clinical modifier Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description This subontology is designed to provide terms to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects. (Human Phenotype Ontology, HP_0012823)
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40 genes associated with the clinical modifier phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
NRXN1 neurexin 1 0.424122
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.413807
MSRB3 methionine sulfoxide reductase B3 0.413807
PTPRD protein tyrosine phosphatase, receptor type, D 0.406588
CADM2 cell adhesion molecule 2 0.406588
SLA Src-like-adaptor 0.406588
FBN2 fibrillin 2 0.402177
GRIK2 glutamate receptor, ionotropic, kainate 2 0.381276
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.376528
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 0.376528
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.367568
LINC00309 long intergenic non-protein coding RNA 309 0.367568
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.367568
NLRP13 NLR family, pyrin domain containing 13 0.367568
CFL1P1 cofilin 1 (non-muscle) pseudogene 1 0.362254
OTOG otogelin 0.358325
TECTB tectorin beta 0.358325
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.358325
CLYBL citrate lyase beta like 0.358325
FLJ41278 uncharacterized LOC400046 0.358325
KRT33A keratin 33A, type I 0.358325
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.355072
DTX4 deltex 4, E3 ubiquitin ligase 0.355072
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 0.352372
MSH3 mutS homolog 3 0.352372
AFAP1 actin filament associated protein 1 0.352372
FBXO42 F-box protein 42 0.352372
MIR205HG MIR205 host gene 0.352372
MTAP methylthioadenosine phosphorylase 0.352372
NPAS2 neuronal PAS domain protein 2 0.350059
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.350059
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.34792
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.34792
KLHL32 kelch-like family member 32 0.34792
SIX6 SIX homeobox 6 0.34792
RNLS renalase, FAD-dependent amine oxidase 0.34792
NLRP11 NLR family, pyrin domain containing 11 0.34792
TCERG1 transcription elongation regulator 1 0.346043
ARHGAP20 Rho GTPase activating protein 20 0.346043
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.346043