clozapine-1289 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the clozapine-1289 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACPP acid phosphatase, prostate
ADRBK2 adrenergic, beta, receptor kinase 2
ANKRD12 ankyrin repeat domain 12
APP amyloid beta (A4) precursor protein
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
BIN1 bridging integrator 1
C16ORF59 chromosome 16 open reading frame 59
CAPN2 calpain 2, (m/II) large subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBX7 chromobox homolog 7
CCDC93 coiled-coil domain containing 93
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK16 cyclin-dependent kinase 16
CDK19 cyclin-dependent kinase 19
CDYL chromodomain protein, Y-like
CELF1 CUGBP, Elav-like family member 1
CLCN5 chloride channel, voltage-sensitive 5
COMT catechol-O-methyltransferase
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNMBP dynamin binding protein
DTNA dystrobrevin, alpha
ELOVL6 ELOVL fatty acid elongase 6
ELP6 elongator acetyltransferase complex subunit 6
ETV5 ets variant 5
EVA1B eva-1 homolog B (C. elegans)
FAM114A1 family with sequence similarity 114, member A1
FANCF Fanconi anemia, complementation group F
FOXJ2 forkhead box J2
GRIK5 glutamate receptor, ionotropic, kainate 5
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1T histone cluster 1, H1t
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HSPA4 heat shock 70kDa protein 4
IL18RAP interleukin 18 receptor accessory protein
KAZN kazrin, periplakin interacting protein
KRIT1 KRIT1, ankyrin repeat containing
LIMS1 LIM and senescent cell antigen-like domains 1
LOC157562 uncharacterized LOC157562
LPIN2 lipin 2
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MEF2A myocyte enhancer factor 2A
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NEK1 NIMA-related kinase 1
NLK nemo-like kinase
NUMA1 nuclear mitotic apparatus protein 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE4DIP phosphodiesterase 4D interacting protein
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCB2 phospholipase C, beta 2
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
POLL polymerase (DNA directed), lambda
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PTAFR platelet-activating factor receptor
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RBKS ribokinase
REPS1 RALBP1 associated Eps domain containing 1
RGS10 regulator of G-protein signaling 10
RRP1B ribosomal RNA processing 1B
SCRN3 secernin 3
SEC24D SEC24 family member D
SGSM3 small G protein signaling modulator 3
SH3BP2 SH3-domain binding protein 2
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SOCS2 suppressor of cytokine signaling 2
SREBF1 sterol regulatory element binding transcription factor 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STXBP6 syntaxin binding protein 6 (amisyn)
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM254 transmembrane protein 254
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52 tumor protein D52
TRAM2 translocation associated membrane protein 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WBP4 WW domain binding protein 4
WDR44 WD repeat domain 44
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBED4 zinc finger, BED-type containing 4
ZBTB40 zinc finger and BTB domain containing 40
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF174 zinc finger protein 174
ZNF839 zinc finger protein 839

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
ANKHD1 ankyrin repeat and KH domain containing 1
ANO10 anoctamin 10
APOL6 apolipoprotein L, 6
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARMC6 armadillo repeat containing 6
ASGR2 asialoglycoprotein receptor 2
BATF basic leucine zipper transcription factor, ATF-like
BSPRY B-box and SPRY domain containing
BST1 bone marrow stromal cell antigen 1
C1ORF35 chromosome 1 open reading frame 35
C1ORF56 chromosome 1 open reading frame 56
C5AR1 complement component 5a receptor 1
C5ORF45 chromosome 5 open reading frame 45
CD38 CD38 molecule
CEP170B centrosomal protein 170B
CEP97 centrosomal protein 97kDa
CPTP ceramide-1-phosphate transfer protein
CTNNBIP1 catenin, beta interacting protein 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEF8 differentially expressed in FDCP 8 homolog (mouse)
ECI1 enoyl-CoA delta isomerase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERN2 endoplasmic reticulum to nucleus signaling 2
FES FES proto-oncogene, tyrosine kinase
FHIT fragile histidine triad
FOSL1 FOS-like antigen 1
GALK1 galactokinase 1
GCH1 GTP cyclohydrolase 1
GNL1 guanine nucleotide binding protein-like 1
HIST1H2BH histone cluster 1, H2bh
HP haptoglobin
HSPA4L heat shock 70kDa protein 4-like
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRF9 interferon regulatory factor 9
KIAA0556 KIAA0556
KIAA0753 KIAA0753
KIF20A kinesin family member 20A
KLHL12 kelch-like family member 12
KLHL26 kelch-like family member 26
LIG4 ligase IV, DNA, ATP-dependent
LINC00115 long intergenic non-protein coding RNA 115
LRP5L low density lipoprotein receptor-related protein 5-like
LSP1 lymphocyte-specific protein 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LYPLA2P1 lysophospholipase II pseudogene 1
MCOLN1 mucolipin 1
MYBBP1A MYB binding protein (P160) 1a
NAT6 N-acetyltransferase 6 (GCN5-related)
NDE1 nudE neurodevelopment protein 1
NMB neuromedin B
NT5M 5',3'-nucleotidase, mitochondrial
NUBPL nucleotide binding protein-like
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
PDLIM2 PDZ and LIM domain 2 (mystique)
PFKL phosphofructokinase, liver
PGPEP1 pyroglutamyl-peptidase I
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLA2G12A phospholipase A2, group XIIA
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLH polymerase (DNA directed), eta
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PRSS53 protease, serine, 53
PYGB phosphorylase, glycogen; brain
QPRT quinolinate phosphoribosyltransferase
R3HCC1L R3H domain and coiled-coil containing 1-like
RHOBTB1 Rho-related BTB domain containing 1
RNF122 ring finger protein 122
RNF141 ring finger protein 141
RNF167 ring finger protein 167
RPL23AP32 ribosomal protein L23a pseudogene 32
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCAI suppressor of cancer cell invasion
SIRT2 sirtuin 2
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SMYD5 SMYD family member 5
SREK1IP1 SREK1-interacting protein 1
TBL3 transducin (beta)-like 3
TCTN2 tectonic family member 2
TMEM39B transmembrane protein 39B
TMOD3 tropomodulin 3 (ubiquitous)
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRPS1 trichorhinophalangeal syndrome I
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UNC119 unc-119 homolog (C. elegans)
XYLT2 xylosyltransferase II
ZC3H3 zinc finger CCCH-type containing 3
ZNF134 zinc finger protein 134
ZNF215 zinc finger protein 215
ZNF226 zinc finger protein 226
ZNF37BP zinc finger protein 37B, pseudogene
ZNF665 zinc finger protein 665
ZNF816 zinc finger protein 816
ZNF862 zinc finger protein 862