ciprofloxacin-6700 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the ciprofloxacin-6700 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM11 ADAM metallopeptidase domain 11
AIM2 absent in melanoma 2
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
ATN1 atrophin 1
ATP10A ATPase, class V, type 10A
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BGN biglycan
C3 complement component 3
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALB2 calbindin 2
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CD79B CD79b molecule, immunoglobulin-associated beta
CDRT1 CMT1A duplicated region transcript 1
CHMP6 charged multivesicular body protein 6
CISH cytokine inducible SH2-containing protein
CLCN4 chloride channel, voltage-sensitive 4
COL9A2 collagen, type IX, alpha 2
CPN2 carboxypeptidase N, polypeptide 2
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CXCR6 chemokine (C-X-C motif) receptor 6
DCLK2 doublecortin-like kinase 2
DGCR8 DGCR8 microprocessor complex subunit
DIAPH2 diaphanous-related formin 2
DTNB dystrobrevin, beta
EDA ectodysplasin A
EDIL3 EGF-like repeats and discoidin I-like domains 3
EDN1 endothelin 1
EGR4 early growth response 4
ESR1 estrogen receptor 1
FAM65B family with sequence similarity 65, member B
FBXO2 F-box protein 2
FGF6 fibroblast growth factor 6
FOXL1 forkhead box L1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GK glycerol kinase
GPR22 G protein-coupled receptor 22
GRIA3 glutamate receptor, ionotropic, AMPA 3
H2AFX H2A histone family, member X
HAPLN1 hyaluronan and proteoglycan link protein 1
HBP1 HMG-box transcription factor 1
HEATR6 HEAT repeat containing 6
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
IHH indian hedgehog
IL1RN interleukin 1 receptor antagonist
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LIMD1 LIM domains containing 1
LIPG lipase, endothelial
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMCD1 LIM and cysteine-rich domains 1
LOC79999 uncharacterized LOC79999
LRP2 low density lipoprotein receptor-related protein 2
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
MAPK14 mitogen-activated protein kinase 14
MFAP3L microfibrillar-associated protein 3-like
MILR1 mast cell immunoglobulin-like receptor 1
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MMP3 matrix metallopeptidase 3
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NPIPB3 nuclear pore complex interacting protein family, member B3
OR2B6 olfactory receptor, family 2, subfamily B, member 6
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PADI1 peptidyl arginine deiminase, type I
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP prolactin-induced protein
PKNOX1 PBX/knotted 1 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PRKCA protein kinase C, alpha
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RBFA ribosome binding factor A (putative)
RNGTT RNA guanylyltransferase and 5'-phosphatase
RUFY3 RUN and FYVE domain containing 3
SAMD4B sterile alpha motif domain containing 4B
SCAPER S-phase cyclin A-associated protein in the ER
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEPP1 selenoprotein P, plasma, 1
SMAD6 SMAD family member 6
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
TAT tyrosine aminotransferase
TGFB1 transforming growth factor, beta 1
TM4SF4 transmembrane 4 L six family member 4
TMPRSS2 transmembrane protease, serine 2
TNK2 tyrosine kinase, non-receptor, 2
TSKS testis-specific serine kinase substrate
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YTHDC2 YTH domain containing 2
ZFP64 ZFP64 zinc finger protein
ZNF589 zinc finger protein 589
ZNF695 zinc finger protein 695
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADCY7 adenylate cyclase 7
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAHD1 bromo adjacent homology domain containing 1
BEX1 brain expressed, X-linked 1
C14ORF105 chromosome 14 open reading frame 105
C17ORF70 chromosome 17 open reading frame 70
C1ORF54 chromosome 1 open reading frame 54
CASP5 caspase 5, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CCDC130 coiled-coil domain containing 130
CD79A CD79a molecule, immunoglobulin-associated alpha
CEL carboxyl ester lipase
CLEC16A C-type lectin domain family 16, member A
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CORO2A coronin, actin binding protein, 2A
CTC1 CTS telomere maintenance complex component 1
CYB5R2 cytochrome b5 reductase 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
EMD emerin
FA2H fatty acid 2-hydroxylase
FAM186A family with sequence similarity 186, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FKBP10 FK506 binding protein 10, 65 kDa
GRAMD1C GRAM domain containing 1C
GSTA3 glutathione S-transferase alpha 3
H2AFJ H2A histone family, member J
HIRA histone cell cycle regulator
HIST1H3I histone cluster 1, H3i
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMHA1 histocompatibility (minor) HA-1
HOOK1 hook microtubule-tethering protein 1
IFI6 interferon, alpha-inducible protein 6
IL2 interleukin 2
IREB2 iron-responsive element binding protein 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM8 lysine (K)-specific demethylase 8
KPTN kaptin (actin binding protein)
KRT9 keratin 9, type I
LINC00472 long intergenic non-protein coding RNA 472
LRRC61 leucine rich repeat containing 61
MAGEH1 melanoma antigen family H1
MAPK12 mitogen-activated protein kinase 12
MOCS1 molybdenum cofactor synthesis 1
MON1B MON1 secretory trafficking family member B
MUC3A mucin 3A, cell surface associated
MUC3B mucin 3B, cell surface associated
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NID2 nidogen 2 (osteonidogen)
NOTCH1 notch 1
NSUN6 NOP2/Sun domain family, member 6
NXPH4 neurexophilin 4
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
PAIP2B poly(A) binding protein interacting protein 2B
PALM paralemmin
PARM1 prostate androgen-regulated mucin-like protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PODXL2 podocalyxin-like 2
PRR7 proline rich 7 (synaptic)
PXDC1 PX domain containing 1
RAI2 retinoic acid induced 2
RAPSN receptor-associated protein of the synapse
RHOBTB1 Rho-related BTB domain containing 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
ROM1 retinal outer segment membrane protein 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SPATA2L spermatogenesis associated 2-like
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYNGR3 synaptogyrin 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TESPA1 thymocyte expressed, positive selection associated 1
TMEM212 transmembrane protein 212
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TTLL1 tubulin tyrosine ligase-like family member 1
WDR25 WD repeat domain 25
WNT10B wingless-type MMTV integration site family, member 10B
WNT7A wingless-type MMTV integration site family, member 7A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XYLT2 xylosyltransferase II
ZBTB3 zinc finger and BTB domain containing 3
ZNF222 zinc finger protein 222
ZNF688 zinc finger protein 688
ZNF702P zinc finger protein 702, pseudogene