clock Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description clock circadian regulator|The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 9575)
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Genes

75 genes co-occuring with the biological term clock in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADORA2A adenosine A2a receptor
AHR aryl hydrocarbon receptor
AHRR aryl-hydrocarbon receptor repressor
ANGPTL2 angiopoietin-like 2
AQP3 aquaporin 3 (Gill blood group)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATG14 autophagy related 14
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CDK5 cyclin-dependent kinase 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLOCK clock circadian regulator
COMT catechol-O-methyltransferase
CRTC1 CREB regulated transcription coactivator 1
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CSNK1A1 casein kinase 1, alpha 1
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DBP D site of albumin promoter (albumin D-box) binding protein
DRD2 dopamine receptor D2
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ERN1 endoplasmic reticulum to nucleus signaling 1
ESR1 estrogen receptor 1
FBXL3 F-box and leucine-rich repeat protein 3
FGF21 fibroblast growth factor 21
FGF8 fibroblast growth factor 8 (androgen-induced)
FOXO1 forkhead box O1
GADD45A growth arrest and DNA-damage-inducible, alpha
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HAT1 histone acetyltransferase 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HUS1 HUS1 checkpoint homolog (S. pombe)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IMMT inner membrane protein, mitochondrial
KAT5 K(lysine) acetyltransferase 5
KRAS Kirsten rat sarcoma viral oncogene homolog
MAP2K7 mitogen-activated protein kinase kinase 7
MATR3 matrin 3
METTL3 methyltransferase like 3
MIR142 microRNA 142
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NOX4 NADPH oxidase 4
NPAS2 neuronal PAS domain protein 2
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
PEBP1 phosphatidylethanolamine binding protein 1
PER1 period circadian clock 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PHB2 prohibitin 2
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPP5C protein phosphatase 5, catalytic subunit
RAI1 retinoic acid induced 1
RASD1 RAS, dexamethasone-induced 1
RB1 retinoblastoma 1
RBM4 RNA binding motif protein 4
RORA RAR-related orphan receptor A
RPSA ribosomal protein SA
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT1 sirtuin 1
SUMO1 small ubiquitin-like modifier 1
TGFB2 transforming growth factor, beta 2
THBD thrombomodulin
THPO thrombopoietin
TNF tumor necrosis factor
XPA xeroderma pigmentosum, complementation group A