cloxacillin-2126 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the cloxacillin-2126 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOE apolipoprotein E
APOM apolipoprotein M
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASAP1-IT1 ASAP1 intronic transcript 1
ASIC1 acid sensing (proton gated) ion channel 1
ASIC3 acid sensing (proton gated) ion channel 3
ATG10 autophagy related 10
AURKA aurora kinase A
BTBD7 BTB (POZ) domain containing 7
C16ORF59 chromosome 16 open reading frame 59
C1ORF95 chromosome 1 open reading frame 95
CACYBP calcyclin binding protein
CDADC1 cytidine and dCMP deaminase domain containing 1
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CISH cytokine inducible SH2-containing protein
CPT1A carnitine palmitoyltransferase 1A (liver)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
EPS8L1 EPS8-like 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ESRRA estrogen-related receptor alpha
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FBXO2 F-box protein 2
FGF1 fibroblast growth factor 1 (acidic)
FURIN furin (paired basic amino acid cleaving enzyme)
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GLS2 glutaminase 2 (liver, mitochondrial)
GREB1L growth regulation by estrogen in breast cancer-like
GRM8 glutamate receptor, metabotropic 8
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HOOK1 hook microtubule-tethering protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL5RA interleukin 5 receptor, alpha
JAK2 Janus kinase 2
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIRREL kin of IRRE like (Drosophila)
LOC100272216 uncharacterized LOC100272216
LRP1 low density lipoprotein receptor-related protein 1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYPD3 LY6/PLAUR domain containing 3
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NOL12 nucleolar protein 12
NOP14-AS1 NOP14 antisense RNA 1
NOP16 NOP16 nucleolar protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PARP6 poly (ADP-ribose) polymerase family, member 6
PARVA parvin, alpha
PBX1 pre-B-cell leukemia homeobox 1
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PDLIM7 PDZ and LIM domain 7 (enigma)
PER3 period circadian clock 3
PEX5 peroxisomal biogenesis factor 5
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKP3 plakophilin 3
PRDM2 PR domain containing 2, with ZNF domain
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRPH peripherin
REST RE1-silencing transcription factor
RGS4 regulator of G-protein signaling 4
RPL10 ribosomal protein L10
SERHL2 serine hydrolase-like 2
SIRT6 sirtuin 6
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMAD3 SMAD family member 3
SMAD5 SMAD family member 5
SMG6 SMG6 nonsense mediated mRNA decay factor
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SP100 SP100 nuclear antigen
SYNE1 spectrin repeat containing, nuclear envelope 1
TPM1 tropomyosin 1 (alpha)
TREX1 three prime repair exonuclease 1
TRIM29 tripartite motif containing 29
VAV3 vav 3 guanine nucleotide exchange factor
VGF VGF nerve growth factor inducible
WDR91 WD repeat domain 91
WNT7A wingless-type MMTV integration site family, member 7A
ZBTB38 zinc finger and BTB domain containing 38
ZBTB43 zinc finger and BTB domain containing 43
ZFHX3 zinc finger homeobox 3
ZMYM5 zinc finger, MYM-type 5
ZNF253 zinc finger protein 253
ZNF358 zinc finger protein 358
ZNF467 zinc finger protein 467
ZNF701 zinc finger protein 701

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ACAD10 acyl-CoA dehydrogenase family, member 10
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACKR3 atypical chemokine receptor 3
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADGRG2 adhesion G protein-coupled receptor G2
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARMC6 armadillo repeat containing 6
ARRB2 arrestin, beta 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BBS7 Bardet-Biedl syndrome 7
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L2 BCL2-like 2
BNC1 basonuclin 1
C6ORF47 chromosome 6 open reading frame 47
CABIN1 calcineurin binding protein 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CBR4 carbonyl reductase 4
CCDC130 coiled-coil domain containing 130
CCNJL cyclin J-like
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD70 CD70 molecule
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDON cell adhesion associated, oncogene regulated
CLDN8 claudin 8
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNOT6 CCR4-NOT transcription complex, subunit 6
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYB5R2 cytochrome b5 reductase 2
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
ECM1 extracellular matrix protein 1
EN1 engrailed homeobox 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM188A family with sequence similarity 188, member A
FBXL15 F-box and leucine-rich repeat protein 15
FPGS folylpolyglutamate synthase
GALK1 galactokinase 1
GPKOW G patch domain and KOW motifs
HMG20A high mobility group 20A
HMGB3P1 high mobility group box 3 pseudogene 1
HOXA1 homeobox A1
ITGA10 integrin, alpha 10
KIAA1107 KIAA1107
KLF3 Kruppel-like factor 3 (basic)
KLHL28 kelch-like family member 28
LRP2 low density lipoprotein receptor-related protein 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCMBP minichromosome maintenance complex binding protein
MCTP1 multiple C2 domains, transmembrane 1
MCTP2 multiple C2 domains, transmembrane 2
MED9 mediator complex subunit 9
MPDU1 mannose-P-dolichol utilization defect 1
MPI mannose phosphate isomerase
MRPL44 mitochondrial ribosomal protein L44
MXD3 MAX dimerization protein 3
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NID2 nidogen 2 (osteonidogen)
NME3 NME/NM23 nucleoside diphosphate kinase 3
NSUN3 NOP2/Sun domain family, member 3
NUP62CL nucleoporin 62kDa C-terminal like
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDGFRL platelet-derived growth factor receptor-like
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
QSER1 glutamine and serine rich 1
RABL6 RAB, member RAS oncogene family-like 6
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RNF167 ring finger protein 167
RNF220 ring finger protein 220
RPUSD2 RNA pseudouridylate synthase domain containing 2
S1PR1 sphingosine-1-phosphate receptor 1
SETD6 SET domain containing 6
SH3BGR SH3 domain binding glutamate-rich protein
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SSNA1 Sjogren syndrome nuclear autoantigen 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TPCN1 two pore segment channel 1
TUBA3C tubulin, alpha 3c
TUBB2B tubulin, beta 2B class IIb
TWISTNB TWIST neighbor
VGLL3 vestigial-like family member 3
WDR18 WD repeat domain 18
WNT5B wingless-type MMTV integration site family, member 5B
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF107 zinc finger protein 107
ZNF137P zinc finger protein 137, pseudogene
ZNF141 zinc finger protein 141
ZNF205 zinc finger protein 205
ZNF254 zinc finger protein 254
ZNHIT2 zinc finger, HIT-type containing 2