cladribine Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia. (Chemical Entities of Biological Interest Ontology, CHEBI_567361)
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Genes

5 genes co-occuring with the biological term cladribine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
DCK deoxycytidine kinase
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
TP53 tumor protein p53