cisplatin Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. (Chemical Entities of Biological Interest Ontology, CHEBI_27899)
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Genes

328 genes co-occuring with the biological term cisplatin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM17 ADAM metallopeptidase domain 17
ADIRF adipogenesis regulatory factor
AGTR1 angiotensin II receptor, type 1
AIF1 allograft inflammatory factor 1
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKR1C2 aldo-keto reductase family 1, member C2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANXA1 annexin A1
APAF1 apoptotic peptidase activating factor 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID1A AT rich interactive domain 1A (SWI-like)
ARID1B AT rich interactive domain 1B (SWI1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD3A ATPase family, AAA domain containing 3A
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
ATG14 autophagy related 14
ATG5 autophagy related 5
ATM ATM serine/threonine kinase
ATOX1 antioxidant 1 copper chaperone
ATP11B ATPase, class VI, type 11B
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATP7B ATPase, Cu++ transporting, beta polypeptide
ATR ATR serine/threonine kinase
AURKAIP1 aurora kinase A interacting protein 1
AXL AXL receptor tyrosine kinase
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BAG1 BCL2-associated athanogene
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L12 BCL2-like 12 (proline rich)
BCL2L2 BCL2-like 2
BDNF brain-derived neurotrophic factor
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BIRC6 baculoviral IAP repeat containing 6
BIRC7 baculoviral IAP repeat containing 7
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BSG basigin (Ok blood group)
C1QBP complement component 1, q subcomponent binding protein
CACUL1 CDK2-associated, cullin domain 1
CARD8 caspase recruitment domain family, member 8
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB1 cyclin B1
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDA cytidine deaminase
CDC25A cell division cycle 25A
CDC34 cell division cycle 34
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPF centromere protein F, 350/400kDa
CFL1 cofilin 1 (non-muscle)
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK2 checkpoint kinase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCN3 chloride channel, voltage-sensitive 3
CLDN1 claudin 1
CLDN3 claudin 3
CLDN4 claudin 4
CLOCK clock circadian regulator
CLPTM1L CLPTM1-like
COMT catechol-O-methyltransferase
COPS5 COP9 signalosome subunit 5
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTPS2 CTP synthase 2
CUL4A cullin 4A
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DIABLO diablo, IAP-binding mitochondrial protein
DKC1 dyskeratosis congenita 1, dyskerin
DLG3 discs, large homolog 3 (Drosophila)
DNA2 DNA replication helicase/nuclease 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC5 excision repair cross-complementation group 5
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM168A family with sequence similarity 168, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR4 fibroblast growth factor receptor 4
FN1 fibronectin 1
FOXM1 forkhead box M1
GABARAP GABA(A) receptor-associated protein
GCLM glutamate-cysteine ligase, modifier subunit
GLI1 GLI family zinc finger 1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPX3 glutathione peroxidase 3
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HECA headcase homolog (Drosophila)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOTAIR HOX transcript antisense RNA
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTRA1 HtrA serine peptidase 1
HUS1 HUS1 checkpoint homolog (S. pombe)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL6 interleukin 6
KAT5 K(lysine) acetyltransferase 5
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KIAA1524 KIAA1524
KL klotho
KLF4 Kruppel-like factor 4 (gut)
KLK3 kallikrein-related peptidase 3
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT8 keratin 8, type II
LONP1 lon peptidase 1, mitochondrial
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGMT O-6-methylguanine-DNA methyltransferase
MGST1 microsomal glutathione S-transferase 1
MIEN1 migration and invasion enhancer 1
MIR101-1 microRNA 101-1
MIR101-2 microRNA 101-2
MIR1271 microRNA 1271
MIR130A microRNA 130a
MIR141 microRNA 141
MIR152 microRNA 152
MIR155 microRNA 155
MIR16-1 microRNA 16-1
MIR182 microRNA 182
MIR185 microRNA 185
MIR205 microRNA 205
MIR21 microRNA 21
MIR214 microRNA 214
MIR221 microRNA 221
MIR29A microRNA 29a
MIR302A microRNA 302a
MIR302B microRNA 302b
MIR33A microRNA 33a
MIR34A microRNA 34a
MIR383 microRNA 383
MIR489 microRNA 489
MIR503 microRNA 503
MIR885 microRNA 885
MIR98 microRNA 98
MLH1 mutL homolog 1
MMP19 matrix metallopeptidase 19
MSH5 mutS homolog 5
MT1X metallothionein 1X
MT3 metallothionein 3
MTDH metadherin
MVP major vault protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NANOG Nanog homeobox
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFYA nuclear transcription factor Y, alpha
NKX2-1 NK2 homeobox 1
NKX2-8 NK2 homeobox 8
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NUMB numb homolog (Drosophila)
OGG1 8-oxoguanine DNA glycosylase
ORC6 origin recognition complex, subunit 6
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PARP1 poly (ADP-ribose) polymerase 1
PAX2 paired box 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEBP4 phosphatidylethanolamine-binding protein 4
PER1 period circadian clock 1
PER3 period circadian clock 3
PGRMC1 progesterone receptor membrane component 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKM pyruvate kinase, muscle
PLCG1 phospholipase C, gamma 1
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLB polymerase (DNA directed), beta
POLH polymerase (DNA directed), eta
POSTN periostin, osteoblast specific factor
POU2F1 POU class 2 homeobox 1
POU5F1 POU class 5 homeobox 1
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRDX3 peroxiredoxin 3
PRDX6 peroxiredoxin 6
PRKCD protein kinase C, delta
PTAFR platelet-activating factor receptor
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PURA purine-rich element binding protein A
RAD51 RAD51 recombinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM5 RNA binding motif protein 5
REV1 REV1, polymerase (DNA directed)
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RICTOR RPTOR independent companion of MTOR, complex 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SIRT1 sirtuin 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNAI1 snail family zinc finger 1
SOD1 superoxide dismutase 1, soluble
SOX1 SRY (sex determining region Y)-box 1
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SPA17 sperm autoantigenic protein 17
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF2 serine/arginine-rich splicing factor 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK17A serine/threonine kinase 17a
STX6 syntaxin 6
SULF2 sulfatase 2
TBX2 T-box 2
TEK TEK tyrosine kinase, endothelial
TEP1 telomerase-associated protein 1
TERC telomerase RNA component
TERT telomerase reverse transcriptase
TGM2 transglutaminase 2
TIMP2 TIMP metallopeptidase inhibitor 2
TLK1 tousled-like kinase 1
TLN1 talin 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TLX3 T-cell leukemia homeobox 3
TMEM205 transmembrane protein 205
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TP73-AS1 TP73 antisense RNA 1
TPMT thiopurine S-methyltransferase
TRO trophinin
TWIST1 twist family bHLH transcription factor 1
TXN thioredoxin
TXNL1 thioredoxin-like 1
UBE4B ubiquitination factor E4B
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VAMP4 vesicle-associated membrane protein 4
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
WWOX WW domain containing oxidoreductase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1
ZNF143 zinc finger protein 143