cloperastine-3608 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the cloperastine-3608 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACPP acid phosphatase, prostate
ADRB3 adrenoceptor beta 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOC1 apolipoprotein C-I
ASCL1 achaete-scute family bHLH transcription factor 1
ATF3 activating transcription factor 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BIRC3 baculoviral IAP repeat containing 3
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CARTPT CART prepropeptide
CCL5 chemokine (C-C motif) ligand 5
CD22 CD22 molecule
CD5 CD5 molecule
CD70 CD70 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD82 CD82 molecule
CIB2 calcium and integrin binding family member 2
CLDN1 claudin 1
COL13A1 collagen, type XIII, alpha 1
CTSO cathepsin O
DAPK2 death-associated protein kinase 2
DDO D-aspartate oxidase
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DNASE2B deoxyribonuclease II beta
DPP4 dipeptidyl-peptidase 4
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EPHB6 EPH receptor B6
ERCC2 excision repair cross-complementation group 2
ETV5 ets variant 5
ETV6 ets variant 6
GEM GTP binding protein overexpressed in skeletal muscle
GGT1 gamma-glutamyltransferase 1
GLRA2 glycine receptor, alpha 2
GP2 glycoprotein 2 (zymogen granule membrane)
HBB hemoglobin, beta
HHIPL2 HHIP-like 2
HPCAL4 hippocalcin like 4
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL1RN interleukin 1 receptor antagonist
IL5RA interleukin 5 receptor, alpha
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
IVL involucrin
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KLF12 Kruppel-like factor 12
LRTM1 leucine-rich repeats and transmembrane domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARK4 MAP/microtubule affinity-regulating kinase 4
MCAM melanoma cell adhesion molecule
MID1 midline 1
MLN motilin
MXRA8 matrix-remodelling associated 8
NCKIPSD NCK interacting protein with SH3 domain
NELL2 NEL-like 2 (chicken)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOV nephroblastoma overexpressed
NR4A1 nuclear receptor subfamily 4, group A, member 1
OASL 2'-5'-oligoadenylate synthetase-like
PALM paralemmin
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRDM12 PR domain containing 12
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSG4 pregnancy specific beta-1-glycoprotein 4
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RARB retinoic acid receptor, beta
RBM48 RNA binding motif protein 48
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND1 Rho family GTPase 1
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1
SCARA3 scavenger receptor class A, member 3
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SOX2 SRY (sex determining region Y)-box 2
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTB spectrin, beta, erythrocytic
SQSTM1 sequestosome 1
SRPK2 SRSF protein kinase 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIM2 tripartite motif containing 2
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TTPA tocopherol (alpha) transfer protein
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
VSX1 visual system homeobox 1
ZBTB17 zinc finger and BTB domain containing 17
ZC2HC1C zinc finger, C2HC-type containing 1C
ZFP64 ZFP64 zinc finger protein

decreased expression

Symbol Name
ACTL8 actin-like 8
AMT aminomethyltransferase
ANKRD36 ankyrin repeat domain 36
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGAP11A Rho GTPase activating protein 11A
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARPIN actin-related protein 2/3 complex inhibitor
ASAP1-IT1 ASAP1 intronic transcript 1
B9D2 B9 protein domain 2
BBS7 Bardet-Biedl syndrome 7
BGLAP bone gamma-carboxyglutamate (gla) protein
BIRC7 baculoviral IAP repeat containing 7
C1ORF35 chromosome 1 open reading frame 35
C2ORF54 chromosome 2 open reading frame 54
C8ORF44 chromosome 8 open reading frame 44
C8ORF60 chromosome 8 open reading frame 60
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALML5 calmodulin-like 5
CCDC85C coiled-coil domain containing 85C
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD302 CD302 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD53 CD53 molecule
CDK6 cyclin-dependent kinase 6
CGREF1 cell growth regulator with EF-hand domain 1
CIDEB cell death-inducing DFFA-like effector b
CLGN calmegin
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CUZD1 CUB and zona pellucida-like domains 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DOK2 docking protein 2, 56kDa
DYSF dysferlin
EFCAB2 EF-hand calcium binding domain 2
ENO2 enolase 2 (gamma, neuronal)
EPN1 epsin 1
EPPK1 epiplakin 1
ERN2 endoplasmic reticulum to nucleus signaling 2
F2R coagulation factor II (thrombin) receptor
FGL1 fibrinogen-like 1
GLDC glycine dehydrogenase (decarboxylating)
GPR21 G protein-coupled receptor 21
GPR27 G protein-coupled receptor 27
GUSBP3 glucuronidase, beta pseudogene 3
HDAC7 histone deacetylase 7
HIST1H4F histone cluster 1, H4f
HMGB3P1 high mobility group box 3 pseudogene 1
HOXA4 homeobox A4
IFNA17 interferon, alpha 17
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KRT9 keratin 9, type I
LEFTY1 left-right determination factor 1
LOXL3 lysyl oxidase-like 3
LRP2 low density lipoprotein receptor-related protein 2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
METTL8 methyltransferase like 8
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
NOL10 nucleolar protein 10
NPFFR1 neuropeptide FF receptor 1
NT5C 5', 3'-nucleotidase, cytosolic
NT5DC3 5'-nucleotidase domain containing 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGB5 protocadherin gamma subfamily B, 5
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCD1 phospholipase C, delta 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R9A protein phosphatase 1, regulatory subunit 9A
RAB3D RAB3D, member RAS oncogene family
RABL3 RAB, member of RAS oncogene family-like 3
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RGS2 regulator of G-protein signaling 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLMO1 slowmo homolog 1 (Drosophila)
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMEM104 transmembrane protein 104
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM180 transmembrane protein 180
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRDMT1 tRNA aspartic acid methyltransferase 1
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UNC93B1 unc-93 homolog B1 (C. elegans)
USB1 U6 snRNA biogenesis 1
USP36 ubiquitin specific peptidase 36
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
YY2 YY2 transcription factor
ZBTB6 zinc finger and BTB domain containing 6
ZNF480 zinc finger protein 480
ZNF484 zinc finger protein 484
ZNF701 zinc finger protein 701
ZNF721 zinc finger protein 721