clonidine-4478 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the clonidine-4478 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRE2 adhesion G protein-coupled receptor E2
ALPK1 alpha-kinase 1
ANP32A-IT1 ANP32A intronic transcript 1
APC adenomatous polyposis coli
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
C7ORF69 chromosome 7 open reading frame 69
C9ORF9 chromosome 9 open reading frame 9
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC121 coiled-coil domain containing 121
CCDC181 coiled-coil domain containing 181
CD52 CD52 molecule
CDK13 cyclin-dependent kinase 13
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CHAT choline O-acetyltransferase
CLEC4A C-type lectin domain family 4, member A
COL5A1 collagen, type V, alpha 1
COL8A1 collagen, type VIII, alpha 1
CSHL1 chorionic somatomammotropin hormone-like 1
CXORF21 chromosome X open reading frame 21
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DSPP dentin sialophosphoprotein
EBF2 early B-cell factor 2
ECE1 endothelin converting enzyme 1
EDNRA endothelin receptor type A
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM63B family with sequence similarity 63, member B
FGFR2 fibroblast growth factor receptor 2
FLJ21369 uncharacterized protein FLJ21369
FLT3LG fms-related tyrosine kinase 3 ligand
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FYB FYN binding protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GPC3 glypican 3
GRM1 glutamate receptor, metabotropic 1
GRM8 glutamate receptor, metabotropic 8
HCRP1 hepatocellular carcinoma-related HCRP1
HR hair growth associated
HRH2 histamine receptor H2
HSPG2 heparan sulfate proteoglycan 2
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGHA1 immunoglobulin heavy constant alpha 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KLHL22 kelch-like family member 22
KSR1 kinase suppressor of ras 1
LAMC3 laminin, gamma 3
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LRP1 low density lipoprotein receptor-related protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFGE8 milk fat globule-EGF factor 8 protein
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MRPS18C mitochondrial ribosomal protein S18C
MTMR7 myotubularin related protein 7
MUC6 mucin 6, oligomeric mucus/gel-forming
NAG18 NAG18 mRNA
NCF4 neutrophil cytosolic factor 4, 40kDa
NCOR2 nuclear receptor corepressor 2
NRP2 neuropilin 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDLIM5 PDZ and LIM domain 5
PICALM phosphatidylinositol binding clathrin assembly protein
PLIN2 perilipin 2
PMFBP1 polyamine modulated factor 1 binding protein 1
POM121 POM121 transmembrane nucleoporin
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBPMS RNA binding protein with multiple splicing
RGS12 regulator of G-protein signaling 12
RPLP2 ribosomal protein, large, P2
RUNX1 runt-related transcription factor 1
SCGB2A2 secretoglobin, family 2A, member 2
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SNN stannin
SP100 SP100 nuclear antigen
SPRR1A small proline-rich protein 1A
SSX1 synovial sarcoma, X breakpoint 1
SULF1 sulfatase 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TRPC4 transient receptor potential cation channel, subfamily C, member 4
VCAN versican
ZSCAN32 zinc finger and SCAN domain containing 32
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRB2 adhesion G protein-coupled receptor B2
AMT aminomethyltransferase
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ASIC3 acid sensing (proton gated) ion channel 3
AURKC aurora kinase C
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BBC3 BCL2 binding component 3
BICC1 BicC family RNA binding protein 1
C14ORF93 chromosome 14 open reading frame 93
C17ORF80 chromosome 17 open reading frame 80
C1ORF105 chromosome 1 open reading frame 105
C1S complement component 1, s subcomponent
C3 complement component 3
CCDC186 coiled-coil domain containing 186
CD101 CD101 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CES3 carboxylesterase 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CPA4 carboxypeptidase A4
DGKE diacylglycerol kinase, epsilon 64kDa
EFNA1 ephrin-A1
EPHA4 EPH receptor A4
EXD3 exonuclease 3'-5' domain containing 3
EXOC6B exocyst complex component 6B
FANCC Fanconi anemia, complementation group C
FBXL15 F-box and leucine-rich repeat protein 15
FBXL7 F-box and leucine-rich repeat protein 7
FKBP1B FK506 binding protein 1B, 12.6 kDa
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HDAC11 histone deacetylase 11
HIST1H2BM histone cluster 1, H2bm
HIST1H4C histone cluster 1, H4c
HIST2H2AA3 histone cluster 2, H2aa3
HMHA1 histocompatibility (minor) HA-1
HOXA6 homeobox A6
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IL17RB interleukin 17 receptor B
IL33 interleukin 33
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA0513 KIAA0513
KRT8P12 keratin 8 pseudogene 12
LMO7 LIM domain 7
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LYRM9 LYR motif containing 9
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MLYCD malonyl-CoA decarboxylase
MUC3A mucin 3A, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYH15 myosin, heavy chain 15
NABP1 nucleic acid binding protein 1
OR1D2 olfactory receptor, family 1, subfamily D, member 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PARP6 poly (ADP-ribose) polymerase family, member 6
PCDHA9 protocadherin alpha 9
PCDHGB5 protocadherin gamma subfamily B, 5
PDZK1 PDZ domain containing 1
POU3F2 POU class 3 homeobox 2
PRPH peripherin
PXMP4 peroxisomal membrane protein 4, 24kDa
RNF122 ring finger protein 122
RPL23AP32 ribosomal protein L23a pseudogene 32
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCD5 stearoyl-CoA desaturase 5
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A9 solute carrier family 12, member 9
SLC22A14 solute carrier family 22, member 14
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLITRK5 SLIT and NTRK-like family, member 5
SLMO1 slowmo homolog 1 (Drosophila)
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPRYD7 SPRY domain containing 7
STARD3 StAR-related lipid transfer (START) domain containing 3
SYNGR3 synaptogyrin 3
TCTN2 tectonic family member 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM132A transmembrane protein 132A
TMEM180 transmembrane protein 180
TMEM19 transmembrane protein 19
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTC26 tetratricopeptide repeat domain 26
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
VWA1 von Willebrand factor A domain containing 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF253 zinc finger protein 253
ZNF480 zinc finger protein 480
ZNF573 zinc finger protein 573
ZNF671 zinc finger protein 671