clonidine-1555 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the clonidine-1555 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACVRL1 activin A receptor type II-like 1
ADM adrenomedullin
ANXA1 annexin A1
ANXA2 annexin A2
ANXA2P2 annexin A2 pseudogene 2
ARG1 arginase 1
ARHGAP33 Rho GTPase activating protein 33
ARRB2 arrestin, beta 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AXL AXL receptor tyrosine kinase
BTG1 B-cell translocation gene 1, anti-proliferative
CCL20 chemokine (C-C motif) ligand 20
CD38 CD38 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHN2 chimerin 2
CLDN6 claudin 6
CTSB cathepsin B
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DOCK4 dedicator of cytokinesis 4
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FAM105A family with sequence similarity 105, member A
FAM111A family with sequence similarity 111, member A
FAM13A family with sequence similarity 13, member A
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FCMR Fc fragment of IgM receptor
FKBP9 FK506 binding protein 9, 63 kDa
FTH1 ferritin, heavy polypeptide 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GAB2 GRB2-associated binding protein 2
GAS7 growth arrest-specific 7
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPC1 glypican 1
GPR183 G protein-coupled receptor 183
GSK3A glycogen synthase kinase 3 alpha
HDAC5 histone deacetylase 5
HLA-E major histocompatibility complex, class I, E
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IL10RA interleukin 10 receptor, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL24 interleukin 24
JUN jun proto-oncogene
KYNU kynureninase
LPP LIM domain containing preferred translocation partner in lipoma
NCF2 neutrophil cytosolic factor 2
NCOA3 nuclear receptor coactivator 3
NDRG2 NDRG family member 2
NINJ1 ninjurin 1
NIPAL2 NIPA-like domain containing 2
NOP16 NOP16 nucleolar protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLSCR1 phospholipid scramblase 1
PNOC prepronociceptin
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRE protein tyrosine phosphatase, receptor type, E
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASAL1 RAS protein activator like 1 (GAP1 like)
RBM47 RNA binding motif protein 47
RECQL4 RecQ protein-like 4
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RGS16 regulator of G-protein signaling 16
RIN3 Ras and Rab interactor 3
RNASE6 ribonuclease, RNase A family, k6
SAG S-antigen; retina and pineal gland (arrestin)
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SGK1 serum/glucocorticoid regulated kinase 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SMAD3 SMAD family member 3
SMOX spermine oxidase
SPTAN1 spectrin, alpha, non-erythrocytic 1
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPST1 tyrosylprotein sulfotransferase 1
TREM1 triggering receptor expressed on myeloid cells 1
USF2 upstream transcription factor 2, c-fos interacting

decreased expression

Symbol Name
AATF apoptosis antagonizing transcription factor
ABT1 activator of basal transcription 1
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ADCK3 aarF domain containing kinase 3
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALG3 ALG3, alpha-1,3- mannosyltransferase
ASB13 ankyrin repeat and SOCS box containing 13
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
C10ORF2 chromosome 10 open reading frame 2
C12ORF29 chromosome 12 open reading frame 29
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CBR1 carbonyl reductase 1
CD3EAP CD3e molecule, epsilon associated protein
CDK4 cyclin-dependent kinase 4
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
COA7 cytochrome c oxidase assembly factor 7 (putative)
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EBNA1BP2 EBNA1 binding protein 2
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENDOG endonuclease G
ENOPH1 enolase-phosphatase 1
ERMP1 endoplasmic reticulum metallopeptidase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM189B family with sequence similarity 189, member B
FAM222B family with sequence similarity 222, member B
FAR2 fatty acyl CoA reductase 2
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FKBP4 FK506 binding protein 4, 59kDa
FLT3 fms-related tyrosine kinase 3
FXN frataxin
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
GTPBP6 GTP binding protein 6 (putative)
GUSBP3 glucuronidase, beta pseudogene 3
HDAC9 histone deacetylase 9
HIRA histone cell cycle regulator
HSPH1 heat shock 105kDa/110kDa protein 1
ISOC2 isochorismatase domain containing 2
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KAT2A K(lysine) acetyltransferase 2A
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA0020 KIAA0020
LAMP5 lysosomal-associated membrane protein family, member 5
LAS1L LAS1-like (S. cerevisiae)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MATK megakaryocyte-associated tyrosine kinase
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MRPS34 mitochondrial ribosomal protein S34
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NAT10 N-acetyltransferase 10 (GCN5-related)
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NIP7 NIP7, nucleolar pre-rRNA processing protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NVL nuclear VCP-like
ORC3 origin recognition complex, subunit 3
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PFAS phosphoribosylformylglycinamidine synthase
PFDN2 prefoldin subunit 2
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRMT1 protein arginine methyltransferase 1
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PUS7 pseudouridylate synthase 7 (putative)
RAB1B RAB1B, member RAS oncogene family
RABEPK Rab9 effector protein with kelch motifs
RBM28 RNA binding motif protein 28
REXO2 RNA exonuclease 2
RPIA ribose 5-phosphate isomerase A
RRP1 ribosomal RNA processing 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SEH1L SEH1-like (S. cerevisiae)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNX17 sorting nexin 17
STIP1 stress-induced phosphoprotein 1
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TSLIG3A tRNA splicing ligase complex subunit 3A
TTC27 tetratricopeptide repeat domain 27
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR18 WD repeat domain 18
WDR3 WD repeat domain 3
ZBTB24 zinc finger and BTB domain containing 24
ZPR1 ZPR1 zinc finger