cohesin complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). (Gene Ontology, GO_0008278)
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114 proteins co-occuring with the cohesin complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SMC3 structural maintenance of chromosomes 3 2.90572
RAD21 RAD21 homolog (S. pombe) 2.82084
NIPBL Nipped-B homolog (Drosophila) 2.44098
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 2.27053
SMC1A structural maintenance of chromosomes 1A 2.1559
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2.11585
STAG2 stromal antigen 2 2.06559
STAG3 stromal antigen 3 1.88901
SMC1B structural maintenance of chromosomes 1B 1.66296
SGOL1 shugoshin-like 1 (S. pombe) 1.6342
CTCF CCCTC-binding factor (zinc finger protein) 1.53161
WAPAL wings apart-like homolog (Drosophila) 1.43726
CDCA5 cell division cycle associated 5 1.36197
REC8 REC8 meiotic recombination protein 1.2825
HDAC8 histone deacetylase 8 1.27505
SMC5 structural maintenance of chromosomes 5 1.16184
STAG1 stromal antigen 1 1.15825
SYCP3 synaptonemal complex protein 3 1.07207
PTTG1 pituitary tumor-transforming 1 1.02829
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 0.984393
DDX11L8 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 like 8 0.938795
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 0.922322
PDS5B PDS5 cohesin associated factor B 0.890245
PLK1 polo-like kinase 1 0.851124
WFDC5 WAP four-disulfide core domain 5 0.807982
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.79148
MAU2 MAU2 sister chromatid cohesion factor 0.791022
SYCP1 synaptonemal complex protein 1 0.786902
AURKB aurora kinase B 0.777298
SPO11 SPO11 meiotic protein covalently bound to DSB 0.772275
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 0.771363
TET2 tet methylcytosine dioxygenase 2 0.747737
DSCC1 DNA replication and sister chromatid cohesion 1 0.744122
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 0.742318
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 0.739614
DDX12P DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene 0.709693
NCAPH2 non-SMC condensin II complex, subunit H2 0.688576
SYCP2 synaptonemal complex protein 2 0.652159
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 0.646145
SMC2 structural maintenance of chromosomes 2 0.627335
ATM ATM serine/threonine kinase 0.618406
CARS cysteinyl-tRNA synthetase 0.611201
MAN2C1 mannosidase, alpha, class 2C, member 1 0.606128
BAALC brain and acute leukemia, cytoplasmic 0.596855
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.590133
PDS5A PDS5 cohesin associated factor A 0.562187
CDC14A cell division cycle 14A 0.529208
INCENP inner centromere protein antigens 135/155kDa 0.494585
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.465598
MSH4 mutS homolog 4 0.458006
CDC20 cell division cycle 20 0.437356
GMNN geminin, DNA replication inhibitor 0.422782
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 0.416902
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.416511
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.410259
PCDH11Y protocadherin 11 Y-linked 0.407919
PHF21A PHD finger protein 21A 0.405971
PRDM9 PR domain containing 9 0.400916
PCDH11X protocadherin 11 X-linked 0.400139
CDK1 cyclin-dependent kinase 1 0.383124
WDR61 WD repeat domain 61 0.376202
HORMAD1 HORMA domain containing 1 0.374666
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.369301
MAD2L1P1 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene 1 0.366623
ASXL1 additional sex combs like transcriptional regulator 1 0.362804
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.362422
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.358609
ERCC6L excision repair cross-complementation group 6-like 0.354422
CCNB1 cyclin B1 0.351002
ANAPC4 anaphase promoting complex subunit 4 0.341907
IGF2 insulin-like growth factor 2 0.340773
SMC4 structural maintenance of chromosomes 4 0.337373
SGOL2 shugoshin-like 2 (S. pombe) 0.326078
DIO3 deiodinase, iodothyronine, type III 0.320451
EME1 essential meiotic structure-specific endonuclease 1 0.302168
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.276671
TRIM27 tripartite motif containing 27 0.274835
RAD50 RAD50 homolog (S. cerevisiae) 0.273734
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.271167
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.262025
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 0.262025
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.260566
H3F3B H3 histone, family 3B (H3.3B) 0.258745
ATR ATR serine/threonine kinase 0.258745
H3F3A H3 histone, family 3A 0.258745
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.253291
IFNG interferon, gamma 0.251114
NEK1 NIMA-related kinase 1 0.245685
MAP3K12 mitogen-activated protein kinase kinase kinase 12 0.235966
SMC6 structural maintenance of chromosomes 6 0.235966
PIAS2 protein inhibitor of activated STAT, 2 0.232386
KDM1A lysine (K)-specific demethylase 1A 0.231672
FEN1 flap structure-specific endonuclease 1 0.225267
MRC1 mannose receptor, C type 1 0.222083
DNAH8 dynein, axonemal, heavy chain 8 0.22173
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.210894
H2AFX H2A histone family, member X 0.209858
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.207794
STRA8 stimulated by retinoic acid 8 0.207451
KNTC1 kinetochore associated 1 0.19601
UBE2K ubiquitin-conjugating enzyme E2K 0.189222
LGALS4 lectin, galactoside-binding, soluble, 4 0.188905
TPI1 triosephosphate isomerase 1 0.188905
ITM2B integral membrane protein 2B 0.182122
CENPE centromere protein E, 312kDa 0.181227
DCXR dicarbonyl/L-xylulose reductase 0.179167
CAND1 cullin-associated and neddylation-dissociated 1 0.176024
CDC5L cell division cycle 5-like 0.173273
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 0.173003
UBE2S ubiquitin-conjugating enzyme E2S 0.172201
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.162763
XPO1 exportin 1 0.138845
BRD4 bromodomain containing 4 0.133587
NUMA1 nuclear mitotic apparatus protein 1 0.127497