clozapine-416 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the clozapine-416 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ANKRD12 ankyrin repeat domain 12
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARSF arylsulfatase F
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASIC3 acid sensing (proton gated) ion channel 3
AVPR1B arginine vasopressin receptor 1B
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
C19ORF66 chromosome 19 open reading frame 66
C20ORF27 chromosome 20 open reading frame 27
CANX calnexin
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHAF1A chromatin assembly factor 1, subunit A (p150)
CLCN7 chloride channel, voltage-sensitive 7
CNTD2 cyclin N-terminal domain containing 2
CORO1B coronin, actin binding protein, 1B
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DLEC1 deleted in lung and esophageal cancer 1
DUS2 dihydrouridine synthase 2
ENG endoglin
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EPOR erythropoietin receptor
FAM153A family with sequence similarity 153, member A
FGF18 fibroblast growth factor 18
FN1 fibronectin 1
FOLR2 folate receptor 2 (fetal)
GAN gigaxonin
GDF11 growth differentiation factor 11
GINS3 GINS complex subunit 3 (Psf3 homolog)
GLS glutaminase
GRIP2 glutamate receptor interacting protein 2
HOXB7 homeobox B7
HPS1 Hermansky-Pudlak syndrome 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IRX4 iroquois homeobox 4
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KLHL3 kelch-like family member 3
LENEP lens epithelial protein
LIAS lipoic acid synthetase
LZTS1 leucine zipper, putative tumor suppressor 1
MPPE1 metallophosphoesterase 1
NADK NAD kinase
NDN necdin, melanoma antigen (MAGE) family member
NF2 neurofibromin 2 (merlin)
NID2 nidogen 2 (osteonidogen)
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NNAT neuronatin
NRGN neurogranin (protein kinase C substrate, RC3)
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PCDH7 protocadherin 7
PDCD2 programmed cell death 2
PDLIM7 PDZ and LIM domain 7 (enigma)
PHEX phosphate regulating endopeptidase homolog, X-linked
PHF20 PHD finger protein 20
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEC plectin
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
POFUT2 protein O-fucosyltransferase 2
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RAB8B RAB8B, member RAS oncogene family
RECQL5 RecQ protein-like 5
RHO rhodopsin
RRAS related RAS viral (r-ras) oncogene homolog
RRBP1 ribosome binding protein 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNDC3A RUN domain containing 3A
SAP18 Sin3A-associated protein, 18kDa
SEZ6L seizure related 6 homolog (mouse)-like
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SNX6 sorting nexin 6
SOD2 superoxide dismutase 2, mitochondrial
SOS2 son of sevenless homolog 2 (Drosophila)
SOX21 SRY (sex determining region Y)-box 21
SUGP2 SURP and G patch domain containing 2
SURF2 surfeit 2
TCEAL1 transcription elongation factor A (SII)-like 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMPRSS2 transmembrane protease, serine 2
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TP53TG1 TP53 target 1 (non-protein coding)
TRAC T cell receptor alpha constant
TYMP thymidine phosphorylase
UBE2I ubiquitin-conjugating enzyme E2I
UBE3A ubiquitin protein ligase E3A
VIM vimentin
VRK3 vaccinia related kinase 3
WIZ widely interspaced zinc finger motifs
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF408 zinc finger protein 408

decreased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
AAAS achalasia, adrenocortical insufficiency, alacrimia
AMDHD2 amidohydrolase domain containing 2
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
APOC4 apolipoprotein C-IV
ATP7B ATPase, Cu++ transporting, beta polypeptide
CAMKV CaM kinase-like vesicle-associated
CCL16 chemokine (C-C motif) ligand 16
CD300C CD300c molecule
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPO centromere protein O
CFAP70 cilia and flagella associated protein 70
CHKB choline kinase beta
CLDN14 claudin 14
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CPTP ceramide-1-phosphate transfer protein
CRMP1 collapsin response mediator protein 1
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CTAGE9 CTAGE family, member 9
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DGKD diacylglycerol kinase, delta 130kDa
DSCAM Down syndrome cell adhesion molecule
DYSF dysferlin
ECE2 endothelin converting enzyme 2
EPM2AIP1 EPM2A (laforin) interacting protein 1
FAM46C family with sequence similarity 46, member C
FGF16 fibroblast growth factor 16
FSCN3 fascin actin-bundling protein 3, testicular
FTCD formimidoyltransferase cyclodeaminase
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLB1L galactosidase, beta 1-like
GLRA2 glycine receptor, alpha 2
GPALPP1 GPALPP motifs containing 1
GREB1L growth regulation by estrogen in breast cancer-like
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HAND1 heart and neural crest derivatives expressed 1
HIST1H2AI histone cluster 1, H2ai
HOXB1 homeobox B1
HPSE heparanase
IFI30 interferon, gamma-inducible protein 30
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL15RA interleukin 15 receptor, alpha
IRS4 insulin receptor substrate 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LGMN legumain
LRRC20 leucine rich repeat containing 20
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYRM2 LYR motif containing 2
MAD2L1BP MAD2L1 binding protein
MAGEB2 melanoma antigen family B2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MEFV Mediterranean fever
MNT MAX network transcriptional repressor
N4BP3 NEDD4 binding protein 3
NIP7 NIP7, nucleolar pre-rRNA processing protein
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
OR2H1 olfactory receptor, family 2, subfamily H, member 1
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
OR7A17 olfactory receptor, family 7, subfamily A, member 17
PDZD7 PDZ domain containing 7
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PQLC1 PQ loop repeat containing 1
RAI14 retinoic acid induced 14
SCIN scinderin
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SGK2 serum/glucocorticoid regulated kinase 2
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOD3 superoxide dismutase 3, extracellular
SPINK5 serine peptidase inhibitor, Kazal type 5
SREK1IP1 SREK1-interacting protein 1
SYNDIG1 synapse differentiation inducing 1
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TLR5 toll-like receptor 5
TMEM168 transmembrane protein 168
TMEM19 transmembrane protein 19
TMEM8B transmembrane protein 8B
TRAF5 TNF receptor-associated factor 5
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
WDR76 WD repeat domain 76
WNT1 wingless-type MMTV integration site family, member 1
WT1-AS WT1 antisense RNA
ZNF189 zinc finger protein 189
ZNF195 zinc finger protein 195
ZNF33B zinc finger protein 33B
ZNF35 zinc finger protein 35
ZNF432 zinc finger protein 432
ZSCAN9 zinc finger and SCAN domain containing 9