cisplatin Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. (Chemical Entities of Biological Interest Ontology, CHEBI_27899)
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Genes

74 proteins co-occuring with the biological term cisplatin in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADD1 adducin 1 (alpha)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
CLDN7 claudin 7
CTBP1 C-terminal binding protein 1
E2F1 E2F transcription factor 1
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
H2AFX H2A histone family, member X
H3F3A H3 histone, family 3A
HIST1H3A histone cluster 1, H3a
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPB1 heat shock 27kDa protein 1
HTRA2 HtrA serine peptidase 2
LGALS3 lectin, galactoside-binding, soluble, 3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOD1 myogenic differentiation 1
NBN nibrin
NFE2L2 nuclear factor, erythroid 2-like 2
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PLSCR1 phospholipid scramblase 1
POLH polymerase (DNA directed), eta
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PRKCD protein kinase C, delta
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
RAD51 RAD51 recombinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPA2 replication protein A2, 32kDa
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMC1A structural maintenance of chromosomes 1A
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
URI1 URI1, prefoldin-like chaperone
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YAP1 Yes-associated protein 1
ZNHIT1 zinc finger, HIT-type containing 1