence similarity 131, member A
FBXL6 F-box and leucine-rich repeat protein 6
FKBPL FK506 binding protein like
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
H2AFY2 H2A histone family, member Y2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMOX1 heme oxygenase 1
IFT54 intraflagellar transport 54
INPPL1 inositol polyphosphate phosphatase-like 1
KCTD7 potassium channel tetramerization domain containing 7
KDM5C lysine (K)-specific demethylase 5C
KIAA0922 KIAA0922
KIF3A kinesin family member 3A
KIRREL kin of IRRE like (Drosophila)
KLHL3 kelch-like family member 3
LOC100127972 uncharacterized LOC100127972
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC730101 uncharacterized LOC730101
LONRF3 LON peptidase N-terminal domain and ring finger 3
LPAR6 lysophosphatidic acid receptor 6
LYPLA2P1 lysophospholipase II pseudogene 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAP1S microtubule-associated protein 1S
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MEIS1 Meis homeobox 1
MPP1 membrane protein, palmitoylated 1, 55kDa
MXRA8 matrix-remodelling associated 8
NADSYN1 NAD synthetase 1
NDE1 nudE neurodevelopment protein 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOTCH1 notch 1
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
NXPE3 neurexophilin and PC-esterase domain family, member 3
OLFML2A olfactomedin-like 2A
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PACS1 phosphofurin acidic cluster sorting protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PORCN porcupine homolog (Drosophila)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR15L proline rich 15-like
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RAB5B RAB5B, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RNF220 ring finger protein 220
RPAP1 RNA polymerase II associated protein 1
RPUSD2 RNA pseudouridylate synthase domain containing 2
SCAMP5 secretory carrier membrane protein 5
SCN1B sodium channel, voltage gated, type I beta subunit
SDC3 syndecan 3
SDF2 stromal cell-derived factor 2
SETBP1 SET binding protein 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SIX1 SIX homeobox 1
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC35G2 solute carrier family 35, member G2
SOBP sine oculis binding protein homolog (Drosophila)
SP140L SP140 nuclear body protein-like
SPAG4 sperm associated antigen 4
STAG3 stromal antigen 3
STEAP4 STEAP family member 4
SUOX sulfite oxidase
TGFB3 transforming growth factor, beta 3
THAP7 THAP domain containing 7
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TOLLIP toll interacting protein
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
USP27X ubiquitin specific peptidase 27, X-linked
VASH2 vasohibin 2
YIPF1 Yip1 domain family, member 1
ZBTB3 zinc finger and BTB domain containing 3
ZNF197 zinc finger protein 197
ZNF747 zinc finger protein 747
ZNF84 zinc finger protein 84