cll Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease. (Experimental Factor Ontology, EFO_0000095)
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Genes

190 genes co-occuring with the biological term cll in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACP1 acid phosphatase 1, soluble
ADAM29 ADAM metallopeptidase domain 29
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALB albumin
ANGPT2 angiopoietin 2
ANPEP alanyl (membrane) aminopeptidase
ARHGAP20 Rho GTPase activating protein 20
ATM ATM serine/threonine kinase
AXL AXL receptor tyrosine kinase
B2M beta-2-microglobulin
BAG3 BCL2-associated athanogene 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L12 BCL2-like 12 (proline rich)
BCL6 B-cell CLL/lymphoma 6
BGN biglycan
BTK Bruton agammaglobulinemia tyrosine kinase
CCL11 chemokine (C-C motif) ligand 11
CCL19 chemokine (C-C motif) ligand 19
CCL21 chemokine (C-C motif) ligand 21
CD2 CD2 molecule
CD200 CD200 molecule
CD37 CD37 molecule
CD38 CD38 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD70 CD70 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD83 CD83 molecule
CD84 CD84 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CLLU1 chronic lymphocytic leukemia up-regulated 1
CRY1 cryptochrome circadian clock 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CYLD cylindromatosis (turban tumor syndrome)
CYSLTR1 cysteinyl leukotriene receptor 1
DAPK1 death-associated protein kinase 1
DAXX death-domain associated protein
DCN decorin
DICER1 dicer 1, ribonuclease type III
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPP8 dipeptidyl-peptidase 8
EFNA4 ephrin-A4
ENG endoglin
EPHA10 EPH receptor A10
EPHB6 EPH receptor B6
EPO erythropoietin
ESR2 estrogen receptor 2 (ER beta)
F2R coagulation factor II (thrombin) receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCMR Fc fragment of IgM receptor
FGF2 fibroblast growth factor 2 (basic)
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
FMNL1 formin-like 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GRN granulin
HLA-G major histocompatibility complex, class I, G
HMMR hyaluronan-mediated motility receptor (RHAMM)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFNGR1 interferon gamma receptor 1
IGH immunoglobulin heavy locus
IGHV4-59 immunoglobulin heavy variable 4-59
IGK immunoglobulin kappa locus
IL10 interleukin 10
IL21 interleukin 21
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
IRF4 interferon regulatory factor 4
IRF5 interferon regulatory factor 5
ITCH itchy E3 ubiquitin protein ligase
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB7 integrin, beta 7
KDR kinase insert domain receptor
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LPAR1 lysophosphatidic acid receptor 1
LPAR2 lysophosphatidic acid receptor 2
LPAR3 lysophosphatidic acid receptor 3
LPAR4 lysophosphatidic acid receptor 4
LPAR5 lysophosphatidic acid receptor 5
LPL lipoprotein lipase
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MCL1 myeloid cell leukemia 1
MIR106B microRNA 106b
MIR125A microRNA 125a
MIR155 microRNA 155
MIR15A microRNA 15a
MIR16-1 microRNA 16-1
MIR17 microRNA 17
MIR22 microRNA 22
MIR29A microRNA 29a
MIR29B1 microRNA 29b-1
MIR29C microRNA 29c
MIR34A microRNA 34a
MIR650 microRNA 650
MKI67 marker of proliferation Ki-67
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH9 myosin, heavy chain 9, non-muscle
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOTCH1 notch 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARP1 poly (ADP-ribose) polymerase 1
PDCD1 programmed cell death 1
PDE7B phosphodiesterase 7B
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRAME preferentially expressed antigen in melanoma
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKCB protein kinase C, beta
PRKCH protein kinase C, eta
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAD51 RAD51 recombinase
RAD52 RAD52 homolog (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHD Rh blood group, D antigen
RHOH ras homolog family member H
ROR1 receptor tyrosine kinase-like orphan receptor 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFRP1 secreted frizzled-related protein 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SMAD7 SMAD family member 7
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYK spleen tyrosine kinase
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TCF3 transcription factor 3
TCL1A T-cell leukemia/lymphoma 1A
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TFRC transferrin receptor
THBS1 thrombospondin 1
TLR7 toll-like receptor 7
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
TP73 tumor protein p73
TPO thyroid peroxidase
TRIP10 thyroid hormone receptor interactor 10
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WNT10A wingless-type MMTV integration site family, member 10A
WNT16 wingless-type MMTV integration site family, member 16
WNT3 wingless-type MMTV integration site family, member 3
WNT4 wingless-type MMTV integration site family, member 4
WNT5B wingless-type MMTV integration site family, member 5B
WNT7B wingless-type MMTV integration site family, member 7B
WNT9A wingless-type MMTV integration site family, member 9A
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa