clozapine-5589 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the clozapine-5589 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADAM22 ADAM metallopeptidase domain 22
AGMAT agmatine ureohydrolase (agmatinase)
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD26 ankyrin repeat domain 26
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
ARHGAP28 Rho GTPase activating protein 28
ARID4B AT rich interactive domain 4B (RBP1-like)
ART1 ADP-ribosyltransferase 1
ASIC4 acid sensing (proton gated) ion channel family member 4
ATAT1 alpha tubulin acetyltransferase 1
ATP10B ATPase, class V, type 10B
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BMP8B bone morphogenetic protein 8b
CA1 carbonic anhydrase I
CCDC6 coiled-coil domain containing 6
CCNG2 cyclin G2
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD47 CD47 molecule
CEP295 centrosomal protein 295kDa
CLEC4E C-type lectin domain family 4, member E
CLGN calmegin
CLTC clathrin, heavy chain (Hc)
COL4A2 collagen, type IV, alpha 2
CPEB3 cytoplasmic polyadenylation element binding protein 3
CYLD cylindromatosis (turban tumor syndrome)
DBR1 debranching RNA lariats 1
DMXL2 Dmx-like 2
DNAH7 dynein, axonemal, heavy chain 7
FBXL18 F-box and leucine-rich repeat protein 18
FBXO2 F-box protein 2
FGFR1OP FGFR1 oncogene partner
FH fumarate hydratase
FSTL1 follistatin-like 1
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNAS GNAS complex locus
GREB1 growth regulation by estrogen in breast cancer 1
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HDAC7 histone deacetylase 7
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HUS1 HUS1 checkpoint homolog (S. pombe)
ING4 inhibitor of growth family, member 4
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KANK1 KN motif and ankyrin repeat domains 1
KCTD17 potassium channel tetramerization domain containing 17
KIF25-AS1 KIF25 antisense RNA 1
KLHL22 kelch-like family member 22
LAMA4 laminin, alpha 4
LRP12 low density lipoprotein receptor-related protein 12
MAPK10 mitogen-activated protein kinase 10
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFSD7 major facilitator superfamily domain containing 7
MORN1 MORN repeat containing 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTSS1L metastasis suppressor 1-like
MYBPC3 myosin binding protein C, cardiac
NOVA2 neuro-oncological ventral antigen 2
NTM neurotrimin
OR52A1 olfactory receptor, family 52, subfamily A, member 1
PGK1 phosphoglycerate kinase 1
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PMEL premelanosome protein
POU2F2 POU class 2 homeobox 2
PRAMEF11 PRAME family member 11
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PVR poliovirus receptor
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RNF19B ring finger protein 19B
RORC RAR-related orphan receptor C
SAYSD1 SAYSVFN motif domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCLY selenocysteine lyase
SH3GL3 SH3-domain GRB2-like 3
SIRT5 sirtuin 5
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SPG20 spastic paraplegia 20 (Troyer syndrome)
SRSF7 serine/arginine-rich splicing factor 7
TBX3 T-box 3
TBXA2R thromboxane A2 receptor
THRB thyroid hormone receptor, beta
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM38B transmembrane protein 38B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRBC1 T cell receptor beta constant 1
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TUBGCP2 tubulin, gamma complex associated protein 2
UBE2B ubiquitin-conjugating enzyme E2B
UBOX5 U-box domain containing 5
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
YY2 YY2 transcription factor
ZDHHC17 zinc finger, DHHC-type containing 17
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABLIM3 actin binding LIM protein family, member 3
ACSF2 acyl-CoA synthetase family member 2
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AHNAK2 AHNAK nucleoprotein 2
ARMCX4 armadillo repeat containing, X-linked 4
ARPIN actin-related protein 2/3 complex inhibitor
ASPN asporin
ATP10D ATPase, class V, type 10D
BGLAP bone gamma-carboxyglutamate (gla) protein
C16ORF45 chromosome 16 open reading frame 45
C22ORF46 chromosome 22 open reading frame 46
C2ORF54 chromosome 2 open reading frame 54
CA5BP1 carbonic anhydrase VB pseudogene 1
CCP110 centriolar coiled coil protein 110kDa
CD1A CD1a molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD79B CD79b molecule, immunoglobulin-associated beta
CFAP69 cilia and flagella associated protein 69
DLK2 delta-like 2 homolog (Drosophila)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DUSP13 dual specificity phosphatase 13
EFNA3 ephrin-A3
FAM110B family with sequence similarity 110, member B
FAM120C family with sequence similarity 120C
FANCE Fanconi anemia, complementation group E
FBXO31 F-box protein 31
FGF6 fibroblast growth factor 6
FRMD1 FERM domain containing 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLB1L galactosidase, beta 1-like
GLI3 GLI family zinc finger 3
GNL1 guanine nucleotide binding protein-like 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRPR gastrin-releasing peptide receptor
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXD11 homeobox D11
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IL2 interleukin 2
IPO13 importin 13
IQCC IQ motif containing C
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM5C lysine (K)-specific demethylase 5C
KIAA0319L KIAA0319-like
LIME1 Lck interacting transmembrane adaptor 1
MALL mal, T-cell differentiation protein-like
MMP2 matrix metallopeptidase 2
MYO1F myosin IF
NACA2 nascent polypeptide-associated complex alpha subunit 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NTF3 neurotrophin 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PDE8B phosphodiesterase 8B
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLSCR4 phospholipid scramblase 4
POLM polymerase (DNA directed), mu
PRF1 perforin 1 (pore forming protein)
QPCT glutaminyl-peptide cyclotransferase
RAD54L2 RAD54-like 2 (S. cerevisiae)
RFPL3 ret finger protein-like 3
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIN1 Ras and Rab interactor 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL10L ribosomal protein L10-like
SCN1B sodium channel, voltage gated, type I beta subunit
SGCE sarcoglycan, epsilon
SHARPIN SHANK-associated RH domain interactor
SIPA1 signal-induced proliferation-associated 1
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLIT2 slit homolog 2 (Drosophila)
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNTA1 syntrophin, alpha 1
SSTR4 somatostatin receptor 4
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TMEM212 transmembrane protein 212
TMEM39B transmembrane protein 39B
TRPM4 transient receptor potential cation channel, subfamily M, member 4
VEGFC vascular endothelial growth factor C
VIM vimentin
VPS9D1 VPS9 domain containing 1
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
WLS wntless Wnt ligand secretion mediator
ZFHX2 zinc finger homeobox 2
ZNF16 zinc finger protein 16
ZNF204P zinc finger protein 204, pseudogene
ZNF304 zinc finger protein 304
ZNF551 zinc finger protein 551
ZNF639 zinc finger protein 639