clidinium Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
Description The ester resulting from formal condensation of benzilic acid and 3-hydroxy-1-methyl-1-azoniabicyclo[2.2.2]octane. It is used, generally as the bromide, for the symptomatic treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome. (Chemical Entities of Biological Interest Ontology, CHEBI_3743)
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Genes

542 genes differentially expressed following the clidinium small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 10.0722
ASCC3 activating signal cointegrator 1 complex subunit 3 5.69941
MIEF1 mitochondrial elongation factor 1 5.44474
CDK2 cyclin-dependent kinase 2 5.03138
ZNF550 zinc finger protein 550 4.9576
DCTD dCMP deaminase 4.73314
MOB1A MOB kinase activator 1A 4.58023
GYG2 glycogenin 2 4.5398
JPT2 Jupiter microtubule associated homolog 2 4.47999
UFM1 ubiquitin-fold modifier 1 4.4602
FBXL7 F-box and leucine-rich repeat protein 7 4.42339
PIEZO2 piezo-type mechanosensitive ion channel component 2 4.37348
IQGAP1 IQ motif containing GTPase activating protein 1 4.36238
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 4.33193
XPOT exportin, tRNA 4.31513
LUC7L2 LUC7-like 2 (S. cerevisiae) 4.30497
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 4.30174
GFRA3 GDNF family receptor alpha 3 4.20719
TMEM109 transmembrane protein 109 4.1997
CBX1 chromobox homolog 1 4.19728
RALB v-ral simian leukemia viral oncogene homolog B 4.19078
CDH5 cadherin 5, type 2 (vascular endothelium) 4.14515
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 4.14507
ZNF106 zinc finger protein 106 4.08828
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 4.08625
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 4.07237
FAT4 FAT atypical cadherin 4 4.05762
RS1 retinoschisin 1 4.05358
PPP1R17 protein phosphatase 1, regulatory subunit 17 4.05343
GRP gastrin-releasing peptide 4.0512
APLP2 amyloid beta (A4) precursor-like protein 2 4.04956
SOX10 SRY (sex determining region Y)-box 10 4.04642
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 4.03824
GJA5 gap junction protein, alpha 5, 40kDa 4.03188
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 4.02931
HBE1 hemoglobin, epsilon 1 4.02479
RAMP2 receptor (G protein-coupled) activity modifying protein 2 4.0151
IL3 interleukin 3 3.99575
FHOD3 formin homology 2 domain containing 3 3.98269
GPR15 G protein-coupled receptor 15 3.98052
OTUD4 OTU deubiquitinase 4 3.97615
IPO8 importin 8 3.97138
PHF10 PHD finger protein 10 3.96154
DONSON downstream neighbor of SON 3.95065
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 3.94981
PRDM13 PR domain containing 13 3.89094
WNT7A wingless-type MMTV integration site family, member 7A 3.87354
LRRC3 leucine rich repeat containing 3 3.87267
OR2F2 olfactory receptor, family 2, subfamily F, member 2 3.86852
RBMY2FP RNA binding motif protein, Y-linked, family 2, member F pseudogene 3.8551
PRRC2C proline-rich coiled-coil 2C 3.8527
TRHR thyrotropin-releasing hormone receptor 3.84954
METTL13 methyltransferase like 13 3.84584
DOCK10 dedicator of cytokinesis 10 3.83805
BAHD1 bromo adjacent homology domain containing 1 3.83803
TGOLN2 trans-golgi network protein 2 3.82713
FAM20B family with sequence similarity 20, member B 3.82579
PRAMEF11 PRAME family member 11 3.82516
MYO10 myosin X 3.81053
INSL6 insulin-like 6 3.8076
TNNI3 troponin I type 3 (cardiac) 3.78593
WNK1 WNK lysine deficient protein kinase 1 3.78097
POU3F3 POU class 3 homeobox 3 3.78007
DKK4 dickkopf WNT signaling pathway inhibitor 4 3.77672
PRDX6 peroxiredoxin 6 3.77609
OR11A1 olfactory receptor, family 11, subfamily A, member 1 3.7721
FDPS farnesyl diphosphate synthase 3.75829
TACR3 tachykinin receptor 3 3.75793
C6ORF62 chromosome 6 open reading frame 62 3.74624
IKZF3 IKAROS family zinc finger 3 (Aiolos) 3.74363
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 3.73653
ZNF391 zinc finger protein 391 3.73551
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 3.73329
GRIK4 glutamate receptor, ionotropic, kainate 4 3.73256
ADCY7 adenylate cyclase 7 3.72478
C5ORF22 chromosome 5 open reading frame 22 3.70829
HERC2P3 hect domain and RLD 2 pseudogene 3 3.69395
MYH4 myosin, heavy chain 4, skeletal muscle 3.67989
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 3.67512
KANSL3 KAT8 regulatory NSL complex subunit 3 3.66966
ARHGAP19 Rho GTPase activating protein 19 3.66825
XPO1 exportin 1 3.65499
HLA-C major histocompatibility complex, class I, C 3.65475
AMBN ameloblastin (enamel matrix protein) 3.64381
RAB30 RAB30, member RAS oncogene family 3.63728
ZNF638 zinc finger protein 638 3.63532
EFCC1 EF-hand and coiled-coil domain containing 1 3.63056
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 3.6277
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 3.62229
MDFIC MyoD family inhibitor domain containing 3.62004
TJP1 tight junction protein 1 3.61441
LAMB1 laminin, beta 1 3.60256
CALCB calcitonin-related polypeptide beta 3.60056
CARD14 caspase recruitment domain family, member 14 3.60039
ERBIN erbb2 interacting protein 3.59279
IARS1 isoleucyl-tRNA synthetase 1 3.59004
DEK DEK proto-oncogene 3.58547
PRAMEF12 PRAME family member 12 3.57769
SRSF7 serine/arginine-rich splicing factor 7 3.57584
FOXD3 forkhead box D3 3.57474
FOXD2 forkhead box D2 3.57401
IL9 interleukin 9 3.56109
CST5 cystatin D 3.55599
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) 3.54153
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 3.53932
SKA1 spindle and kinetochore associated complex subunit 1 3.5324
ZNF215 zinc finger protein 215 3.5226
MFGE8 milk fat globule-EGF factor 8 protein 3.52249
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 3.51589
SMAD9 SMAD family member 9 3.51401
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 3.51341
IVNS1ABP influenza virus NS1A binding protein 3.50993
NBR1 neighbor of BRCA1 gene 1 3.5091
OR51E2 olfactory receptor, family 51, subfamily E, member 2 3.49895
SEC14L1 SEC14-like 1 (S. cerevisiae) 3.49657
PITPNM3 PITPNM family member 3 3.4879
GPR68 G protein-coupled receptor 68 3.48575
RHOA ras homolog family member A 3.47975
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 3.47407
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 3.47142
MACROH2A2 macroH2A.2 histone 3.47137
HSPA4 heat shock 70kDa protein 4 3.47091
ZNF41 zinc finger protein 41 3.46802
KCNK2 potassium channel, two pore domain subfamily K, member 2 3.45474
TRIM22 tripartite motif containing 22 3.45192
GJC1 gap junction protein, gamma 1, 45kDa 3.44858
MIA melanoma inhibitory activity 3.44237
KLHL11 kelch-like family member 11 3.44059
MTO1 mitochondrial tRNA translation optimization 1 3.4404
COLEC12 collectin sub-family member 12 3.43845
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 3.43819
GPR87 G protein-coupled receptor 87 3.43035
MYO3A myosin IIIA 3.42708
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 3.42696
ADAR adenosine deaminase, RNA-specific 3.42035
PNOC prepronociceptin 3.41419
ZNF682 zinc finger protein 682 3.41212
GOLPH3 golgi phosphoprotein 3 (coat-protein) 3.40504
NELL2 NEL-like 2 (chicken) 3.39899
ZNF749 zinc finger protein 749 3.39765
CAPRIN1 cell cycle associated protein 1 3.3971
ASB4 ankyrin repeat and SOCS box containing 4 3.39299
CBX2 chromobox homolog 2 3.38793
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 3.38764
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) 3.38668
ZC3H13 zinc finger CCCH-type containing 13 3.38325
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 3.3824
POM121L2 POM121 transmembrane nucleoporin-like 2 3.38165
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 3.38041
PCBP1 poly(rC) binding protein 1 3.36717
USP1 ubiquitin specific peptidase 1 3.3635
OR10H2 olfactory receptor, family 10, subfamily H, member 2 3.3602
HOXC13 homeobox C13 3.35165
TCP11L1 t-complex 11, testis-specific-like 1 3.34991
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 3.34869
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 3.34754
ITPRID2 ITPR interacting domain containing 2 3.34428
ZNF460 zinc finger protein 460 3.34306
CCL1 chemokine (C-C motif) ligand 1 3.33504
PARVB parvin, beta 3.33458
ERMP1 endoplasmic reticulum metallopeptidase 1 3.33424
FBXL5 F-box and leucine-rich repeat protein 5 3.33417
LCN1 lipocalin 1 3.33195
OR1A2 olfactory receptor, family 1, subfamily A, member 2 3.32581
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 3.32472
TUG1 taurine up-regulated 1 (non-protein coding) 3.32133
MCF2 MCF.2 cell line derived transforming sequence 3.31742
TGM2 transglutaminase 2 3.30412
NOTCH2 notch 2 3.30348
KCNK13 potassium channel, two pore domain subfamily K, member 13 3.29373
CCT2 chaperonin containing TCP1, subunit 2 (beta) 3.2931
MDC1 mediator of DNA-damage checkpoint 1 3.29188
NPBWR2 neuropeptides B/W receptor 2 3.28478
AP2B1 adaptor-related protein complex 2, beta 1 subunit 3.28196
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 3.27699
DUSP14 dual specificity phosphatase 14 3.27368
RBM23 RNA binding motif protein 23 3.26908
ECPAS Ecm29 proteasome adaptor and scaffold 3.26718
FBXW11 F-box and WD repeat domain containing 11 3.26651
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 3.26409
ADGRE1 adhesion G protein-coupled receptor E1 3.25989
OR6A2 olfactory receptor, family 6, subfamily A, member 2 3.25833
ULK4 unc-51 like kinase 4 3.25218
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 3.24641
SMC1A structural maintenance of chromosomes 1A 3.24372
TSPAN8 tetraspanin 8 3.23669
OR7A10 olfactory receptor, family 7, subfamily A, member 10 3.23504
SOX5 SRY (sex determining region Y)-box 5 3.23326
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 3.23241
SKIC3 SKI3 subunit of superkiller complex 3.23209
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.23059
PITPNB phosphatidylinositol transfer protein, beta 3.22991
ACSL1 acyl-CoA synthetase long-chain family member 1 3.22903
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 3.2273
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 3.2265
NCBP1 nuclear cap binding protein subunit 1, 80kDa 3.22273
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 3.22211
TATDN2 TatD DNase domain containing 2 3.22165
WWTR1 WW domain containing transcription regulator 1 3.22153
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 3.22035
NCSTN nicastrin 3.21355
FUS FUS RNA binding protein 3.21215
SRY sex determining region Y 3.20296
TARS1 threonyl-tRNA synthetase 1 3.20142
SERBP1 SERPINE1 mRNA binding protein 1 3.19835
CLDN11 claudin 11 3.19833
RLN1 relaxin 1 3.19401
TSSK1B testis-specific serine kinase 1B 3.19283
ADAM29 ADAM metallopeptidase domain 29 3.19281
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 3.19108
CALCRL calcitonin receptor-like 3.18662
DKK3 dickkopf WNT signaling pathway inhibitor 3 3.18433
ZNF711 zinc finger protein 711 3.18262
IL4 interleukin 4 3.18188
RANBP9 RAN binding protein 9 3.17238
CD8B CD8b molecule 3.17054
TOB1 transducer of ERBB2, 1 3.16818
MAL mal, T-cell differentiation protein 3.16513
FAF1 Fas (TNFRSF6) associated factor 1 3.1643
KIF2A kinesin heavy chain member 2A 3.16311
ANAPC1 anaphase promoting complex subunit 1 3.16289
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 3.16276
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.1621
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 3.16093
TLX1 T-cell leukemia homeobox 1 3.15565
IK IK cytokine, down-regulator of HLA II 3.1544
TJP2 tight junction protein 2 3.15306
MSH4 mutS homolog 4 3.15302
CA6 carbonic anhydrase VI 3.14822
KRTAP9-9 keratin associated protein 9-9 3.14343
IFI44 interferon-induced protein 44 3.14125
GAS8-AS1 GAS8 antisense RNA 1 3.13717
SRF serum response factor (c-fos serum response element-binding transcription factor) 3.13622
TDRKH tudor and KH domain containing 3.13268
NKX6-1 NK6 homeobox 1 3.13168
SP2 Sp2 transcription factor 3.12739
LGALS14 lectin, galactoside-binding, soluble, 14 3.12617
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.12505
GCM1 glial cells missing homolog 1 (Drosophila) 3.12389
S100A5 S100 calcium binding protein A5 3.12217
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 3.12112
GLO1 glyoxalase I 3.12064
CDK17 cyclin-dependent kinase 17 3.11961
ZNF532 zinc finger protein 532 3.11919
FBXO24 F-box protein 24 3.1184
FKBP10 FK506 binding protein 10, 65 kDa 3.11701
TCP1 t-complex 1 3.11055
RAP1B RAP1B, member of RAS oncogene family 3.10731
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 3.10543
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 3.09878
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 3.09723
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.09709
PTPRJ protein tyrosine phosphatase, receptor type, J 3.09515
CLEC2D C-type lectin domain family 2, member D 3.08923
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.08702
ZNF480 zinc finger protein 480 3.08623
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 3.08527
EPRS1 glutamyl-prolyl-tRNA synthetase 1 3.08201
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 3.07966
ZNF217 zinc finger protein 217 3.07952
ZNF549 zinc finger protein 549 3.07486
TNP2 transition protein 2 (during histone to protamine replacement) 3.07292
TSPAN32 tetraspanin 32 3.07218
NFYB nuclear transcription factor Y, beta 3.07034
SMC4 structural maintenance of chromosomes 4 3.06605
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 3.05716
TEX261 testis expressed 261 3.05613
SIGMAR1 sigma non-opioid intracellular receptor 1 3.05544
ARNT aryl hydrocarbon receptor nuclear translocator 3.05485
PROP1 PROP paired-like homeobox 1 3.04861
TGM5 transglutaminase 5 3.04578
APOL6 apolipoprotein L, 6 3.04432
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 3.04048
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 3.03646
SLC39A1 solute carrier family 39 (zinc transporter), member 1 3.03543
IQCA1 IQ motif containing with AAA domain 1 3.03329
ANGPT2 angiopoietin 2 3.0307
ZBTB14 zinc finger and BTB domain containing 14 3.02908
IL10RA interleukin 10 receptor, alpha 3.02817
FGF22 fibroblast growth factor 22 3.02758
ADNP activity-dependent neuroprotector homeobox 3.02716
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 3.02692
PCDHGB4 protocadherin gamma subfamily B, 4 3.0264
EPHA5 EPH receptor A5 3.026
GJB5 gap junction protein, beta 5, 31.1kDa 3.02538
PSIP1 PC4 and SFRS1 interacting protein 1 3.02537
FAM168B family with sequence similarity 168, member B 3.02526
RAB3D RAB3D, member RAS oncogene family 3.02483
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 3.02375
NOAZFP nucleolar atypical zinc finger 3.02109
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 3.02077
CD4 CD4 molecule 3.01654
ISOC1 isochorismatase domain containing 1 3.01447
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 3.01421
ZNF81 zinc finger protein 81 3.01311
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 3.01225
SSTR4 somatostatin receptor 4 3.0119
TRAPPC10 trafficking protein particle complex 10 3.01174
AMHR2 anti-Mullerian hormone receptor, type II 3.00983
SAMHD1 SAM domain and HD domain 1 3.00949
HAX1 HCLS1 associated protein X-1 3.00444
COL4A2 collagen, type IV, alpha 2 3.00273
HNRNPR heterogeneous nuclear ribonucleoprotein R 3.00145
SP140 SP140 nuclear body protein 3.0003

decreased expression

Symbol Name Standardized Value
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase -5.79708
WSB1 WD repeat and SOCS box containing 1 -5.56525
DCAF13 DDB1 and CUL4 associated factor 13 -5.09898
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 -4.90653
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -4.71683
KLF9 Kruppel-like factor 9 -4.61352
FHIT fragile histidine triad -4.60638
RAB31 RAB31, member RAS oncogene family -4.57376
RASA2 RAS p21 protein activator 2 -4.37592
GRAMD4 GRAM domain containing 4 -4.37428
SURF1 surfeit 1 -4.36511
KIAA0319L KIAA0319-like -4.35614
CFAP74 cilia and flagella associated protein 74 -4.35146
BBX bobby sox homolog (Drosophila) -4.33427
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -4.30103
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 -4.29013
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -4.26978
CERT1 ceramide transporter 1 -4.26506
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.26241
CPNE1 copine I -4.20788
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 -4.19916
UNC13A unc-13 homolog A (C. elegans) -4.19778
EIPR1 EARP complex and GARP complex interacting protein 1 -4.17586
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.16685
ADM adrenomedullin -4.15855
ZNF423 zinc finger protein 423 -4.15533
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -4.15508
COX11 COX11 cytochrome c oxidase copper chaperone -4.14466
IL1B interleukin 1, beta -4.12241
CNPPD1 cyclin Pas1/PHO80 domain containing 1 -4.10438
CXCL3 chemokine (C-X-C motif) ligand 3 -4.10243
GTPBP8 GTP-binding protein 8 (putative) -4.0965
ZBTB43 zinc finger and BTB domain containing 43 -4.07933
ENC1 ectodermal-neural cortex 1 (with BTB domain) -4.05225
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -4.04778
MILR1 mast cell immunoglobulin-like receptor 1 -4.03745
MMP9 matrix metallopeptidase 9 -4.00785
KIF3B kinesin family member 3B -4.00542
ATP2A3 ATPase, Ca++ transporting, ubiquitous -3.98586
SIGLEC15 sialic acid binding Ig-like lectin 15 -3.98121
ZNF91 zinc finger protein 91 -3.96906
LDAF1 lipid droplet assembly factor 1 -3.9659
MT1F metallothionein 1F -3.9395
ICOSLG inducible T-cell co-stimulator ligand -3.91699
RETN resistin -3.91426
INTS11 integrator complex subunit 11 -3.89303
KYAT1 kynurenine aminotransferase 1 -3.88724
MUTYH mutY homolog -3.86115
TMEM260 transmembrane protein 260 -3.85938
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.85669
ABHD18 abhydrolase domain containing 18 -3.80333
MYF5 myogenic factor 5 -3.79341
TMEM212 transmembrane protein 212 -3.78573
JUND jun D proto-oncogene -3.78519
PTGDR2 prostaglandin D2 receptor 2 -3.7843
KRAS Kirsten rat sarcoma viral oncogene homolog -3.78353
CUL5 cullin 5 -3.77106
TFB1M transcription factor B1, mitochondrial -3.76373
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 -3.76006
VPREB1 pre-B lymphocyte 1 -3.75818
ZC4H2 zinc finger, C4H2 domain containing -3.7576
LYRM4 LYR motif containing 4 -3.75579
FLCN folliculin -3.7519
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 -3.75079
MACROD1 MACRO domain containing 1 -3.74586
RPH3A rabphilin 3A -3.72847
CD28 CD28 molecule -3.72767
RHOB ras homolog family member B -3.69777
RYBP RING1 and YY1 binding protein -3.69412
ZNF430 zinc finger protein 430 -3.69123
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q -3.68701
CIB1 calcium and integrin binding 1 (calmyrin) -3.6771
WRNIP1 Werner helicase interacting protein 1 -3.67334
ZNF224 zinc finger protein 224 -3.66889
LRRK1 leucine-rich repeat kinase 1 -3.66467
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -3.66204
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) -3.65501
GPBP1L1 GC-rich promoter binding protein 1-like 1 -3.65065
NRIP3 nuclear receptor interacting protein 3 -3.65063
RIN2 Ras and Rab interactor 2 -3.62678
TERF2 telomeric repeat binding factor 2 -3.6234
AMPD3 adenosine monophosphate deaminase 3 -3.62194
TSPOAP1 TSPO associated protein 1 -3.61372
IQCK IQ motif containing K -3.61252
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -3.60922
RSRC1 arginine/serine-rich coiled-coil 1 -3.60442
DHDDS dehydrodolichyl diphosphate synthase -3.60157
TMEM51 transmembrane protein 51 -3.59305
SEC31B SEC31 homolog B (S. cerevisiae) -3.5707
C1ORF54 chromosome 1 open reading frame 54 -3.5693
APOA2 apolipoprotein A-II -3.55285
IGLL1 immunoglobulin lambda-like polypeptide 1 -3.54821
WDFY3 WD repeat and FYVE domain containing 3 -3.54802
RALY RALY heterogeneous nuclear ribonucleoprotein -3.54623
CXCL2 chemokine (C-X-C motif) ligand 2 -3.54462
SRPRB signal recognition particle receptor, B subunit -3.53987
JUP junction plakoglobin -3.53849
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -3.53592
ADGRG3 adhesion G protein-coupled receptor G3 -3.53546
PARL presenilin associated, rhomboid-like -3.5248
RUFY3 RUN and FYVE domain containing 3 -3.52042
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) -3.51614
LINC00339 long intergenic non-protein coding RNA 339 -3.51572
AGO3 argonaute RISC catalytic component 3 -3.51416
ELMO3 engulfment and cell motility 3 -3.51012
ARMCX4 armadillo repeat containing, X-linked 4 -3.50896
SERGEF secretion regulating guanine nucleotide exchange factor -3.49486
KIAA0319 KIAA0319 -3.49413
PFN2 profilin 2 -3.48973
CEP104 centrosomal protein 104kDa -3.4889
ZNF93 zinc finger protein 93 -3.48437
ABHD14A abhydrolase domain containing 14A -3.48226
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -3.46108
ERCC1 excision repair cross-complementation group 1 -3.45208
SDC2 syndecan 2 -3.44501
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -3.43933
NUBPL nucleotide binding protein-like -3.43873
FAM13A family with sequence similarity 13, member A -3.42608
OPHN1 oligophrenin 1 -3.42103
RALGDS ral guanine nucleotide dissociation stimulator -3.4184
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa -3.40891
STX8 syntaxin 8 -3.39418
MRAP melanocortin 2 receptor accessory protein -3.38562
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -3.37687
PSD3 pleckstrin and Sec7 domain containing 3 -3.37302
CSF1 colony stimulating factor 1 (macrophage) -3.37299
RGS16 regulator of G-protein signaling 16 -3.36349
CCDC15 coiled-coil domain containing 15 -3.36286
RAB1B RAB1B, member RAS oncogene family -3.36008
PLPBP pyridoxal phosphate binding protein -3.35735
LRRN2 leucine rich repeat neuronal 2 -3.3516
CCL20 chemokine (C-C motif) ligand 20 -3.34957
ZNF148 zinc finger protein 148 -3.34938
PLPP3 phospholipid phosphatase 3 -3.33853
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -3.33793
CXCL8 chemokine (C-X-C motif) ligand 8 -3.33518
PTK2B protein tyrosine kinase 2 beta -3.33359
DSN1 DSN1, MIS12 kinetochore complex component -3.33238
S100A14 S100 calcium binding protein A14 -3.33176
SCIN scinderin -3.32979
DCP1A decapping mRNA 1A -3.32073
EIF2D eukaryotic translation initiation factor 2D -3.3195
ALPK3 alpha-kinase 3 -3.31373
ABHD2 abhydrolase domain containing 2 -3.31302
GULP1 GULP, engulfment adaptor PTB domain containing 1 -3.30946
LLGL2 lethal giant larvae homolog 2 (Drosophila) -3.30821
ICAM1 intercellular adhesion molecule 1 -3.30807
GPR162 G protein-coupled receptor 162 -3.30284
FAM193B family with sequence similarity 193, member B -3.30136
FOS FBJ murine osteosarcoma viral oncogene homolog -3.2813
PKDREJ polycystin (PKD) family receptor for egg jelly -3.2783
ZNF124 zinc finger protein 124 -3.27713
IGSF6 immunoglobulin superfamily, member 6 -3.27698
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -3.27562
SOBP sine oculis binding protein homolog (Drosophila) -3.27391
VSIG10 V-set and immunoglobulin domain containing 10 -3.27368
ERLIN2 ER lipid raft associated 2 -3.26124
EFNB2 ephrin-B2 -3.25588
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -3.25507
CD68 CD68 molecule -3.24815
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -3.24529
RRAGC Ras-related GTP binding C -3.24362
ABI3BP ABI family, member 3 (NESH) binding protein -3.23731
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 -3.23698
IFT38 intraflagellar transport 38 -3.23183
ASB13 ankyrin repeat and SOCS box containing 13 -3.22848
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -3.22339
C3AR1 complement component 3a receptor 1 -3.2227
ZNF580 zinc finger protein 580 -3.22171
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.21284
LZTFL1 leucine zipper transcription factor-like 1 -3.20932
SCAND1 SCAN domain containing 1 -3.2061
ARID5A AT rich interactive domain 5A (MRF1-like) -3.20382
ADAMDEC1 ADAM-like, decysin 1 -3.20373
CD82 CD82 molecule -3.2022
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -3.20215
SYT17 synaptotagmin XVII -3.20194
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 -3.19893
SLC66A2 solute carrier family 66 member 2 -3.19645
SLC44A1 solute carrier family 44 (choline transporter), member 1 -3.18509
CLSTN3 calsyntenin 3 -3.18475
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -3.18473
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -3.18375
RAB20 RAB20, member RAS oncogene family -3.18009
FOLR3 folate receptor 3 (gamma) -3.1772
CDK14 cyclin-dependent kinase 14 -3.17186
AIP aryl hydrocarbon receptor interacting protein -3.16211
CORO1B coronin, actin binding protein, 1B -3.15913
IFT46 intraflagellar transport 46 -3.15882
SCD5 stearoyl-CoA desaturase 5 -3.1575
ZNF85 zinc finger protein 85 -3.15713
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -3.1456
PFDN5 prefoldin subunit 5 -3.14243
MT1E metallothionein 1E -3.13932
GLA galactosidase, alpha -3.13705
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -3.13487
CNPY4 canopy FGF signaling regulator 4 -3.12582
IFT88 intraflagellar transport 88 -3.12242
RRAGD Ras-related GTP binding D -3.1156
LTK leukocyte receptor tyrosine kinase -3.11295
SPEG SPEG complex locus -3.11269
CLCN4 chloride channel, voltage-sensitive 4 -3.10926
GOLIM4 golgi integral membrane protein 4 -3.10629
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -3.10413
KLF2 Kruppel-like factor 2 -3.09852
CDH22 cadherin 22, type 2 -3.09659
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -3.09228
AAK1 AP2 associated kinase 1 -3.09005
G6PC2 glucose-6-phosphatase, catalytic, 2 -3.0872
ECI1 enoyl-CoA delta isomerase 1 -3.08515
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -3.08022
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding) -3.07937
MRPL4 mitochondrial ribosomal protein L4 -3.07744
KLHL26 kelch-like family member 26 -3.06701
RBM12B RNA binding motif protein 12B -3.06674
ZC3H12A zinc finger CCCH-type containing 12A -3.06655
CCDC81 coiled-coil domain containing 81 -3.06593
ARMCX6 armadillo repeat containing, X-linked 6 -3.06059
TMEM63A transmembrane protein 63A -3.05932
BMP2K BMP2 inducible kinase -3.05643
FPR1 formyl peptide receptor 1 -3.0555
MMP8 matrix metallopeptidase 8 -3.0549
C8ORF44 chromosome 8 open reading frame 44 -3.05454
KLF7 Kruppel-like factor 7 (ubiquitous) -3.05326
WWOX WW domain containing oxidoreductase -3.05299
ADGRE2 adhesion G protein-coupled receptor E2 -3.0519
METTL22 methyltransferase like 22 -3.05046
SHBG sex hormone-binding globulin -3.03831
FOXO3 forkhead box O3 -3.03287
SRI sorcin -3.0328
HIP1R huntingtin interacting protein 1 related -3.01895
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -3.01874
LDB1 LIM domain binding 1 -3.01163
H2AX H2A.X variant histone -3.0096
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -3.0088
GRM1 glutamate receptor, metabotropic 1 -3.00705
CPPED1 calcineurin-like phosphoesterase domain containing 1 -3.0041
PLSCR4 phospholipid scramblase 4 -3.00038