cml Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS. (Experimental Factor Ontology, EFO_0000339)
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Genes

193 genes co-occuring with the biological term cml in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ADAR adenosine deaminase, RNA-specific
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHI1 Abelson helper integration site 1
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AR androgen receptor
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BATF2 basic leucine zipper transcription factor, ATF-like 2
BAX BCL2-associated X protein
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCR breakpoint cluster region
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL19 chemokine (C-C motif) ligand 19
CCR7 chemokine (C-C motif) receptor 7
CD247 CD247 molecule
CD34 CD34 molecule
CD38 CD38 molecule
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDH13 cadherin 13
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP12 dual specificity phosphatase 12
EIF4E eukaryotic translation initiation factor 4E
ERCC1 excision repair cross-complementation group 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2R coagulation factor II (thrombin) receptor
FBXO5 F-box protein 5
FGFR3 fibroblast growth factor receptor 3
FIP1L1 factor interacting with PAPOLA and CPSF1
FLT3 fms-related tyrosine kinase 3
FOXM1 forkhead box M1
FOXO3 forkhead box O3
GAB2 GRB2-associated binding protein 2
GATA2 GATA binding protein 2
GFI1 growth factor independent 1 transcription repressor
GPX1 glutathione peroxidase 1
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HDC histidine decarboxylase
HES1 hes family bHLH transcription factor 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HOXA11 homeobox A11
HOXA4 homeobox A4
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFNG interferon, gamma
IL10 interleukin 10
IL1RAP interleukin 1 receptor accessory protein
IL1RN interleukin 1 receptor antagonist
IL33 interleukin 33
IL6 interleukin 6
IRF8 interferon regulatory factor 8
JAK2 Janus kinase 2
JUNB jun B proto-oncogene
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KRAS Kirsten rat sarcoma viral oncogene homolog
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LIG3 ligase III, DNA, ATP-dependent
LMO2 LIM domain only 2 (rhombotin-like 1)
LTC4S leukotriene C4 synthase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MCL1 myeloid cell leukemia 1
MCPH1 microcephalin 1
MECOM MDS1 and EVI1 complex locus
MIR155 microRNA 155
MIR199B microRNA 199b
MIR21 microRNA 21
MIR219A2 microRNA 219a-2
MIR22 microRNA 22
MIR31 microRNA 31
MIR564 microRNA 564
MIR633 microRNA 633
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME2 NME/NM23 nucleoside diphosphate kinase 2
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NOV nephroblastoma overexpressed
OAZ1 ornithine decarboxylase antizyme 1
ODF4 outer dense fiber of sperm tails 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PHF6 PHD finger protein 6
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PLK1 polo-like kinase 1
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PRAME preferentially expressed antigen in melanoma
PRDM2 PR domain containing 2, with ZNF domain
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PTEN phosphatase and tensin homolog
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB38 RAB38, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RASEF RAS and EF-hand domain containing
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM15 RNA binding motif protein 15
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RUNX1 runt-related transcription factor 1
SALL4 spalt-like transcription factor 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN3 sestrin 3
SET SET nuclear proto-oncogene
SF3B1 splicing factor 3b, subunit 1, 155kDa
SHH sonic hedgehog
SIRT1 sirtuin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SOCS3 suppressor of cytokine signaling 3
SPAG9 sperm associated antigen 9
SPHK1 sphingosine kinase 1
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
ST2 suppression of tumorigenicity 2
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SYK spleen tyrosine kinase
TBCE tubulin folding cofactor E
TEX101 testis expressed 101
TGFB1 transforming growth factor, beta 1
THAP11 THAP domain containing 11
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TKTL1 transketolase-like 1
TNF tumor necrosis factor
TP53 tumor protein p53
UGCG UDP-glucose ceramide glucosyltransferase
WNT1 wingless-type MMTV integration site family, member 1
WRN Werner syndrome, RecQ helicase-like
WT1 Wilms tumor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)