The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. (Gene Ontology, GO_0002065)
11 genes participating in the columnar/cuboidal epithelial cell differentiation biological process from the curated GO Biological Process Annotations 2023 dataset.