clomifene-1269 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the clomifene-1269 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADAM10 ADAM metallopeptidase domain 10
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARL4C ADP-ribosylation factor-like 4C
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASXL1 additional sex combs like transcriptional regulator 1
ATP11A ATPase, class VI, type 11A
ATP13A3 ATPase type 13A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BACE1 beta-site APP-cleaving enzyme 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C16ORF59 chromosome 16 open reading frame 59
CAPN5 calpain 5
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD46 CD46 molecule, complement regulatory protein
CDC14A cell division cycle 14A
CRAT carnitine O-acetyltransferase
CYB561 cytochrome b561
CYBB cytochrome b-245, beta polypeptide
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DTNA dystrobrevin, alpha
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM49A family with sequence similarity 49, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXJ3 forkhead box J3
FYB FYN binding protein
GK glycerol kinase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPATCH3 G patch domain containing 3
GTF2I general transcription factor IIi
GTSE1 G-2 and S-phase expressed 1
HIST1H3H histone cluster 1, H3h
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IL1RAP interleukin 1 receptor accessory protein
INO80D INO80 complex subunit D
ITM2B integral membrane protein 2B
KIAA0754 KIAA0754
KIF1A kinesin family member 1A
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLF3 Kruppel-like factor 3 (basic)
KPNA5 karyopherin alpha 5 (importin alpha 6)
LIG4 ligase IV, DNA, ATP-dependent
LINC00094 long intergenic non-protein coding RNA 94
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
LYST lysosomal trafficking regulator
MAPK14 mitogen-activated protein kinase 14
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MINK1 misshapen-like kinase 1
MOCS3 molybdenum cofactor synthesis 3
MX1 MX dynamin-like GTPase 1
NCOA2 nuclear receptor coactivator 2
NEK1 NIMA-related kinase 1
NEK2 NIMA-related kinase 2
NEU3 sialidase 3 (membrane sialidase)
PDE4B phosphodiesterase 4B, cAMP-specific
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLD1 phospholipase D1, phosphatidylcholine-specific
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTAFR platelet-activating factor receptor
QKI QKI, KH domain containing, RNA binding
RAB23 RAB23, member RAS oncogene family
RFK riboflavin kinase
RRBP1 ribosome binding protein 1
SCAMP1 secretory carrier membrane protein 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SMAD3 SMAD family member 3
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
STX16 syntaxin 16
STX3 syntaxin 3
TFG TRK-fused gene
TGDS TDP-glucose 4,6-dehydratase
TLE4 transducin-like enhancer of split 4
TMEM63A transmembrane protein 63A
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSNAXIP1 translin-associated factor X interacting protein 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
VDAC3 voltage-dependent anion channel 3
WDTC1 WD and tetratricopeptide repeats 1
WSB1 WD repeat and SOCS box containing 1
ZBTB6 zinc finger and BTB domain containing 6
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACVR2B activin A receptor, type IIB
ANAPC2 anaphase promoting complex subunit 2
ANPEP alanyl (membrane) aminopeptidase
ATG9A autophagy related 9A
AZU1 azurocidin 1
BAK1 BCL2-antagonist/killer 1
BBC3 BCL2 binding component 3
BRMS1 breast cancer metastasis suppressor 1
C11ORF68 chromosome 11 open reading frame 68
C2CD2 C2 calcium-dependent domain containing 2
C4ORF29 chromosome 4 open reading frame 29
CAMTA2 calmodulin binding transcription activator 2
CARM1 coactivator-associated arginine methyltransferase 1
CD151 CD151 molecule (Raph blood group)
CDK3 cyclin-dependent kinase 3
CEL carboxyl ester lipase
CEP170B centrosomal protein 170B
CFL1 cofilin 1 (non-muscle)
CFP complement factor properdin
CHMP1A charged multivesicular body protein 1A
CIDEB cell death-inducing DFFA-like effector b
CIR1 corepressor interacting with RBPJ, 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CORO7 coronin 7
CPNE1 copine I
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56
DVL1 dishevelled segment polarity protein 1
EGR2 early growth response 2
EGR3 early growth response 3
ERCC2 excision repair cross-complementation group 2
FAM127A family with sequence similarity 127, member A
FBRS fibrosin
FBXL15 F-box and leucine-rich repeat protein 15
FES FES proto-oncogene, tyrosine kinase
FKBP14 FK506 binding protein 14, 22 kDa
FKBP2 FK506 binding protein 2, 13kDa
GMEB1 glucocorticoid modulatory element binding protein 1
GRWD1 glutamate-rich WD repeat containing 1
HP haptoglobin
JUNB jun B proto-oncogene
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCTD13 potassium channel tetramerization domain containing 13
KIAA0556 KIAA0556
KIF3B kinesin family member 3B
KLHL21 kelch-like family member 21
KPTN kaptin (actin binding protein)
LIN37 lin-37 DREAM MuvB core complex component
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC42 leucine rich repeat containing 42
LSP1 lymphocyte-specific protein 1
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MGMT O-6-methylguanine-DNA methyltransferase
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NDE1 nudE neurodevelopment protein 1
NRBP1 nuclear receptor binding protein 1
NRGN neurogranin (protein kinase C substrate, RC3)
NTSR1 neurotensin receptor 1 (high affinity)
ORAI3 ORAI calcium release-activated calcium modulator 3
PBX3 pre-B-cell leukemia homeobox 3
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNMA1 paraneoplastic Ma antigen 1
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
RBM6 RNA binding motif protein 6
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCAMP4 secretory carrier membrane protein 4
SH3GL1 SH3-domain GRB2-like 1
SKI SKI proto-oncogene
SLC22A18 solute carrier family 22, member 18
SPON2 spondin 2, extracellular matrix protein
TBX19 T-box 19
TET3 tet methylcytosine dioxygenase 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM7SF3 transmembrane 7 superfamily member 3
TMEM11 transmembrane protein 11
TMEM160 transmembrane protein 160
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNNT1 troponin T type 1 (skeletal, slow)
TRIM26 tripartite motif containing 26
TRIM28 tripartite motif containing 28
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UBQLN4 ubiquilin 4
USB1 U6 snRNA biogenesis 1
VILL villin-like
WBSCR16 Williams-Beuren syndrome chromosome region 16
ZC3H12A zinc finger CCCH-type containing 12A
ZNF345 zinc finger protein 345
ZNF606 zinc finger protein 606
ZNF669 zinc finger protein 669
ZNF787 zinc finger protein 787
ZNF862 zinc finger protein 862