clomipramine-3182 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the clomipramine-3182 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASKIN2 CASK interacting protein 2
CD47 CD47 molecule
CDC14B cell division cycle 14B
CDK13 cyclin-dependent kinase 13
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CES1 carboxylesterase 1
CHN2 chimerin 2
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CPZ carboxypeptidase Z
CRHR2 corticotropin releasing hormone receptor 2
CRISP2 cysteine-rich secretory protein 2
CTAG2 cancer/testis antigen 2
CXCL13 chemokine (C-X-C motif) ligand 13
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DIO2 deiodinase, iodothyronine, type II
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
DUSP6 dual specificity phosphatase 6
EFCAB6 EF-hand calcium binding domain 6
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EML2 echinoderm microtubule associated protein like 2
EPHB2 EPH receptor B2
FAM65B family with sequence similarity 65, member B
FBXO40 F-box protein 40
FRMD4B FERM domain containing 4B
GAL3ST4 galactose-3-O-sulfotransferase 4
GIF gastric intrinsic factor (vitamin B synthesis)
GJA9 gap junction protein, alpha 9, 59kDa
GRM3 glutamate receptor, metabotropic 3
GRPR gastrin-releasing peptide receptor
GSK3A glycogen synthase kinase 3 alpha
GYPB glycophorin B (MNS blood group)
HIST1H2AK histone cluster 1, H2ak
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICOS inducible T-cell co-stimulator
IL2RA interleukin 2 receptor, alpha
IQCK IQ motif containing K
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
LIF leukemia inhibitory factor
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MAP1B microtubule-associated protein 1B
MAST2 microtubule associated serine/threonine kinase 2
MATN3 matrilin 3
MMP3 matrix metallopeptidase 3
MTAP methylthioadenosine phosphorylase
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYOD1 myogenic differentiation 1
MYOF myoferlin
MYT1 myelin transcription factor 1
N4BP2L1 NEDD4 binding protein 2-like 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRXN2 neurexin 2
NT5M 5',3'-nucleotidase, mitochondrial
OR2H1 olfactory receptor, family 2, subfamily H, member 1
PCDHGA3 protocadherin gamma subfamily A, 3
PHOX2B paired-like homeobox 2b
PIAS2 protein inhibitor of activated STAT, 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PML promyelocytic leukemia
POU2F2 POU class 2 homeobox 2
POU3F2 POU class 3 homeobox 2
PRAMEF11 PRAME family member 11
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTN pleiotrophin
RHBG Rh family, B glycoprotein (gene/pseudogene)
RPL35A ribosomal protein L35a
SCN2B sodium channel, voltage gated, type II beta subunit
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A30 solute carrier family 25, member 30
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SOX10 SRY (sex determining region Y)-box 10
SQSTM1 sequestosome 1
STRN striatin, calmodulin binding protein
SVIL supervillin
TDRKH tudor and KH domain containing
THBD thrombomodulin
TMEM63A transmembrane protein 63A
TRD T cell receptor delta locus
TYRO3 TYRO3 protein tyrosine kinase
UHRF1BP1L UHRF1 binding protein 1-like
USP29 ubiquitin specific peptidase 29
VCX2 variable charge, X-linked 2
WDR4 WD repeat domain 4
ZBTB20 zinc finger and BTB domain containing 20
ZNF440 zinc finger protein 440
ZNF45 zinc finger protein 45
ZNF76 zinc finger protein 76
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
C17ORF80 chromosome 17 open reading frame 80
C5 complement component 5
CAMK1 calcium/calmodulin-dependent protein kinase I
CAPN15 calpain 15
CCNO cyclin O
CCP110 centriolar coiled coil protein 110kDa
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD53 CD53 molecule
CHRM3 cholinergic receptor, muscarinic 3
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLCN6 chloride channel, voltage-sensitive 6
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
DCAF13 DDB1 and CUL4 associated factor 13
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5A2 eukaryotic translation initiation factor 5A2
ELP6 elongator acetyltransferase complex subunit 6
FAM114A2 family with sequence similarity 114, member A2
FBXO46 F-box protein 46
FGF23 fibroblast growth factor 23
FPGS folylpolyglutamate synthase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GMPR guanosine monophosphate reductase
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
ICK intestinal cell (MAK-like) kinase
IFT54 intraflagellar transport 54
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KRT13 keratin 13, type I
LDHB lactate dehydrogenase B
LIN7B lin-7 homolog B (C. elegans)
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC37A3 leucine rich repeat containing 37, member A3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYZ lysozyme
MBTD1 mbt domain containing 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MUC3A mucin 3A, cell surface associated
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPIPB3 nuclear pore complex interacting protein family, member B3
NSD1 nuclear receptor binding SET domain protein 1
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NXPH4 neurexophilin 4
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OVGP1 oviductal glycoprotein 1, 120kDa
PC pyruvate carboxylase
PDZK1 PDZ domain containing 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRR15L proline rich 15-like
PTK6 protein tyrosine kinase 6
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC3 syndecan 3
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFT2D2 SFT2 domain containing 2
SIRT6 sirtuin 6
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SPAG4 sperm associated antigen 4
SPIDR scaffolding protein involved in DNA repair
SREK1IP1 SREK1-interacting protein 1
SRGN serglycin
ST5 suppression of tumorigenicity 5
SYCP2 synaptonemal complex protein 2
SYT17 synaptotagmin XVII
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TET3 tet methylcytosine dioxygenase 3
THRAP3 thyroid hormone receptor associated protein 3
TIGD6 tigger transposable element derived 6
TMEM159 transmembrane protein 159
TMEM180 transmembrane protein 180
TMEM62 transmembrane protein 62
TNS2 tensin 2
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSPYL2 TSPY-like 2
UPK3B uroplakin 3B
WDR25 WD repeat domain 25
WDR91 WD repeat domain 91
WNT10B wingless-type MMTV integration site family, member 10B
ZBTB25 zinc finger and BTB domain containing 25
ZBTB6 zinc finger and BTB domain containing 6
ZNF16 zinc finger protein 16
ZNF227 zinc finger protein 227
ZNF365 zinc finger protein 365
ZNF442 zinc finger protein 442
ZNF778 zinc finger protein 778