coeliac disease Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.|A malabsorption syndrome that is precipitated by the ingestion of GLUTEN-containing foods, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.|A food hypersensitivity that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.|A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION. (Experimental Factor Ontology, EFO_0001060)
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Genes

15 genes associated with the disease coeliac disease in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
CCR1 chemokine (C-C motif) receptor 1
CCR3 chemokine (C-C motif) receptor 3
CTLA4 cytotoxic T-lymphocyte-associated protein 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFNG interferon, gamma
IL12A interleukin 12A
IL18RAP interleukin 18 receptor accessory protein
IL2 interleukin 2
IL21 interleukin 21
LPP LIM domain containing preferred translocation partner in lipoma
RGS1 regulator of G-protein signaling 1
SH2B3 SH2B adaptor protein 3
TAGAP T-cell activation RhoGTPase activating protein