clozapine Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia. (Chemical Entities of Biological Interest Ontology, CHEBI_3766)
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Genes

28 genes co-occuring with the biological term clozapine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DRD4 dopamine receptor D4
GFRA1 GDNF family receptor alpha 1
GFRA2 GDNF family receptor alpha 2
GFRA3 GDNF family receptor alpha 3
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSK3B glycogen synthase kinase 3 beta
HRH1 histamine receptor H1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
IFNG interferon, gamma
LEP leptin
LEPR leptin receptor
MC4R melanocortin 4 receptor
NRG1 neuregulin 1
NRXN1 neurexin 1
PRL prolactin
PRLR prolactin receptor
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
TNF tumor necrosis factor