clemizole-2301 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the clemizole-2301 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACRV1 acrosomal vesicle protein 1
ACTN2 actinin, alpha 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALB albumin
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ATF3 activating transcription factor 3
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCAN brevican
BTG2 BTG family, member 2
C17ORF59 chromosome 17 open reading frame 59
C7 complement component 7
CA9 carbonic anhydrase IX
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC28B coiled-coil domain containing 28B
CCDC30 coiled-coil domain containing 30
CD82 CD82 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
COL1A1 collagen, type I, alpha 1
COMT catechol-O-methyltransferase
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DGCR8 DGCR8 microprocessor complex subunit
DICER1 dicer 1, ribonuclease type III
DMP1 dentin matrix acidic phosphoprotein 1
DSC2 desmocollin 2
ECE1 endothelin converting enzyme 1
EGF epidermal growth factor
ESR1 estrogen receptor 1
FANCA Fanconi anemia, complementation group A
FGF17 fibroblast growth factor 17
FRAS1 Fraser extracellular matrix complex subunit 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GCKR glucokinase (hexokinase 4) regulator
GLS glutaminase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GSTTP1 glutathione S-transferase theta pseudogene 1
GYG2 glycogenin 2
HIST1H2AB histone cluster 1, H2ab
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXC4 homeobox C4
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB3 heat shock 27kDa protein 3
ICA1 islet cell autoantigen 1, 69kDa
IDS iduronate 2-sulfatase
KIAA0040 KIAA0040
KITLG KIT ligand
KLHDC8A kelch domain containing 8A
KLK2 kallikrein-related peptidase 2
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LAMP1 lysosomal-associated membrane protein 1
LECT1 leukocyte cell derived chemotaxin 1
LEFTY2 left-right determination factor 2
LMAN1 lectin, mannose-binding, 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPY2R neuropeptide Y receptor Y2
NR5A2 nuclear receptor subfamily 5, group A, member 2
PENK proenkephalin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLK3 polo-like kinase 3
PML promyelocytic leukemia
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PQLC3 PQ loop repeat containing 3
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKCE protein kinase C, epsilon
PRMT2IP PRMT2 interacting protein
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RND1 Rho family GTPase 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPS3A ribosomal protein S3A
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SERHL2 serine hydrolase-like 2
SH3BP2 SH3-domain binding protein 2
SIRT5 sirtuin 5
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC45A2 solute carrier family 45, member 2
SNCG synuclein, gamma (breast cancer-specific protein 1)
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
STK17A serine/threonine kinase 17a
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCF12 transcription factor 12
TIAM2 T-cell lymphoma invasion and metastasis 2
TM4SF5 transmembrane 4 L six family member 5
TNS1 tensin 1
TSC22D4 TSC22 domain family, member 4
TUBA4B tubulin, alpha 4b
WDR62 WD repeat domain 62
ZC3H7B zinc finger CCCH-type containing 7B
ZER1 zyg-11 related, cell cycle regulator
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ACVR2A activin A receptor, type IIA
ADGRE5 adhesion G protein-coupled receptor E5
AFAP1 actin filament associated protein 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARMC7 armadillo repeat containing 7
ARSB arylsulfatase B
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BBC3 BCL2 binding component 3
C14ORF93 chromosome 14 open reading frame 93
C22ORF29 chromosome 22 open reading frame 29
C5 complement component 5
CBX8 chromobox homolog 8
CCDC132 coiled-coil domain containing 132
CCDC85C coiled-coil domain containing 85C
CCNO cyclin O
CDK20 cyclin-dependent kinase 20
CHML choroideremia-like (Rab escort protein 2)
CLCN5 chloride channel, voltage-sensitive 5
CLCN6 chloride channel, voltage-sensitive 6
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRYBG3 beta-gamma crystallin domain containing 3
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DNM1 dynamin 1
EIF5A2 eukaryotic translation initiation factor 5A2
ETAA1 Ewing tumor-associated antigen 1
F2R coagulation factor II (thrombin) receptor
FAM131A family with sequence similarity 131, member A
FKBP14 FK506 binding protein 14, 22 kDa
FLT4 fms-related tyrosine kinase 4
FMO4 flavin containing monooxygenase 4
GCHFR GTP cyclohydrolase I feedback regulator
GPATCH2L G patch domain containing 2-like
GPX2 glutathione peroxidase 2
GSTM5 glutathione S-transferase mu 5
GSTT1 glutathione S-transferase theta 1
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1D histone cluster 1, H1d
HIST1H2AI histone cluster 1, H2ai
IDI2-AS1 IDI2 antisense RNA 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEL Kell blood group, metallo-endopeptidase
MAGEB2 melanoma antigen family B2
MANBA mannosidase, beta A, lysosomal
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MRPL44 mitochondrial ribosomal protein L44
MUC3A mucin 3A, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYO1F myosin IF
NEK11 NIMA-related kinase 11
NES nestin
NPIPB15 nuclear pore complex interacting protein family, member B15
NRSN2 neurensin 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PALM paralemmin
PCDHB13 protocadherin beta 13
PCDHB8 protocadherin beta 8
PCDHGB5 protocadherin gamma subfamily B, 5
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRF1 perforin 1 (pore forming protein)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTK6 protein tyrosine kinase 6
PTPRS protein tyrosine phosphatase, receptor type, S
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RLN1 relaxin 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF122 ring finger protein 122
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
TAOK1 TAO kinase 1
TCP10 t-complex 10
TESC tescalcin
TFF2 trefoil factor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPAN5 tetraspanin 5
TTC30A tetratricopeptide repeat domain 30A
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
USP27X ubiquitin specific peptidase 27, X-linked
VWA1 von Willebrand factor A domain containing 1
ZNF16 zinc finger protein 16
ZNF365 zinc finger protein 365
ZNF696 zinc finger protein 696
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862
ZSCAN26 zinc finger and SCAN domain containing 26