clemizole-7371 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the clemizole-7371 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRL1 adhesion G protein-coupled receptor L1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ARHGAP26 Rho GTPase activating protein 26
ARHGAP35 Rho GTPase activating protein 35
ATF7IP activating transcription factor 7 interacting protein
ATP10A ATPase, class V, type 10A
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BAIAP3 BAI1-associated protein 3
BMP2 bone morphogenetic protein 2
CASS4 Cas scaffolding protein family member 4
CDC25C cell division cycle 25C
CDH10 cadherin 10, type 2 (T2-cadherin)
CELA2A chymotrypsin-like elastase family, member 2A
CHRM5 cholinergic receptor, muscarinic 5
CLCN6 chloride channel, voltage-sensitive 6
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CPA2 carboxypeptidase A2 (pancreatic)
CREB5 cAMP responsive element binding protein 5
CROCC ciliary rootlet coiled-coil, rootletin
CSHL1 chorionic somatomammotropin hormone-like 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DNPEP aspartyl aminopeptidase
DOK4 docking protein 4
EDNRA endothelin receptor type A
EFNB1 ephrin-B1
EFS embryonal Fyn-associated substrate
EGR1 early growth response 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EMID1 EMI domain containing 1
ENOX2 ecto-NOX disulfide-thiol exchanger 2
FXYD2 FXYD domain containing ion transport regulator 2
GPR161 G protein-coupled receptor 161
HIP1 huntingtin interacting protein 1
HRK harakiri, BCL2 interacting protein
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFNA2 interferon, alpha 2
IL5RA interleukin 5 receptor, alpha
IRAK3 interleukin-1 receptor-associated kinase 3
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KRT20 keratin 20, type I
LAMC3 laminin, gamma 3
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LGALS9 lectin, galactoside-binding, soluble, 9
LIN7B lin-7 homolog B (C. elegans)
LST1 leukocyte specific transcript 1
MAGEC3 melanoma antigen family C3
MAU2 MAU2 sister chromatid cohesion factor
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRAS muscle RAS oncogene homolog
MXRA8 matrix-remodelling associated 8
MYBPC3 myosin binding protein C, cardiac
MYH15 myosin, heavy chain 15
MYO1F myosin IF
NPAP1 nuclear pore associated protein 1
NRG1 neuregulin 1
NUP214 nucleoporin 214kDa
OASL 2'-5'-oligoadenylate synthetase-like
PAX4 paired box 4
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDE4C phosphodiesterase 4C, cAMP-specific
PER1 period circadian clock 1
PEX3 peroxisomal biogenesis factor 3
PEX6 peroxisomal biogenesis factor 6
PILRA paired immunoglobin-like type 2 receptor alpha
PKNOX2 PBX/knotted 1 homeobox 2
POU6F1 POU class 6 homeobox 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRSS50 protease, serine, 50
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RHO rhodopsin
RUNX1 runt-related transcription factor 1
S1PR1 sphingosine-1-phosphate receptor 1
SAMD4B sterile alpha motif domain containing 4B
SC5D sterol-C5-desaturase
SH2D3A SH2 domain containing 3A
SHBG sex hormone-binding globulin
SLC16A6 solute carrier family 16, member 6
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRPX2 sushi-repeat containing protein, X-linked 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP4 STEAP family member 4
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBXA2R thromboxane A2 receptor
TJAP1 tight junction associated protein 1 (peripheral)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
VNN2 vanin 2
XYLB xylulokinase homolog (H. influenzae)
ZCCHC4 zinc finger, CCHC domain containing 4
ZER1 zyg-11 related, cell cycle regulator
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF155 zinc finger protein 155
ZNF471 zinc finger protein 471
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACVR2B activin A receptor, type IIB
ADGRF1 adhesion G protein-coupled receptor F1
ALS2CL ALS2 C-terminal like
ANOS1 anosmin 1
BAK1 BCL2-antagonist/killer 1
BDNF brain-derived neurotrophic factor
BIRC3 baculoviral IAP repeat containing 3
C17ORF62 chromosome 17 open reading frame 62
C1ORF159 chromosome 1 open reading frame 159
C8ORF60 chromosome 8 open reading frame 60
C9ORF91 chromosome 9 open reading frame 91
CBX7 chromobox homolog 7
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCS copper chaperone for superoxide dismutase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHMP7 charged multivesicular body protein 7
CPA4 carboxypeptidase A4
CRIP1 cysteine-rich protein 1 (intestinal)
CST6 cystatin E/M
CTSK cathepsin K
DCAF17 DDB1 and CUL4 associated factor 17
DCLRE1A DNA cross-link repair 1A
DHRS11 dehydrogenase/reductase (SDR family) member 11
EMD emerin
ERN2 endoplasmic reticulum to nucleus signaling 2
FEM1C fem-1 homolog c (C. elegans)
FHOD1 formin homology 2 domain containing 1
FOXC1 forkhead box C1
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FZD3 frizzled class receptor 3
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLT8D2 glycosyltransferase 8 domain containing 2
GPALPP1 GPALPP motifs containing 1
HEATR3 HEAT repeat containing 3
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HOXC10 homeobox C10
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INF2 inverted formin, FH2 and WH2 domain containing
ISL1 ISL LIM homeobox 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0556 KIAA0556
KLC2 kinesin light chain 2
KLF7 Kruppel-like factor 7 (ubiquitous)
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAP1S microtubule-associated protein 1S
MEIS1 Meis homeobox 1
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MXD3 MAX dimerization protein 3
MYO1D myosin ID
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NINJ1 ninjurin 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PARD6A par-6 family cell polarity regulator alpha
PARM1 prostate androgen-regulated mucin-like protein 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G15 phospholipase A2, group XV
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPT2 palmitoyl-protein thioesterase 2
PRMT7 protein arginine methyltransferase 7
RAB33B RAB33B, member RAS oncogene family
RBL1 retinoblastoma-like 1
RIN1 Ras and Rab interactor 1
RPGR retinitis pigmentosa GTPase regulator
SIPA1 signal-induced proliferation-associated 1
SLITRK5 SLIT and NTRK-like family, member 5
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SNIP1 Smad nuclear interacting protein 1
SNPH syntaphilin
SNTA1 syntrophin, alpha 1
SPATA7 spermatogenesis associated 7
SPEG SPEG complex locus
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STIM1 stromal interaction molecule 1
SUGCT succinyl-CoA:glutarate-CoA transferase
SYNPO synaptopodin
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTA T-cell leukemia translocation altered
TH tyrosine hydroxylase
TMEM132A transmembrane protein 132A
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TOR1B torsin family 1, member B (torsin B)
TRAPPC6A trafficking protein particle complex 6A
UBXN6 UBX domain protein 6
UGT8 UDP glycosyltransferase 8
URGCP upregulator of cell proliferation
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WSCD1 WSC domain containing 1
ZBTB10 zinc finger and BTB domain containing 10
ZBTB3 zinc finger and BTB domain containing 3
ZDHHC11 zinc finger, DHHC-type containing 11
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF14 zinc finger protein 14
ZNF189 zinc finger protein 189
ZNF350 zinc finger protein 350
ZNF552 zinc finger protein 552
ZNF692 zinc finger protein 692