classical Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

399 genes co-occuring with the biological term classical in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACKR3 atypical chemokine receptor 3
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADM adrenomedullin
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRBK2 adrenergic, beta, receptor kinase 2
AGA aspartylglucosaminidase
AGTR1 angiotensin II receptor, type 1
AIF1 allograft inflammatory factor 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA1 annexin A1
AP2M1 adaptor-related protein complex 2, mu 1 subunit
APAF1 apoptotic peptidase activating factor 1
APCS amyloid P component, serum
APOC2 apolipoprotein C-II
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAG1 BCL2-associated athanogene
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C1QC complement component 1, q subcomponent, C chain
C1QTNF3 C1q and tumor necrosis factor related protein 3
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C2 complement component 2
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
C5 complement component 5
C5AR1 complement component 5a receptor 1
CALHM1 calcium homeostasis modulator 1
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CAMP cathelicidin antimicrobial peptide
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCKBR cholecystokinin B receptor
CCL17 chemokine (C-C motif) ligand 17
CCNB1 cyclin B1
CCND1 cyclin D1
CCNE1 cyclin E1
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD163 CD163 molecule
CD209 CD209 molecule
CD28 CD28 molecule
CD34 CD34 molecule
CD40LG CD40 ligand
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD68 CD68 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFH complement factor H
CGA glycoprotein hormones, alpha polypeptide
CHD7 chromodomain helicase DNA binding protein 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIT1 chitinase 1 (chitotriosidase)
CHUK conserved helix-loop-helix ubiquitous kinase
CKMT1A creatine kinase, mitochondrial 1A
CKMT1B creatine kinase, mitochondrial 1B
CLEC4C C-type lectin domain family 4, member C
CLU clusterin
CMIP c-Maf inducing protein
CNR1 cannabinoid receptor 1 (brain)
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
COL5A1 collagen, type V, alpha 1
COL6A1 collagen, type VI, alpha 1
CRP C-reactive protein, pentraxin-related
CSF1R colony stimulating factor 1 receptor
CSMD1 CUB and Sushi multiple domains 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTSS cathepsin S
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYBB cytochrome b-245, beta polypeptide
CYLD cylindromatosis (turban tumor syndrome)
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFA1 defensin, alpha 1
DMPK dystrophia myotonica-protein kinase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DTNA dystrobrevin, alpha
E2F1 E2F transcription factor 1
EBI3 Epstein-Barr virus induced 3
EGFR epidermal growth factor receptor
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
EPCAM epithelial cell adhesion molecule
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPO erythropoietin
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EXT1 exostosin glycosyltransferase 1
F5 coagulation factor V (proaccelerin, labile factor)
F8 coagulation factor VIII, procoagulant component
FAN1 FANCD2/FANCI-associated nuclease 1
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGF2 fibroblast growth factor 2 (basic)
FGG fibrinogen gamma chain
FLNA filamin A, alpha
FLT3LG fms-related tyrosine kinase 3 ligand
FMOD fibromodulin
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXC2 forkhead box C2
FOXG1 forkhead box G1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FSHR follicle stimulating hormone receptor
FUS FUS RNA binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GALT galactose-1-phosphate uridylyltransferase
GCSAM germinal center-associated, signaling and motility
GJA1 gap junction protein, alpha 1, 43kDa
GJB2 gap junction protein, beta 2, 26kDa
GLA galactosidase, alpha
GLRA1 glycine receptor, alpha 1
GPR39 G protein-coupled receptor 39
GRB2 growth factor receptor-bound protein 2
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HBB hemoglobin, beta
HCK HCK proto-oncogene, Src family tyrosine kinase
HDAC1 histone deacetylase 1
HDAC11 histone deacetylase 11
HES5 hes family bHLH transcription factor 5
HFE hemochromatosis
HHIP hedgehog interacting protein
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HP haptoglobin
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSF1 heat shock transcription factor 1
HSPA4 heat shock 70kDa protein 4
HTN3 histatin 3
HTT huntingtin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL12RB1 interleukin 12 receptor, beta 1
IL17A interleukin 17A
IL19 interleukin 19
IL1B interleukin 1, beta
IL20 interleukin 20
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL24 interleukin 24
IL27 interleukin 27
IL31 interleukin 31
IL33 interleukin 33
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4 interleukin 4
IL6 interleukin 6
INS insulin
IPO4 importin 4
IPO7 importin 7
IRF4 interferon regulatory factor 4
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
JAK2 Janus kinase 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDM1A lysine (K)-specific demethylase 1A
KDR kinase insert domain receptor
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0319 KIAA0319
KLHDC8B kelch domain containing 8B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMA2 laminin, alpha 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LMNA lamin A/C
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK14 mitogen-activated protein kinase 14
MAPK9 mitogen-activated protein kinase 9
MBL2 mannose-binding lectin (protein C) 2, soluble
MBP myelin basic protein
MCM3 minichromosome maintenance complex component 3
MECP2 methyl CpG binding protein 2
MEFV Mediterranean fever
MEN1 multiple endocrine neoplasia I
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MIR410 microRNA 410
MIR9-1 microRNA 9-1
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MPZ myelin protein zero
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MST1R macrophage stimulating 1 receptor
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBPC3 myosin binding protein C, cardiac
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYOG myogenin (myogenic factor 4)
NF1 neurofibromin 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
NIPBL Nipped-B homolog (Drosophila)
NLGN4X neuroligin 4, X-linked
NLRP12 NLR family, pyrin domain containing 12
NOTCH3 notch 3
NQO1 NAD(P)H dehydrogenase, quinone 1
OCRL oculocerebrorenal syndrome of Lowe
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PAH phenylalanine hydroxylase
PANX1 pannexin 1
PAQR5 progestin and adipoQ receptor family member V
PAQR7 progestin and adipoQ receptor family member VII
PAQR8 progestin and adipoQ receptor family member VIII
PARP3 poly (ADP-ribose) polymerase family, member 3
PAX3 paired box 3
PAX5 paired box 5
PAX6 paired box 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PFN1 profilin 1
PGR progesterone receptor
PHF6 PHD finger protein 6
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKP1 plakophilin 1
PLCB2 phospholipase C, beta 2
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLSCR1 phospholipid scramblase 1
PNLIP pancreatic lipase
PNPLA3 patatin-like phospholipase domain containing 3
POLK polymerase (DNA directed) kappa
POU2AF1 POU class 2 associating factor 1
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PROCR protein C receptor, endothelial
PROM1 prominin 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRO protein tyrosine phosphatase, receptor type, O
PTX3 pentraxin 3, long
PYCARD PYD and CARD domain containing
RANBP2 RAN binding protein 2
RB1CC1 RB1-inducible coiled-coil 1
REG4 regenerating islet-derived family, member 4
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RET ret proto-oncogene
RGS16 regulator of G-protein signaling 16
RHO rhodopsin
RHOA ras homolog family member A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPS19 ribosomal protein S19
RXFP1 relaxin/insulin-like family peptide receptor 1
RXFP2 relaxin/insulin-like family peptide receptor 2
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S1PR1 sphingosine-1-phosphate receptor 1
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SCNN1D sodium channel, non voltage gated 1 delta subunit
SEPN1 selenoprotein N, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH2D1A SH2 domain containing 1A
SHH sonic hedgehog
SIL1 SIL1 nucleotide exchange factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SMAD3 SMAD family member 3
SOCS1 suppressor of cytokine signaling 1
SP1 Sp1 transcription factor
SPAST spastin
SPD3 Synpolydactyly 3
SPI1 Spi-1 proto-oncogene
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUSD4 sushi domain containing 4
SV2A synaptic vesicle glycoprotein 2A
SV2B synaptic vesicle glycoprotein 2B
SV2C synaptic vesicle glycoprotein 2C
SYK spleen tyrosine kinase
TAS1R2 taste receptor, type 1, member 2
TAS1R3 taste receptor, type 1, member 3
TCF4 transcription factor 4
TERT telomerase reverse transcriptase
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFR2 transferrin receptor 2
TGFB1 transforming growth factor, beta 1
TIMP2 TIMP metallopeptidase inhibitor 2
TJP1 tight junction protein 1
TLR4 toll-like receptor 4
TNAP TRAFs and NIK-associated protein
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNNI2 troponin I type 2 (skeletal, fast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP63 tumor protein p63
TPP1 tripeptidyl peptidase I
TRAF3 TNF receptor-associated factor 3
TRE17 TRE17 protein
TREML1 triggering receptor expressed on myeloid cells-like 1
TRIM41 tripartite motif containing 41
TTR transthyretin
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TXN thioredoxin
UBQLN1 ubiquilin 1
UBXN4 UBX domain protein 4
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VWF von Willebrand factor
WNT5A wingless-type MMTV integration site family, member 5A
WNT7A wingless-type MMTV integration site family, member 7A
WWOX WW domain containing oxidoreductase
YBX1 Y box binding protein 1