clozapine-5630 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the clozapine-5630 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AKAP6 A kinase (PRKA) anchor protein 6
ANO1 anoctamin 1, calcium activated chloride channel
APAF1 apoptotic peptidase activating factor 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATG10 autophagy related 10
ATXN2L ataxin 2-like
C2CD2L C2CD2-like
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CARTPT CART prepropeptide
CD53 CD53 molecule
CD6 CD6 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK18 cyclin-dependent kinase 18
CEP295 centrosomal protein 295kDa
CFAP69 cilia and flagella associated protein 69
CIB2 calcium and integrin binding family member 2
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CLSTN3 calsyntenin 3
CNN1 calponin 1, basic, smooth muscle
COL17A1 collagen, type XVII, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CSNK1G1 casein kinase 1, gamma 1
CTIF CBP80/20-dependent translation initiation factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH4 cytohesin 4
DCTN1 dynactin 1
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DPF1 D4, zinc and double PHD fingers family 1
DPY19L1 dpy-19-like 1 (C. elegans)
DUX1 double homeobox 1
EDNRA endothelin receptor type A
EGFL7 EGF-like-domain, multiple 7
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELL elongation factor RNA polymerase II
FGFBP1 fibroblast growth factor binding protein 1
FPR1 formyl peptide receptor 1
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GLYAT glycine-N-acyltransferase
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPSM3 G-protein signaling modulator 3
HFE hemochromatosis
HOXB5 homeobox B5
HR hair growth associated
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIF5A kinesin family member 5A
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT17 keratin 17, type I
LAMP1 lysosomal-associated membrane protein 1
LHX2 LIM homeobox 2
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LOC440895 two pore channel 3 pseudogene
LOC51145 uncharacterized LOC51145
MC5R melanocortin 5 receptor
MMP25 matrix metallopeptidase 25
MOB3B MOB kinase activator 3B
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MX2 MX dynamin-like GTPase 2
MYH14 myosin, heavy chain 14, non-muscle
NOVA2 neuro-oncological ventral antigen 2
PAX2 paired box 2
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PKD2L2 polycystic kidney disease 2-like 2
PLK3 polo-like kinase 3
PON1 paraoxonase 1
PON3 paraoxonase 3
POU6F1 POU class 6 homeobox 1
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PSORS1C1 psoriasis susceptibility 1 candidate 1
RAP2A RAP2A, member of RAS oncogene family
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAC SH3 and cysteine rich domain
STXBP5L syntaxin binding protein 5-like
TBC1D22B TBC1 domain family, member 22B
TPMT thiopurine S-methyltransferase
TRIL TLR4 interactor with leucine-rich repeats
TRPM2 transient receptor potential cation channel, subfamily M, member 2
ULBP1 UL16 binding protein 1
USP2 ubiquitin specific peptidase 2
VAV2 vav 2 guanine nucleotide exchange factor
VCL vinculin
ZBED4 zinc finger, BED-type containing 4
ZNF467 zinc finger protein 467
ZNF695 zinc finger protein 695
ZNF76 zinc finger protein 76
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADTRP androgen-dependent TFPI-regulating protein
ALS2CL ALS2 C-terminal like
APOLD1 apolipoprotein L domain containing 1
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARPIN actin-related protein 2/3 complex inhibitor
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAT1 alpha tubulin acetyltransferase 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAHCC1 BAH domain and coiled-coil containing 1
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF79 chromosome 14 open reading frame 79
C2ORF54 chromosome 2 open reading frame 54
C7ORF43 chromosome 7 open reading frame 43
CCDC134 coiled-coil domain containing 134
CCDC9 coiled-coil domain containing 9
CCNO cyclin O
CHML choroideremia-like (Rab escort protein 2)
CHST10 carbohydrate sulfotransferase 10
CRIP1 cysteine-rich protein 1 (intestinal)
CRLF1 cytokine receptor-like factor 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTSK cathepsin K
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DMTN dematin actin binding protein
DRD1 dopamine receptor D1
DUSP8 dual specificity phosphatase 8
EFHD2 EF-hand domain family, member D2
EVPL envoplakin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM155B family with sequence similarity 155, member B
FAM204A family with sequence similarity 204, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FRK fyn-related Src family tyrosine kinase
FYCO1 FYVE and coiled-coil domain containing 1
GFI1 growth factor independent 1 transcription repressor
GMPR guanosine monophosphate reductase
GPR27 G protein-coupled receptor 27
GUSBP3 glucuronidase, beta pseudogene 3
HDAC11 histone deacetylase 11
HOXB2 homeobox B2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INPP1 inositol polyphosphate-1-phosphatase
KIAA0319L KIAA0319-like
KIAA0556 KIAA0556
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC390998 ribosomal protein L10 pseudogene
LRRC61 leucine rich repeat containing 61
MALL mal, T-cell differentiation protein-like
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NBEAL2 neurobeachin-like 2
NRSN2 neurensin 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PARP16 poly (ADP-ribose) polymerase family, member 16
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE8B phosphodiesterase 8B
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PRR14L proline rich 14-like
PXN paxillin
RGS2 regulator of G-protein signaling 2
RHOBTB2 Rho-related BTB domain containing 2
RNF39 ring finger protein 39
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
RUNDC3B RUN domain containing 3B
S100A6 S100 calcium binding protein A6
S100A9 S100 calcium binding protein A9
SAYSD1 SAYSVFN motif domain containing 1
SCN1B sodium channel, voltage gated, type I beta subunit
SDC3 syndecan 3
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SSBP3 single stranded DNA binding protein 3
ST5 suppression of tumorigenicity 5
TRDMT1 tRNA aspartic acid methyltransferase 1
TUBA3C tubulin, alpha 3c
UBTD1 ubiquitin domain containing 1
VAX2 ventral anterior homeobox 2
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZBTB48 zinc finger and BTB domain containing 48
ZMAT5 zinc finger, matrin-type 5
ZNF34 zinc finger protein 34
ZNF573 zinc finger protein 573
ZNF701 zinc finger protein 701
ZNF8 zinc finger protein 8