clomifene-2624 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the clomifene-2624 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACPP acid phosphatase, prostate
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATF3 activating transcription factor 3
AVPR1A arginine vasopressin receptor 1A
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C11ORF21 chromosome 11 open reading frame 21
C17ORF59 chromosome 17 open reading frame 59
CA4 carbonic anhydrase IV
CREBBP CREB binding protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNAL4 dynein, axonemal, light chain 4
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EHD2 EH-domain containing 2
EPHB2 EPH receptor B2
EXOC7 exocyst complex component 7
FAM214B family with sequence similarity 214, member B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXG1 forkhead box G1
FOXO4 forkhead box O4
FRMD1 FERM domain containing 1
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
FXYD5 FXYD domain containing ion transport regulator 5
GLB1L galactosidase, beta 1-like
HDAC4 histone deacetylase 4
HDAC7 histone deacetylase 7
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2BC histone cluster 1, H2bc
HMOX1 heme oxygenase 1
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
ICAM1 intercellular adhesion molecule 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNA10 interferon, alpha 10
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IQSEC2 IQ motif and Sec7 domain 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KDM4C lysine (K)-specific demethylase 4C
KIAA0319L KIAA0319-like
KLK1 kallikrein 1
KREMEN2 kringle containing transmembrane protein 2
LAMC2 laminin, gamma 2
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LTB lymphotoxin beta (TNF superfamily, member 3)
LTB4R leukotriene B4 receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MED28 mediator complex subunit 28
MKL1 megakaryoblastic leukemia (translocation) 1
MPL MPL proto-oncogene, thrombopoietin receptor
MRC2 mannose receptor, C type 2
MT1F metallothionein 1F
MT1X metallothionein 1X
NCOA2 nuclear receptor coactivator 2
NDP Norrie disease (pseudoglioma)
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NPPA natriuretic peptide A
NR6A1 nuclear receptor subfamily 6, group A, member 1
OSBPL10 oxysterol binding protein-like 10
PCNXL2 pecanex-like 2 (Drosophila)
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRN protein tyrosine phosphatase, receptor type, N
PTPRU protein tyrosine phosphatase, receptor type, U
RIMS2 regulating synaptic membrane exocytosis 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
S100A11 S100 calcium binding protein A11
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIRT5 sirtuin 5
SLAMF8 SLAM family member 8
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX2 SRY (sex determining region Y)-box 2
SRCAP Snf2-related CREBBP activator protein
STIM1 stromal interaction molecule 1
TAZ tafazzin
TLR2 toll-like receptor 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM242 transmembrane protein 242
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
UPK3A uroplakin 3A
WDR78 WD repeat domain 78
YIPF2 Yip1 domain family, member 2
YPEL1 yippee-like 1 (Drosophila)
ZCCHC24 zinc finger, CCHC domain containing 24
ZFYVE9 zinc finger, FYVE domain containing 9

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABT1 activator of basal transcription 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
C16ORF59 chromosome 16 open reading frame 59
C19ORF73 chromosome 19 open reading frame 73
C22ORF46 chromosome 22 open reading frame 46
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CCP110 centriolar coiled coil protein 110kDa
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK3 cyclin-dependent kinase 3
CIDEC cell death-inducing DFFA-like effector c
CISH cytokine inducible SH2-containing protein
CNGB3 cyclic nucleotide gated channel beta 3
CRABP1 cellular retinoic acid binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DEAF1 DEAF1 transcription factor
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
EXOC5 exocyst complex component 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM86C1 family with sequence similarity 86, member C1
FKBP5 FK506 binding protein 5
FMO4 flavin containing monooxygenase 4
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAMT guanidinoacetate N-methyltransferase
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GID4 GID complex subunit 4
GJA1 gap junction protein, alpha 1, 43kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
HCFC2 host cell factor C2
HIST1H2AI histone cluster 1, H2ai
IPO8 importin 8
KLF3 Kruppel-like factor 3 (basic)
KRI1 KRI1 homolog (S. cerevisiae)
LIG4 ligase IV, DNA, ATP-dependent
LOC100287590 uncharacterized LOC100287590
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC42 leucine rich repeat containing 42
LY6D lymphocyte antigen 6 complex, locus D
MAGEH1 melanoma antigen family H1
METTL16 methyltransferase like 16
METTL8 methyltransferase like 8
MIS18BP1 MIS18 binding protein 1
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPM3 nucleophosmin/nucleoplasmin 3
NPY5R neuropeptide Y receptor Y5
OSGEP O-sialoglycoprotein endopeptidase
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PDZD8 PDZ domain containing 8
PEX11A peroxisomal biogenesis factor 11 alpha
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PMCH pro-melanin-concentrating hormone
POLH polymerase (DNA directed), eta
POLL polymerase (DNA directed), lambda
PPAN peter pan homolog (Drosophila)
PRICKLE3 prickle homolog 3 (Drosophila)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTDSS2 phosphatidylserine synthase 2
PYCRL pyrroline-5-carboxylate reductase-like
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RAB5C RAB5C, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RCL1 RNA terminal phosphate cyclase-like 1
RNF126P1 ring finger protein 126 pseudogene 1
RPAP1 RNA polymerase II associated protein 1
SCD5 stearoyl-CoA desaturase 5
SGK1 serum/glucocorticoid regulated kinase 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIAH2 siah E3 ubiquitin protein ligase 2
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SNAI2 snail family zinc finger 2
SNHG3 small nucleolar RNA host gene 3
SOX3 SRY (sex determining region Y)-box 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TMEM104 transmembrane protein 104
TMEM180 transmembrane protein 180
TMPRSS3 transmembrane protease, serine 3
TPRA1 transmembrane protein, adipocyte asscociated 1
TRABD TraB domain containing
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBG2 tubulin, gamma 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP20 ubiquitin specific peptidase 20
WDR19 WD repeat domain 19
WDR4 WD repeat domain 4
WRN Werner syndrome, RecQ helicase-like
ZNF281 zinc finger protein 281
ZNF324 zinc finger protein 324
ZNF668 zinc finger protein 668
ZNF675 zinc finger protein 675