cohesin complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). (Gene Ontology, GO_0008278)
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11 proteins localized to the cohesin complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SMC3 structural maintenance of chromosomes 3 0.663342
STAG3 stromal antigen 3 0.663342
SGOL2 shugoshin-like 2 (S. pombe) 0.663342
SGOL1 shugoshin-like 1 (S. pombe) 0.663342
SMC1B structural maintenance of chromosomes 1B 0.663342
SMC1A structural maintenance of chromosomes 1A 0.663342
WAPAL wings apart-like homolog (Drosophila) 0.663342
RAD21 RAD21 homolog (S. pombe) 0.237908
RAD21L1 RAD21-like 1 (S. pombe) 0.237908
REC8 REC8 meiotic recombination protein 0.03318
CDCA5 cell division cycle associated 5 0.03318