clemizole-2339 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the clemizole-2339 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX1 acyl-CoA oxidase 1, palmitoyl
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCY9 adenylate cyclase 9
ARHGAP10 Rho GTPase activating protein 10
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARNT aryl hydrocarbon receptor nuclear translocator
BMP7 bone morphogenetic protein 7
C16ORF58 chromosome 16 open reading frame 58
C8ORF44 chromosome 8 open reading frame 44
CAPRIN2 caprin family member 2
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCPG1 cell cycle progression 1
CD47 CD47 molecule
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CECR1 cat eye syndrome chromosome region, candidate 1
CLSTN2 calsyntenin 2
CNR2 cannabinoid receptor 2 (macrophage)
COL1A2 collagen, type I, alpha 2
CPM carboxypeptidase M
CREM cAMP responsive element modulator
CRIP1 cysteine-rich protein 1 (intestinal)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSF1 colony stimulating factor 1 (macrophage)
CTC1 CTS telomere maintenance complex component 1
DGAT1 diacylglycerol O-acyltransferase 1
DLC1 DLC1 Rho GTPase activating protein
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DNASE2 deoxyribonuclease II, lysosomal
DNMBP dynamin binding protein
E2F1 E2F transcription factor 1
ELK1 ELK1, member of ETS oncogene family
ELOVL6 ELOVL fatty acid elongase 6
EML2 echinoderm microtubule associated protein like 2
FAM184A family with sequence similarity 184, member A
FAM3A family with sequence similarity 3, member A
FNDC3A fibronectin type III domain containing 3A
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GK glycerol kinase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNS glucosamine (N-acetyl)-6-sulfatase
HSF1 heat shock transcription factor 1
IFT46 intraflagellar transport 46
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INPP5K inositol polyphosphate-5-phosphatase K
KAZN kazrin, periplakin interacting protein
LIMD2 LIM domain containing 2
LIN7C lin-7 homolog C (C. elegans)
LINC00597 long intergenic non-protein coding RNA 597
LPAR2 lysophosphatidic acid receptor 2
LPPR3 lipid phosphate phosphatase-related protein type 3
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MARK4 MAP/microtubule affinity-regulating kinase 4
MBTPS2 membrane-bound transcription factor peptidase, site 2
MKL1 megakaryoblastic leukemia (translocation) 1
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NOL12 nucleolar protein 12
NUMA1 nuclear mitotic apparatus protein 1
OAZ3 ornithine decarboxylase antizyme 3
ORAI2 ORAI calcium release-activated calcium modulator 2
PCDHGB5 protocadherin gamma subfamily B, 5
PCNX pecanex homolog (Drosophila)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDLIM5 PDZ and LIM domain 5
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCG1 phospholipase C, gamma 1
PLK3 polo-like kinase 3
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
PPAP2A phosphatidic acid phosphatase type 2A
PPP1R3D protein phosphatase 1, regulatory subunit 3D
QTRT1 queuine tRNA-ribosyltransferase 1
RAD50 RAD50 homolog (S. cerevisiae)
RBKS ribokinase
RBM19 RNA binding motif protein 19
RCAN1 regulator of calcineurin 1
RGS10 regulator of G-protein signaling 10
RIN3 Ras and Rab interactor 3
RNF122 ring finger protein 122
RPS4Y1 ribosomal protein S4, Y-linked 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIL1 SIL1 nucleotide exchange factor
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLITRK5 SLIT and NTRK-like family, member 5
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOS2 son of sevenless homolog 2 (Drosophila)
SRPR signal recognition particle receptor (docking protein)
STXBP1 syntaxin binding protein 1
SYNGR1 synaptogyrin 1
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TK2 thymidine kinase 2, mitochondrial
TLE3 transducin-like enhancer of split 3
TM7SF2 transmembrane 7 superfamily member 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIM29 tripartite motif containing 29
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WSB1 WD repeat and SOCS box containing 1
ZNF354A zinc finger protein 354A
ZNF573 zinc finger protein 573
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABHD3 abhydrolase domain containing 3
ACPP acid phosphatase, prostate
ADAP2 ArfGAP with dual PH domains 2
ANKRD36 ankyrin repeat domain 36
ATG9A autophagy related 9A
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BMP15 bone morphogenetic protein 15
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C1ORF54 chromosome 1 open reading frame 54
C7ORF69 chromosome 7 open reading frame 69
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK3 cyclin-dependent kinase 3
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CISH cytokine inducible SH2-containing protein
CSF1R colony stimulating factor 1 receptor
CXCR2 chemokine (C-X-C motif) receptor 2
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DRAM1 DNA-damage regulated autophagy modulator 1
DSE dermatan sulfate epimerase
DSPP dentin sialophosphoprotein
DUSP5 dual specificity phosphatase 5
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ETV4 ets variant 4
FILIP1L filamin A interacting protein 1-like
FKBPL FK506 binding protein like
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GAB2 GRB2-associated binding protein 2
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR27 G protein-coupled receptor 27
HIST1H2AJ histone cluster 1, H2aj
HP haptoglobin
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IRF9 interferon regulatory factor 9
ITGB7 integrin, beta 7
JUNB jun B proto-oncogene
KDM5C lysine (K)-specific demethylase 5C
KIF3B kinesin family member 3B
KLF1 Kruppel-like factor 1 (erythroid)
KRI1 KRI1 homolog (S. cerevisiae)
LAX1 lymphocyte transmembrane adaptor 1
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
MAPK3 mitogen-activated protein kinase 3
METTL16 methyltransferase like 16
METTL2B methyltransferase like 2B
MILR1 mast cell immunoglobulin-like receptor 1
MMP9 matrix metallopeptidase 9
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MYO19 myosin XIX
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NIPAL2 NIPA-like domain containing 2
NT5M 5',3'-nucleotidase, mitochondrial
NTSR1 neurotensin receptor 1 (high affinity)
P3H1 prolyl 3-hydroxylase 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PNMA1 paraneoplastic Ma antigen 1
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POR P450 (cytochrome) oxidoreductase
PWAR5 Prader Willi/Angelman region RNA 5
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RANGRF RAN guanine nucleotide release factor
RCAN3 RCAN family member 3
RIN1 Ras and Rab interactor 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF167 ring finger protein 167
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLFN12 schlafen family member 12
SMR3A submaxillary gland androgen regulated protein 3A
SNX15 sorting nexin 15
SPATA2L spermatogenesis associated 2-like
SPIDR scaffolding protein involved in DNA repair
SREK1IP1 SREK1-interacting protein 1
STIM1 stromal interaction molecule 1
SUGP1 SURP and G patch domain containing 1
TCEA2 transcription elongation factor A (SII), 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIGD6 tigger transposable element derived 6
TMEM134 transmembrane protein 134
TMEM212 transmembrane protein 212
TOLLIP toll interacting protein
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TUBA3C tubulin, alpha 3c
VNN2 vanin 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF426 zinc finger protein 426
ZNF480 zinc finger protein 480
ZNF668 zinc finger protein 668
ZNF701 zinc finger protein 701
ZNF747 zinc finger protein 747
ZNF770 zinc finger protein 770
ZNHIT2 zinc finger, HIT-type containing 2