cinoxacin-2722 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the cinoxacin-2722 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTN2 actinin, alpha 2
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADGRB1 adhesion G protein-coupled receptor B1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALX3 ALX homeobox 3
BICC1 BicC family RNA binding protein 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CD59 CD59 molecule, complement regulatory protein
CDO1 cysteine dioxygenase type 1
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLDN9 claudin 9
CLTA clathrin, light chain A
COL13A1 collagen, type XIII, alpha 1
COL6A1 collagen, type VI, alpha 1
CRMP1 collapsin response mediator protein 1
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CUX2 cut-like homeobox 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDR1 discoidin domain receptor tyrosine kinase 1
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DRD2 dopamine receptor D2
DZIP3 DAZ interacting zinc finger protein 3
EDNRA endothelin receptor type A
EXTL3 exostosin-like glycosyltransferase 3
FAM105A family with sequence similarity 105, member A
FCAR Fc fragment of IgA receptor
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FLRT1 fibronectin leucine rich transmembrane protein 1
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HNF4A hepatocyte nuclear factor 4, alpha
HOXC4 homeobox C4
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFT27 intraflagellar transport 27
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL3RA interleukin 3 receptor, alpha (low affinity)
IRF4 interferon regulatory factor 4
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KLHL3 kelch-like family member 3
LAMP1 lysosomal-associated membrane protein 1
LYZL6 lysozyme-like 6
LZTS1 leucine zipper, putative tumor suppressor 1
MAGEA6 melanoma antigen family A6
MEGF6 multiple EGF-like-domains 6
MFSD6 major facilitator superfamily domain containing 6
MLXIPL MLX interacting protein-like
MMP11 matrix metallopeptidase 11
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MRPS12 mitochondrial ribosomal protein S12
MYO1E myosin IE
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPTX2 neuronal pentraxin II
NYNRIN NYN domain and retroviral integrase containing
OMG oligodendrocyte myelin glycoprotein
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCSK6 proprotein convertase subtilisin/kexin type 6
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIWIL1 piwi-like RNA-mediated gene silencing 1
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
POFUT2 protein O-fucosyltransferase 2
POMT2 protein-O-mannosyltransferase 2
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB40B RAB40B, member RAS oncogene family
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBP3 retinol binding protein 3, interstitial
RCAN2 regulator of calcineurin 2
RHOD ras homolog family member D
RNF25 ring finger protein 25
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
SCARB1 scavenger receptor class B, member 1
SDS serine dehydratase
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SPATA6 spermatogenesis associated 6
SPDEF SAM pointed domain containing ETS transcription factor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRSF7 serine/arginine-rich splicing factor 7
SSX7 synovial sarcoma, X breakpoint 7
STOML1 stomatin (EPB72)-like 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBX2 T-box 2
TSPAN9 tetraspanin 9
VPS9D1 VPS9 domain containing 1
ZNF154 zinc finger protein 154

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ADM adrenomedullin
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMDHD2 amidohydrolase domain containing 2
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARRB1 arrestin, beta 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BBC3 BCL2 binding component 3
BTF3P12 basic transcription factor 3 pseudogene 12
C14ORF93 chromosome 14 open reading frame 93
C19ORF40 chromosome 19 open reading frame 40
C5ORF45 chromosome 5 open reading frame 45
CA11 carbonic anhydrase XI
CAMKMT calmodulin-lysine N-methyltransferase
CD70 CD70 molecule
CD9 CD9 molecule
CDA cytidine deaminase
CENPJ centromere protein J
CHM choroideremia (Rab escort protein 1)
CLDND1 claudin domain containing 1
CSNK1G3 casein kinase 1, gamma 3
DENND2D DENN/MADD domain containing 2D
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETAA1 Ewing tumor-associated antigen 1
EXOC5 exocyst complex component 5
FAM204A family with sequence similarity 204, member A
FEM1C fem-1 homolog c (C. elegans)
FKBP5 FK506 binding protein 5
FUZ fuzzy planar cell polarity protein
GBP2 guanylate binding protein 2, interferon-inducible
GPHN gephyrin
GPR183 G protein-coupled receptor 183
GPRC5C G protein-coupled receptor, class C, group 5, member C
GTF2I general transcription factor IIi
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HS1BP3 HCLS1 binding protein 3
IFT81 intraflagellar transport 81
IGFLR1 IGF-like family receptor 1
IPO8 importin 8
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCTD20 potassium channel tetramerization domain containing 20
KCTD7 potassium channel tetramerization domain containing 7
KLF3 Kruppel-like factor 3 (basic)
LIG4 ligase IV, DNA, ATP-dependent
LINC00115 long intergenic non-protein coding RNA 115
LMAN1 lectin, mannose-binding, 1
LRRK1 leucine-rich repeat kinase 1
LTC4S leukotriene C4 synthase
MAGEF1 melanoma antigen family F1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED15 mediator complex subunit 15
NAG18 NAG18 mRNA
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PADI2 peptidyl arginine deiminase, type II
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PEX26 peroxisomal biogenesis factor 26
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKCZ protein kinase C, zeta
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB33B RAB33B, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RFXAP regulatory factor X-associated protein
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SCRN3 secernin 3
SCYL2 SCY1-like 2 (S. cerevisiae)
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SETD1A SET domain containing 1A
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SP140L SP140 nuclear body protein-like
SPAG4 sperm associated antigen 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAT5A signal transducer and activator of transcription 5A
TMC5 transmembrane channel-like 5
TMEM230 transmembrane protein 230
TMEM53 transmembrane protein 53
TWSG1 twisted gastrulation BMP signaling modulator 1
UEVLD UEV and lactate/malate dehyrogenase domains
UPB1 ureidopropionase, beta
UPK3A uroplakin 3A
YY2 YY2 transcription factor
ZNF492 zinc finger protein 492
ZNF862 zinc finger protein 862
ZW10 zw10 kinetochore protein