cloperastine-4732 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the cloperastine-4732 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASIC1 acid sensing (proton gated) ion channel 1
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
ATP10B ATPase, class V, type 10B
BAIAP3 BAI1-associated protein 3
BHLHE40 basic helix-loop-helix family, member e40
BST2 bone marrow stromal cell antigen 2
C4BPA complement component 4 binding protein, alpha
C5AR1 complement component 5a receptor 1
CCDC87 coiled-coil domain containing 87
CCRL2 chemokine (C-C motif) receptor-like 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL9A3 collagen, type IX, alpha 3
CSF1 colony stimulating factor 1 (macrophage)
CXCL8 chemokine (C-X-C motif) ligand 8
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
ENO3 enolase 3 (beta, muscle)
ETV4 ets variant 4
FAM46C family with sequence similarity 46, member C
FBXO4 F-box protein 4
FHL1 four and a half LIM domains 1
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FRMD4B FERM domain containing 4B
FZD5 frizzled class receptor 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H3B histone cluster 1, H3b
HPX hemopexin
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IER2 immediate early response 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
INHBE inhibin, beta E
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LEFTY1 left-right determination factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK7 mitogen-activated protein kinase 7
MARK4 MAP/microtubule affinity-regulating kinase 4
MATN1 matrilin 1, cartilage matrix protein
MT1F metallothionein 1F
MVB12B multivesicular body subunit 12B
N4BP2L2 NEDD4 binding protein 2-like 2
NEB nebulin
NPAS3 neuronal PAS domain protein 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP188 nucleoporin 188kDa
NUP88 nucleoporin 88kDa
OASL 2'-5'-oligoadenylate synthetase-like
OSGIN1 oxidative stress induced growth inhibitor 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHB17P protocadherin beta 17 pseudogene
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHEB Ras homolog enriched in brain
RND1 Rho family GTPase 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SRCAP Snf2-related CREBBP activator protein
TBCD tubulin folding cofactor D
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TSC22D4 TSC22 domain family, member 4
UBE2I ubiquitin-conjugating enzyme E2I
ZNF358 zinc finger protein 358

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTL8 actin-like 8
ALS2CL ALS2 C-terminal like
ANXA2P3 annexin A2 pseudogene 3
APOD apolipoprotein D
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BFSP1 beaded filament structural protein 1, filensin
C2ORF27A chromosome 2 open reading frame 27A
C5ORF45 chromosome 5 open reading frame 45
C6ORF47 chromosome 6 open reading frame 47
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CBR4 carbonyl reductase 4
CCDC69 coiled-coil domain containing 69
CCDC85C coiled-coil domain containing 85C
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CENPO centromere protein O
CORT cortistatin
DMTN dematin actin binding protein
DOCK4 dedicator of cytokinesis 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFL7 EGF-like-domain, multiple 7
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ETNK2 ethanolamine kinase 2
FAM110B family with sequence similarity 110, member B
FAM86C1 family with sequence similarity 86, member C1
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GPR143 G protein-coupled receptor 143
HIRA histone cell cycle regulator
IFT54 intraflagellar transport 54
IRAK4 interleukin-1 receptor-associated kinase 4
KIAA1456 KIAA1456
KREMEN2 kringle containing transmembrane protein 2
LGALS4 lectin, galactoside-binding, soluble, 4
LHX6 LIM homeobox 6
LIN7A lin-7 homolog A (C. elegans)
LMNB1 lamin B1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MBTD1 mbt domain containing 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
METTL8 methyltransferase like 8
MRPS18C mitochondrial ribosomal protein S18C
NIPAL2 NIPA-like domain containing 2
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAQR6 progestin and adipoQ receptor family member VI
PARD6A par-6 family cell polarity regulator alpha
PCDHA6 protocadherin alpha 6
PDE12 phosphodiesterase 12
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDIA3 protein disulfide isomerase family A, member 3
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PER3 period circadian clock 3
PGR progesterone receptor
PLEKHA6 pleckstrin homology domain containing, family A member 6
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POTEKP POTE ankyrin domain family, member K, pseudogene
RAB33B RAB33B, member RAS oncogene family
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RPL23AP32 ribosomal protein L23a pseudogene 32
S100A9 S100 calcium binding protein A9
SAMD9 sterile alpha motif domain containing 9
SCML2 sex comb on midleg-like 2 (Drosophila)
SEC14L2 SEC14-like 2 (S. cerevisiae)
SLC16A6 solute carrier family 16, member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPINK5 serine peptidase inhibitor, Kazal type 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STIM1 stromal interaction molecule 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBX19 T-box 19
TET3 tet methylcytosine dioxygenase 3
THNSL1 threonine synthase-like 1 (S. cerevisiae)
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TLR5 toll-like receptor 5
TMEM121 transmembrane protein 121
TMEM19 transmembrane protein 19
TMEM38B transmembrane protein 38B
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
UBQLN4 ubiquilin 4
UBTD1 ubiquitin domain containing 1
USB1 U6 snRNA biogenesis 1
WDR76 WD repeat domain 76
ZBTB44 zinc finger and BTB domain containing 44
ZBTB6 zinc finger and BTB domain containing 6
ZNF253 zinc finger protein 253
ZNF506 zinc finger protein 506
ZNF778 zinc finger protein 778